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    Apparatus and method for separating foreground from background
    1.
    发明授权
    Apparatus and method for separating foreground from background 有权
    用于从背景分离前景的装置和方法

    公开(公告)号：US09165192B2

    公开(公告)日：2015-10-20

    申请号：US13206147

    申请日：2011-08-09

    申请人： Young-gwan Jo

    发明人： Young-gwan Jo

    IPC分类号： H04N7/18 ,  G06K9/48 ,  G06K9/00 ,  G06T7/00

    CPC分类号： G06K9/00771 ,  G06T7/12 ,  G06T7/194 ,  G06T2207/30232

    摘要： Provided are apparatuses and methods for separating an image into a foreground and a background. The apparatus includes: an edge image generating unit which generates an edge image for an original image, wherein the original image includes the background and the foreground; a background edge model renewing unit which renews a background edge model based on the generated edge image; and a foreground edge extracting unit which generates a foreground edge image based on the generated edge image and the renewed background edge model.

    摘要翻译： 提供了将图像分离成前景和背景的装置和方法。 该装置包括：边缘图像生成单元，其生成原始图像的边缘图像，其中原始图像包括背景和前景; 背景边缘模型更新单元，其基于生成的边缘图像来更新背景边缘模型; 以及前景边缘提取单元，其基于所生成的边缘图像和更新的背景边缘模型生成前景边缘图像。

    Controlled release complex composition comprising angiotensin-II-receptor blockers and HMG-CoA reductase inhibitors
    3.
    发明授权
    Controlled release complex composition comprising angiotensin-II-receptor blockers and HMG-CoA reductase inhibitors 有权
    包含血管紧张素-II受体阻断剂和HMG-CoA还原酶抑制剂的控制释放复合物组合物

    公开(公告)号：US08642083B2

    公开(公告)日：2014-02-04

    申请号：US12513054

    申请日：2007-10-30

    申请人： Sung Wuk Kim ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja Seong Koo ,  Jae Woon Son

    发明人： Sung Wuk Kim ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja Seong Koo ,  Jae Woon Son

    IPC分类号： A61K9/42 ,  A61K9/40 ,  A61K9/36 ,  A61K9/28 ,  A61K9/20

    CPC分类号： A61K31/00 ,  A61K9/2077 ,  A61K9/209

    摘要： Disclosed herein is a lag time delayed-release combination pharmaceutical composition comprising of an angiotensin-II-receptor blocker and an HMG-CoA reductase inhibitor, as well as a preparation method thereof. The composition is designed based on chronotherapy in which active ingredients are administered to have different onset times, such that the release of each active ingredient of the composition in body can be lag time delayed to a specific rate. Also, the composition is very effective for the treatment of hypertension and the prevention of complications in patients having metabolic syndromes which show diabetes, obesity, hyperlipidemia, coronary artery diseases and the like. More specifically, the composition is a drug delivery system designed such that the release of each drug is controlled to a specific rate, and it can show the most ideal effect, when it is absorbed in body.

    摘要翻译： 本文公开了包含血管紧张素-II-受体阻断剂和HMG-CoA还原酶抑制剂的滞后时间延迟释放组合药物组合物及其制备方法。 该组合物是基于治疗时间来设计的，其中施用活性成分具有不同的起始时间，使得组合物的每种活性成分在体内的释放可延迟到特定的速率。 此外，该组合物对于治疗高血压和预防具有显示糖尿病，肥胖症，高脂血症，冠状动脉疾病等的代谢综合征的患者的并发症非常有效。 更具体地，组合物是药物递送系统，其被设计成使得每种药物的释放被控制到特定的速率，并且当其被吸收在体内时它可以显示出最理想的效果。

    N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
    7.
    发明申请
    N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 有权
    N，N-二甲基咪唑二恶唑二羧酸二甲酯，其制备方法和包含其的药物组合物

    公开(公告)号：US20100249241A1

    公开(公告)日：2010-09-30

    申请号：US12733711

    申请日：2008-09-19

    申请人： Sung Wuk KIM ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja Seong Koo ,  Young Woong Kim ,  Byoung Ha Kim ,  Duck Kim

    发明人： Sung Wuk KIM ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja Seong Koo ,  Young Woong Kim ,  Byoung Ha Kim ,  Duck Kim

    IPC分类号： A61K31/155 ,  C07C279/26 ,  C07C277/00 ,  A61P35/00 ,  A61P3/10 ,  A61P21/00 ,  A61P29/00

    CPC分类号： C07C279/26 ,  C07C55/08 ,  C07C55/12 ,  C07C55/14 ,  C07C59/245

    摘要： Disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.

    摘要翻译： 本文公开了N，N-二甲基亚氨基二亚甲基二酰胺的新型二羧酸盐及其制备方法和包含其的药物组合物。 更具体地，本文公开了N，N-二甲基亚氨基二甲酰亚胺二酰胺的新型二羧酸盐，通过使N，N-二甲基亚氨基二碳二亚胺二酰胺与特定二羧酸反应制备的结晶酸加成盐，其具有改善的物理和化学性质，包括溶解度 稳定性，非吸湿性和抗粘连性，低毒性，因此在预防和治疗不仅糖尿病及其所谓的代谢综合征患者的并发症方面非常有效，其中糖尿病，肥胖，高脂血症， 脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征等组合，还包括p53基因缺陷型癌症，肌肉酸痛，肌肉细胞毒性和横纹肌溶解症，以及其制备方法和包含其的药物组合物。

    COMBINED PREPARATION FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BASED ON CHRONOTHERAPY THEORY
    8.
    发明申请
    COMBINED PREPARATION FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BASED ON CHRONOTHERAPY THEORY 审中-公开
    基于循环理论治疗心血管疾病的联合制剂

    公开(公告)号：US20100047341A1

    公开(公告)日：2010-02-25

    申请号：US12445204

    申请日：2007-10-10

    申请人： Sung Wuk Kim ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja-Seong Koo ,  Sang Ouk Sun

    发明人： Sung Wuk Kim ,  Sung Soo Jun ,  Young Gwan Jo ,  Ja-Seong Koo ,  Sang Ouk Sun

    IPC分类号： A61K9/54 ,  A61K9/24 ,  A61K31/4178

    CPC分类号： A61K31/4184 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/2086 ,  A61K9/209 ,  A61K9/2853 ,  A61K9/2866 ,  A61K9/5084 ,  A61K31/4178 ,  A61K31/4422 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to a functional combination preparation comprising a dihydropyridine-based calcium channel blocker such as amlodipine and an ARB (Angiotensin-2 receptor blocker) such as losartan. In particular, the present invention relates to a chronotherapeutical combination pharmaceutical formulations with controlled-release for the prevention or treatment of cardiovascular disease, which is formulated in accordance with xenobiotics and chronotherapy for enabling the two drugs to be chronotherapeutically released, thereby improving the therapeutic activity as compared to the co-administration of each drug in the form of a single pill, while reducing side effects and maintaining the therapeutic activity as high as possible at the time of day when the risk of a complication of cardiovascular disease is highest.

    摘要翻译： 本发明涉及包含二氢吡啶类钙通道阻断剂如氨氯地平和ARB（血管紧张素-2受体阻断剂）如洛沙坦的功能性组合制剂。 特别地，本发明涉及具有控制释放以用于预防或治疗心血管疾病的时间疗法组合药物制剂，所述药物制剂根据异生素和时间疗法配制，以使两种药物能够进行治疗性释放，从而改善治疗活性 与单一药丸形式的每种药物的共同给药相比，同时在心血管疾病并发症的风险最高的一天中减少副作用并保持尽可能高的治疗活性。

    Apparatus and method for estimating the number of objects included in an image
    10.
    发明授权
    Apparatus and method for estimating the number of objects included in an image 有权
    用于估计包括在图像中的物体的数量的装置和方法

    公开(公告)号：US08798369B2

    公开(公告)日：2014-08-05

    申请号：US13458390

    申请日：2012-04-27

    申请人： Young-gwan Jo ,  Seung-in Noh ,  Yong-jin Park ,  Joon-hee Han

    发明人： Young-gwan Jo ,  Seung-in Noh ,  Yong-jin Park ,  Joon-hee Han

    IPC分类号： G06K9/46 ,  G06K9/66 ,  G06K9/62 ,  G06K9/34 ,  G06K9/00

    CPC分类号： G06T7/254 ,  G06T2207/10016 ,  G06T2207/10024 ,  G06T2207/20076 ,  G06T2207/30232 ,  G06T2207/30242

    摘要： An apparatus and method for estimating the number of objects in an input image are disclosed. The apparatus includes: a learning unit that calculates counted values of a linear regression function by learning an arbitrary image; a separation unit that separates a foreground region and a background region of the input image; an extraction unit that searches for features that require an amount of calculation that is below a particular threshold from features having high correlation with each other feature and extracts the features from the separated foreground region; and an estimation unit that estimates the number of objects in the foreground region as a dependent variable by allocating the counted values of the linear regression function that are calculated by the learning unit and the features that are extracted by the extraction unit as independent variables of a linear regression function.

    摘要翻译： 公开了一种用于估计输入图像中的对象数量的装置和方法。 该装置包括：学习单元，其通过学习任意图像来计算线性回归函数的计数值; 分离单元，其分离所述输入图像的前景区域和背景区域; 提取单元，其从相互之间具有高相关性的特征中搜索需要低于特定阈值的计算量的特征，并从分离的前景区域中提取特征; 以及估计单元，其通过将由学习单元计算的线性回归函数的计数值和由提取单元提取的特征分配为自变量来估计前景区域中的对象的数量作为因变量 线性回归函数。