摘要:
An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
摘要:
The present invention relates to a pharmaceutical composition for treating scars on the skin, comprising a mixture of botulinum toxin and air. The mixture of botulinum toxin and air according to the present invention, when injected in the dermis, may temporarily removed the elasticity of the dermis and flatten out the depressed part of the scar, and thus enables elaborate intradermic resection and increases the therapeutic effects of lasers for treating pulsed dye laser or of fractional lasers. Thus, scars on the skin can be effectively improved through a one-time operation without negatively affecting the daily lives of patients.
摘要:
A flexible solar light includes a lamp portion, a main body portion, and a goose neck portion. The goose neck portion connects the lamp portion and the main body portion, which is flexible and configured to be bent in a shape and maintains the bent shape. The lamp portion and the main body portion are configured to form a portable flashlight, a light stand, a wall lamp, or a ceiling lamp by engaging or separating each other.
摘要:
A method of fabricating a transparent electrode for use in a quantum dot sensitized solar cell, and a quantum dot sensitized solar cell fabricated according to the method are provided. According to the fabrication method, (S1) quantum dot precursor is introduced into a high pressure storage vessel and a quantum dot precursor is dissolved using subcritical fluid or supercritical fluid; (S2) the quantum dot precursor fluid prepared at (S1) is transported to contact with a conductive thin layer substrate comprised of a metal oxide placed in a high pressure reaction vessel, thereby causing the quantum dot precursor to be adsorbed in the metal oxide thin layer; (S3) non-adsorbed quantum dot precursor fluid of (S2) is transported and thus recovered to the high pressure storage vessel together with the subcritical fluid or supercritical fluid; and (S4) the subcritical fluid or supercritical fluid is removed from the high pressure reaction vessel, and the quantum dot precursor, adsorbed at (S2), is reacted with a second element which constitutes the quantum dot or a compound comprising the second element.
摘要:
The present invention relates to an electrically conductive metal composite embroidery yarn and embroidered circuit using thereof which may be applicable to smart textiles. More particularly, this invention relates to an electrically conductive metal composite embroidery yarn and embroidered circuit for smart textiles which can be used as power supply and signal transmission lines. The present invention provides an embroidered circuit which consists of a metal composite embroidery yarn and a dielectric fabric substrate, wherein the electrically conductive metal composite embroidery yarn is embroidered on the dielectric fabric substrate to form a circuit.
摘要:
Disclosed are novel triazole derivatives. Exhibiting excellent antifungal activity and in vivo safety, they are useful for the treatment or prevention of fungal infections caused by a wide spectrum of fungi.
摘要:
Disclosed herein are novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives represented by Formula 1, or pharmaceutically acceptable salts thereof. Also disclosed is a pharmaceutical composition for treating or preventing premature ejaculation including the compound. The 1,3-dihydro-5-isobenzofurancarbonitrile derivatives have a short half-life and inhibit the ejaculation process by selectively inhibiting serotonin reuptake via a serotonin reuptake transporter present in a presynaptic neuron. Thus, the compounds are useful in the treatment and prevention of premature ejaculation.
摘要:
The invention relates to a power supply for a liquid crystal display using a light emitting diode for a backlight unit, and more particularly, to a power supply combining a DC power supply outside the liquid crystal display with a driving power supply inside the liquid crystal display into a single power supply. The power supply for a liquid crystal display according to an aspect of the invention may include: a power conversion section converting commercial AC power into at least one operating power having a predetermined voltage level through a switching operation; a backlight driving section switching the operating power from the power conversion section into backlight driving power; and a power switching control section controlling the switching operation of the power conversion section on the basis of a first feedback signal having a voltage level of the operating power from the power conversion section and a second feedback signal having a voltage level of the backlight driving power from the backlight driving section, wherein the power conversion section, the backlight driving section and the power switching control section are mounted on a single printed circuit board.
摘要:
A printing system and a printing method providing a menu to change printing options to conserve developer. The printing method includes determining whether a developer is deficient by checking the status of the developer when a print command is input; setting new printing options upon determining the deficiency of the developer; and generating and printing an image according to the newly set printing options. Accordingly, it is possible to print more pages using the same amount of developer. Based on the menu to change the printing options, the user can select to change the resolution, the scale of the print, and the N-up, to conserve the developer.
摘要:
The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.