N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
    1.
    发明申请
    N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 有权
    N,N-二甲基咪唑二恶唑二羧酸二甲酯,其制备方法和包含其的药物组合物

    公开(公告)号:US20100249241A1

    公开(公告)日:2010-09-30

    申请号:US12733711

    申请日:2008-09-19

    摘要: Disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.

    摘要翻译: 本文公开了N,N-二甲基亚氨基二亚甲基二酰胺的新型二羧酸盐及其制备方法和包含其的药物组合物。 更具体地,本文公开了N,N-二甲基亚氨基二甲酰亚胺二酰胺的新型二羧酸盐,通过使N,N-二甲基亚氨基二碳二亚胺二酰胺与特定二羧酸反应制备的结晶酸加成盐,其具有改善的物理和化学性质,包括溶解度 稳定性,非吸湿性和抗粘连性,低毒性,因此在预防和治疗不仅糖尿病及其所谓的代谢综合征患者的并发症方面非常有效,其中糖尿病,肥胖,高脂血症, 脂肪肝,冠状动脉疾病,骨质疏松症,多囊卵巢综合征等组合,还包括p53基因缺陷型癌症,肌肉酸痛,肌肉细胞毒性和横纹肌溶解症,以及其制备方法和包含其的药物组合物。

    N,N-dimethyl imidodicarbonimidic diamide dicarboxylate, method for producing the same and pharmaceutical compositions comprising the same
    2.
    发明授权
    N,N-dimethyl imidodicarbonimidic diamide dicarboxylate, method for producing the same and pharmaceutical compositions comprising the same 有权
    N,N-二甲基亚氨基二酰亚胺二酰胺二羧酸酯,其制备方法和包含其的药物组合物

    公开(公告)号:US08076377B2

    公开(公告)日:2011-12-13

    申请号:US12733711

    申请日:2008-09-19

    摘要: Disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a crystalline acid addition salt prepared by allowing N,N-dimethylimidodicarbonimidic diamide to react with a specific dicarboxylic acid, which has improved physical and chemical properties including solubility, stability, non-hygroscopicity and anti-adhesive properties, and low toxicity, and thus is very effective in the prevention and treatment of not only diabetes and its complications in patients with so-called metabolic syndromes, in which diabetes, obesity, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndromes, etc. appear in combination, but also p53 gene-deficient cancers, muscular pain, muscle cytotoxicity and rhabdomyolysis, as well as a preparation method thereof and a pharmaceutical composition comprising the same.

    摘要翻译: 本文公开了N,N-二甲基亚氨基二亚甲基二酰胺的新型二羧酸盐及其制备方法和包含其的药物组合物。 更具体地,本文公开了N,N-二甲基亚氨基二甲酰亚胺二酰胺的新型二羧酸盐,通过使N,N-二甲基亚氨基二碳二亚胺二酰胺与特定二羧酸反应制备的结晶酸加成盐,其具有改善的物理和化学性质,包括溶解度 稳定性,非吸湿性和抗粘连性,低毒性,因此在预防和治疗不仅糖尿病及其所谓的代谢综合征患者的并发症方面非常有效,其中糖尿病,肥胖,高脂血症, 脂肪肝,冠状动脉疾病,骨质疏松症,多囊卵巢综合征等组合,还包括p53基因缺陷型癌症,肌肉酸痛,肌肉细胞毒性和横纹肌溶解症,以及其制备方法和包含其的药物组合物。

    N, N-dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same
    3.
    发明授权
    N, N-dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same 有权
    N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物

    公开(公告)号:US08058312B2

    公开(公告)日:2011-11-15

    申请号:US12524695

    申请日:2008-01-29

    CPC分类号: A61K31/155 C07C279/26

    摘要: The present invention relates to N,N-dimethyl imidodicarbonimidic diamide acetate, a method of preparing the same and a pharmaceutical composition comprising the same, and more particularly, to N,N-dimethyl imidodicarbonimidic diamide acetate which is a crystalline acid addition salt prepared by reacting N,N-dimethyl imidodicarbonimidic diamide with acetic acid, and which is very effective as a therapeutic agent for treating metabolic syndromes that glycosuria and diabetes mellitus, obesity, hyperlipidemia, fatty liver, coronary heart disease, osteoporosis, polycystic ovarian syndrome, a cancer depleted of gene P53, etc. are complexly occurred; treating diabetes mellitus and preventing its complication; and treating a cancer and preventing myalgia, muscle cell cytotoxicity and rhabdomyolysis, etc. since the acid addition salt is excellent in physicochemical properties such as solubility, stability, non-hygroscopicity, anti-adhering property, etc., and low toxicity, a method of preparing the same and a pharmaceutical composition comprising the same.

    摘要翻译: 本发明涉及N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物,更具体地涉及作为结晶酸加成盐的N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其是由 使N,N-二甲基亚氨基二亚甲基二酰胺与乙酸反应,作为治疗代谢综合征的糖尿病,糖尿病,肥胖症,高脂血症,脂肪肝,冠心病,骨质疏松症,多囊卵巢综合症,癌症, 贫血基因P53等复杂发生; 治疗糖尿病并预防其并发症; 并且由于酸加成盐在溶解性,稳定性,非吸湿性,抗附着性等等的物理化学性质和低毒性方面都是优异的,因此治疗癌症并防止肌肉痛,肌肉细胞毒性和横纹肌溶解等。 的制备方法和包含其的药物组合物。

    N, N -DIMETHYL IMIDODICARBONIMIDIC DIAMIDE ACETATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
    4.
    发明申请
    N, N -DIMETHYL IMIDODICARBONIMIDIC DIAMIDE ACETATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 有权
    N,N-二甲基咪唑二羧酸二乙酸酯,其制备方法和包含其的药物组合物

    公开(公告)号:US20100087544A1

    公开(公告)日:2010-04-08

    申请号:US12524695

    申请日:2008-01-29

    CPC分类号: A61K31/155 C07C279/26

    摘要: The present invention relates to N,N-dimethyl imidodicarbonimidic diamide acetate, a method of preparing the same and a pharmaceutical composition comprising the same, and more particularly, to N,N-dimethyl imidodicarbonimidic diamide acetate which is a crystalline acid addition salt prepared by reacting N,N-dimethyl imidodicarbonimidic diamide with acetic acid, and which is very effective as a therapeutic agent for treating metabolic syndromes that glycosuria and diabetes mellitus, obesity, hyperlipidemia, fatty liver, coronary heart disease, osteoporosis, polycystic ovarian syndrome, a cancer depleted of gene P53, etc. are complexly occurred; treating diabetes mellitus and preventing its complication; and treating a cancer and preventing myalgia, muscle cell cytotoxicity and rhabdomyolysis, etc. since the acid addition salt is excellent in physicochemical properties such as solubility, stability, non-hygroscopicity, anti-adhering property, etc., and low toxicity, a method of preparing the same and a pharmaceutical composition comprising the same.

    摘要翻译: 本发明涉及N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物,更具体地涉及作为结晶酸加成盐的N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其是由 使N,N-二甲基亚氨基二亚甲基二酰胺与乙酸反应,作为治疗代谢综合征的糖尿病,糖尿病,肥胖症,高脂血症,脂肪肝,冠心病,骨质疏松症,多囊卵巢综合征,癌症, 贫血基因P53等复杂发生; 治疗糖尿病并预防其并发症; 并且由于酸加成盐在溶解性,稳定性,非吸湿性,抗附着性等等的物理化学性质和低毒性方面都是优异的,因此治疗癌症并防止肌肉痛,肌肉细胞毒性和横纹肌溶解等。 的制备方法和包含其的药物组合物。

    N,N-dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same
    5.
    发明授权
    N,N-dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same 有权
    N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物

    公开(公告)号:US08541474B2

    公开(公告)日:2013-09-24

    申请号:US13241731

    申请日:2011-09-23

    CPC分类号: A61K31/155 C07C279/26

    摘要: The present invention relates to N,N-dimethyl imidodicarbonimidic diamide acetate, a method of preparing the same and a pharmaceutical composition comprising the same, and more particularly, to N,N-dimethyl imidodicarbonimidic diamide acetate which is a crystalline acid addition salt prepared by reacting N,N-dimethyl imidodicarbonimidic diamide with acetic acid, and which is very effective as a therapeutic agent for treating metabolic syndromes that glycosuria and diabetes mellitus, obesity, hyperlipidemia, fatty liver, coronary heart disease, osteoporosis, polycystic ovarian syndrome, a cancer depleted of gene P53, etc. are complexly occurred; treating diabetes mellitus and preventing its complication; and treating a cancer and preventing myalgia, muscle cell cytotoxicity and rhabdomyolysis, etc. since the acid addition salt is excellent in physicochemical properties such as solubility, stability, non-hygroscopicity, anti-adhering property, etc., and low toxicity, a method of preparing the same and a pharmaceutical composition comprising the same.

    摘要翻译: 本发明涉及N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其制备方法和包含其的药物组合物,更具体地涉及作为结晶酸加成盐的N,N-二甲基亚氨基二甲酰亚胺二酰胺乙酸盐,其是由 使N,N-二甲基亚氨基二亚甲基二酰胺与乙酸反应,作为治疗代谢综合征的糖尿病,糖尿病,肥胖症,高脂血症,脂肪肝,冠心病,骨质疏松症,多囊卵巢综合症,癌症, 贫血基因P53等复杂发生; 治疗糖尿病并预防其并发症; 并且由于酸加成盐在溶解性,稳定性,非吸湿性,抗附着性等等的物理化学性质和低毒性方面都是优异的,因此治疗癌症并防止肌肉痛,肌肉细胞毒性和横纹肌溶解等。 的制备方法和包含其的药物组合物。

    Data transmitting method for opportunity driven multiple access (ODMA) system
    8.
    发明授权
    Data transmitting method for opportunity driven multiple access (ODMA) system 有权
    用于机会驱动多路访问(ODMA)系统的数据传输方法

    公开(公告)号:US07386314B2

    公开(公告)日:2008-06-10

    申请号:US10419516

    申请日:2003-04-21

    申请人: Young Woong Kim

    发明人: Young Woong Kim

    IPC分类号: H04Q7/20

    摘要: A mobile communication system for communicating data with various priorities is provided. The system comprises a transmitting device for transmitting data having a transmission priority, an object mobile communication terminal designated for receiving the data; and a plurality of intermediate mobile communication terminals, wherein at least one of said plurality of intermediate mobile communication terminals receives the data from the transmitting device, determines the priority of the data, and forwards the data to the object mobile communication terminal via a particular communication path based on the priority of the data.

    摘要翻译: 提供了一种用于传送具有各种优先级的数据的移动通信系统。 该系统包括用于发送具有发送优先级的数据的发送装置,被指定用于接收数据的对象移动通信终端; 以及多个中间移动通信终端,其中所述多个中间移动通信终端中的至少一个从所述发送设备接收数据,确定所述数据的优先级,并且经由特定通信将所述数据转发到所述对象移动通信终端 路径基于数据的优先级。

    SUPERCONDUCTING CABLE
    10.
    发明申请
    SUPERCONDUCTING CABLE 有权
    超级电缆

    公开(公告)号:US20130165324A1

    公开(公告)日:2013-06-27

    申请号:US13658092

    申请日:2012-10-23

    IPC分类号: H01B12/06

    摘要: A superconducting cable is provided. The superconducting cable includes a core part including a former disposed at the center of the core part, one or more superconducting conductive layers with each electric phase disposed at the outside of the former in a radial directions, a insulating layer disposed at the outside of each the conductive layer in a radial direction and a shielding layer disposed at the outermost of the insulating layer; and a cryostat disposed at the outside of the core part in a radial direction with first space being interposed therebetween, having a vacuum part disposed therein and electrically wired to neutral pole (N pole).

    摘要翻译: 提供超导电缆。 超导电缆包括芯部,包括设置在芯部的中心的前体,一个或多个超导导电层,每个电相沿着径向设置在前者的外侧,绝缘层设置在每个的外侧 所述导电层在径向方向上,屏蔽层设置在所述绝缘层的最外侧; 以及低温恒温器,其设置在所述芯部的外侧的半径方向上,其间插入有第一空间,其中设置有真空部并与中性极(N极)电连接。