公开(公告)号：US20080242850A1

公开(公告)日：2008-10-02

申请号：US12157120

申请日：2008-06-09

申请人： Chun-Ho Kim ,  Seung-Jae Lee ,  Jin-Ik Lim ,  Youngsook Son

发明人： Chun-Ho Kim ,  Seung-Jae Lee ,  Jin-Ik Lim ,  Youngsook Son

IPC分类号： C08B37/08

CPC分类号： C12N5/0068 ,  A61L15/28 ,  A61L15/425 ,  A61L27/20 ,  A61L27/56 ,  C12N2533/18 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74 ,  C08L5/08

摘要： Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.

摘要翻译： 提供一种生产多孔壳聚糖支架的方法，该方法包括：提供具有壳聚糖的水性酸性溶液和不溶解壳聚糖的溶剂; 并冷冻干燥酸性水溶液，其中溶剂选自具有一个羟基的C 3 -C 8脂族醇，乙二醇单乙醚，乙二醇单丁醚，二恶烷，四氢呋喃，碳酸二甲酯，丙酮和乙腈，和 使用该方法生产壳聚糖支架。

公开(公告)号：US08691973B2

公开(公告)日：2014-04-08

申请号：US12157120

申请日：2007-02-21

申请人： Chun-Ho Kim ,  Seung-Jae Lee ,  Jin-Ik Lim ,  Youngsook Son

发明人： Chun-Ho Kim ,  Seung-Jae Lee ,  Jin-Ik Lim ,  Youngsook Son

IPC分类号： C08B37/08

CPC分类号： C12N5/0068 ,  A61L15/28 ,  A61L15/425 ,  A61L27/20 ,  A61L27/56 ,  C12N2533/18 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C12N2533/74 ,  C08L5/08

摘要： Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.

摘要翻译： 提供一种生产多孔壳聚糖支架的方法，该方法包括：提供具有壳聚糖的水性酸性溶液和不溶解壳聚糖的溶剂; 并冷冻干燥酸性水溶液，其中溶剂选自具有一个羟基的C 3 -C 8脂族醇，乙二醇单乙醚，乙二醇单丁醚，二恶烷，四氢呋喃，碳酸二甲酯，丙酮和乙腈，和 使用该方法生产壳聚糖支架。

公开(公告)号：US20100098671A1

公开(公告)日：2010-04-22

申请号：US12524127

申请日：2007-06-07

申请人： Youngsook Son ,  Hyunsook Hong ,  Jungsun Lee

发明人： Youngsook Son ,  Hyunsook Hong ,  Jungsun Lee

IPC分类号： A61K38/08 ,  C07K7/06 ,  A61K35/12 ,  A61P35/00

CPC分类号： A61K38/08 ,  A61K35/28 ,  A61K2300/00

摘要： Disclosed herein are a composition for prevention or treatment of bone marrow damage comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of a medicament for prevention or treatment of bone marrow damage; a method for prevention or treatment of bone marrow damage comprising administering a therapeutically effective amount of Substance-P to a mammal; an anticancer supplement comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of an anticancer supplement; and a method for prevention or treatment of cancer comprising administering a therapeutically effective amount of Substance-P as an anticancer supplement to a mammal.Substance-P stimulates proliferation of mesenchymal stem cells (MSCs) within the bone marrow to thereby facilitate protection and regeneration of bone marrow cells and hematopoietic stem cells. Therefore, the composition of the present invention can be therapeutically used for treatment and/or prevention of bone marrow damage. Further, the composition of the present invention can be used as an anticancer supplement for anticancer therapy.

摘要翻译： 本文公开了一种用于预防或治疗骨髓损伤的组合物，其包含物质-P作为活性成分; 使用物质-P来制备用于预防或治疗骨髓损伤的药物; 一种预防或治疗骨髓损伤的方法，包括向哺乳动物施用治疗有效量的物质-P; 一种包含物质-P作为活性成分的抗癌补充剂; 使用物质-P制备抗癌补充剂; 以及预防或治疗癌症的方法，包括向哺乳动物施用治疗有效量的作为抗癌剂的物质-P。 物质-P刺激骨髓内的间充质干细胞（MSC）的增殖，从而促进骨髓细胞和造血干细胞的保护和再生。 因此，本发明的组合物可用于治疗和/或预防骨髓损伤。 此外，本发明的组合物可以用作抗癌治疗的抗癌补充剂。