公开(公告)号：US5288706A

公开(公告)日：1994-02-22

申请号：US019347

申请日：1993-02-18

申请人： Toshikazu Yamanouchi ,  Akira Awaya ,  Hisashi Kobayashi ,  Yusaku Ishizuka ,  Hayao Abe

发明人： Toshikazu Yamanouchi ,  Akira Awaya ,  Hisashi Kobayashi ,  Yusaku Ishizuka ,  Hayao Abe

IPC分类号： A61K38/08 ,  A61K37/02 ,  C07K7/06

CPC分类号： A61K38/08 ,  Y10S514/866

摘要： A medicament for prevention and remedy of diseases of pancreas and others is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration:pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asnor an ester and amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.

摘要翻译： PCT No.PCT / JP88 / 01317 Sec。 371日期1989年8月18日 102（e）日期1989年8月18日PCT提交1988年12月23日PCT公布。 出版物WO89 / 06136 公开了一种用于预防和治疗胰腺及其它疾病的药物，其特征在于含有具有以下氨基酸构型的非肽作为其有效成分：pGlu-Ala-Lys-Ser-Gln -Gly-Gly-Ser-Asn或天冬酰胺C末端的羧基上的酯和酰胺或其药理学上可接受的盐。

公开(公告)号：US4963653A

公开(公告)日：1990-10-16

申请号：US372708

申请日：1989-06-28

申请人： Yoshitaka Nagai ,  Shohei Shibayama ,  Masaaki Numata ,  Shoji Yoshimura ,  Makoto Tanaka ,  Masayoshi Ito ,  Akira Awaya ,  Hisashi Kobayashi ,  Hayao Abe ,  Yusaku Ishizuka ,  Tomoya Ogawa

发明人： Yoshitaka Nagai ,  Shohei Shibayama ,  Masaaki Numata ,  Shoji Yoshimura ,  Makoto Tanaka ,  Masayoshi Ito ,  Akira Awaya ,  Hisashi Kobayashi ,  Hayao Abe ,  Yusaku Ishizuka ,  Tomoya Ogawa

IPC分类号： A61K38/22 ,  A61P37/04 ,  B01J23/44 ,  C07B61/00 ,  C07K1/02 ,  C07K1/113 ,  C07K9/00

CPC分类号： C07K9/005 ,  C07K9/001 ,  Y02P20/55

摘要： A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

公开(公告)号：US4952717A

公开(公告)日：1990-08-28

申请号：US131049

申请日：1987-10-20

申请人： Shoichiro Ozaki ,  Yutaka Watanabe ,  Akira Awaya ,  Yusaku Ishizuka

发明人： Shoichiro Ozaki ,  Yutaka Watanabe ,  Akira Awaya ,  Yusaku Ishizuka

IPC分类号： C07C29/00 ,  C07C35/16 ,  C07C43/18 ,  C07C43/188 ,  C07C43/196 ,  C07C43/235 ,  C07D317/46 ,  C07D317/72 ,  C07D493/04 ,  C07F9/117 ,  C07F9/24

CPC分类号： C07C43/196 ,  C07C43/188 ,  C07F9/117

摘要： Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.

公开(公告)号：US5352665A

公开(公告)日：1994-10-04

申请号：US91745

申请日：1993-07-15

申请人： Akira Awaya ,  Hisashi Kobayashi ,  Yusaku Ishizuka ,  Hayao Abe

发明人： Akira Awaya ,  Hisashi Kobayashi ,  Yusaku Ishizuka ,  Hayao Abe

IPC分类号： A61K38/00 ,  C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00

摘要： A medicament for prevention and remedy of diseases caused by the infection of viruses is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration:pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn or an ester and an amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.

摘要翻译： 公开了用于预防和治疗由病毒感染引起的疾病的药物，其特征在于含有具有以下氨基酸构型的非肽作为其有效成分：pGlu-Ala-Lys-Ser-Gln-Gly-Gly- Ser-Asn或天冬酰胺C末端的羧基上的酯和酰胺或其药理学上可接受的盐。

公开(公告)号：US5292913A

公开(公告)日：1994-03-08

申请号：US950760

申请日：1992-09-24

申请人： Shoichiro Ozaki ,  Yutaka Watanabe ,  Akira Awaya ,  Yusaku Ishizuka

发明人： Shoichiro Ozaki ,  Yutaka Watanabe ,  Akira Awaya ,  Yusaku Ishizuka

IPC分类号： C07F9/117

CPC分类号： C07F9/117

摘要： Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.

摘要翻译： 本文公开了由以下通式（I）表示的肌醇的磷酸酯：（*化学结构*）（I）及其盐，以及其制备方法。 肌醇衍生物各自可以通过使磷酸化剂作用于除了希望被磷酸残基取代的那些位置以外的位置上用催化还原可除去取代基取代的肌醇衍生物，然后催化还原由此磷酸化的肌醇来获得。