-
公开(公告)号：US5352665A
公开(公告)日：1994-10-04
申请号：US91745
申请日：1993-07-15
申请人： Akira Awaya , Hisashi Kobayashi , Yusaku Ishizuka , Hayao Abe
发明人： Akira Awaya , Hisashi Kobayashi , Yusaku Ishizuka , Hayao Abe
摘要： A medicament for prevention and remedy of diseases caused by the infection of viruses is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration:pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn or an ester and an amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.
摘要翻译： 公开了用于预防和治疗由病毒感染引起的疾病的药物，其特征在于含有具有以下氨基酸构型的非肽作为其有效成分：pGlu-Ala-Lys-Ser-Gln-Gly-Gly- Ser-Asn或天冬酰胺C末端的羧基上的酯和酰胺或其药理学上可接受的盐。
-
2.发明授权
公开(公告)号：US5288706A
公开(公告)日：1994-02-22
申请号：US019347
申请日：1993-02-18
CPC分类号： A61K38/08 , Y10S514/866
摘要： A medicament for prevention and remedy of diseases of pancreas and others is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration:pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asnor an ester and amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.
摘要翻译： PCT No.PCT / JP88 / 01317 Sec。 371日期1989年8月18日 102（e）日期1989年8月18日PCT提交1988年12月23日PCT公布。 出版物WO89 / 06136 公开了一种用于预防和治疗胰腺及其它疾病的药物，其特征在于含有具有以下氨基酸构型的非肽作为其有效成分：pGlu-Ala-Lys-Ser-Gln -Gly-Gly-Ser-Asn或天冬酰胺C末端的羧基上的酯和酰胺或其药理学上可接受的盐。
-
公开(公告)号：US4963653A
公开(公告)日：1990-10-16
申请号：US372708
申请日：1989-06-28
申请人： Yoshitaka Nagai , Shohei Shibayama , Masaaki Numata , Shoji Yoshimura , Makoto Tanaka , Masayoshi Ito , Akira Awaya , Hisashi Kobayashi , Hayao Abe , Yusaku Ishizuka , Tomoya Ogawa
发明人： Yoshitaka Nagai , Shohei Shibayama , Masaaki Numata , Shoji Yoshimura , Makoto Tanaka , Masayoshi Ito , Akira Awaya , Hisashi Kobayashi , Hayao Abe , Yusaku Ishizuka , Tomoya Ogawa
摘要： A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.
-
公开(公告)号：US5112810A
公开(公告)日：1992-05-12
申请号：US734259
申请日：1985-05-15
申请人： Yoshitaka Nagai , Hayao Abe , Masanobu Arita
发明人： Yoshitaka Nagai , Hayao Abe , Masanobu Arita
CPC分类号： A61K38/08 , Y10S514/885 , Y10S514/903
摘要： A pharmaceutical composition containing serum thymic factor (FTS) and a method for using FTS containing compositions for treating a variety of immunodeficiencies and autoimmune diseases including multiple sclerosis, Guillain-Barre syndrome, inflammatory neuropathy, polyneuritis and other immunodemyelinating diseases.
摘要翻译： 含有血清胸腺因子（FTS）的药物组合物和使用含有FTS的组合物治疗各种免疫缺陷和自身免疫性疾病（包括多发性硬化症，吉兰巴利综合征，炎症性神经病，多发性神经炎和其他免疫缺陷病变）的方法。
-
公开(公告)号：US5464816A
公开(公告)日：1995-11-07
申请号：US498637
申请日：1990-03-26
申请人： Yoshitaka Nagai , Hayao Abe , Masanobu Arita
发明人： Yoshitaka Nagai , Hayao Abe , Masanobu Arita
CPC分类号： A61K38/08 , Y10S514/885 , Y10S514/903
摘要： A pharmaceutical composition containing serum thymic factor (FTS) and a method for using FTS containing compositions for treating a variety of immunodeficiencies and autoimmune diseases including multiple sclerosis, Guillain-Barre syndrome, inflammatory neuropathy, polyneuritis and other immunodemyelinating diseases.
摘要翻译： 含有血清胸腺因子（FTS）的药物组合物和使用含有FTS的组合物治疗各种免疫缺陷和自身免疫性疾病（包括多发性硬化症，吉兰巴利综合征，炎症性神经病，多发性神经炎和其它免疫缺血性疾病）的方法。
-
-
-
-
搜索结果
5 条记录 (耗时 0.017 秒)
