公开(公告)号：US4677295A

公开(公告)日：1987-06-30

申请号：US760678

申请日：1985-07-30

申请人： Serge D. Negra ,  Yvon Le Beyec

发明人： Serge D. Negra ,  Yvon Le Beyec

IPC分类号： G01N27/62 ,  H01J49/16 ,  H01J49/40

CPC分类号： H01J49/16 ,  H01J49/40

摘要： A process for determining mass spectrum by time of flight, wherein a source comprising a solid surface is subjected to the action of an electric field between this surface and an electrode, this provoking the simultaneous emission of electrons and of negative ions released by spontaneous desorption; the electrons and negative ions are received successively by a detector to determine the mass spectrum as a function of the differences between the instants of reception of the electrons and the negative ions.

摘要翻译： 用于通过飞行时间确定质谱的方法，其中包括固体表面的源在该表面和电极之间经受电场的作用，这激发同时发射电子和通过自发解吸释放的负离子; 电子和负离子被检测器连续接收，以确定质谱作为电子和负离子的接收时刻之间的差异的函数。

公开(公告)号：US06989528B2

公开(公告)日：2006-01-24

申请号：US10861962

申请日：2004-06-04

申请人： J. Albert Schultz ,  Michael V. Ugarov ,  Thomas F. Egan ,  Agnes Tempez ,  Yvon Le Beyec ,  Serge Della-Negra

发明人： J. Albert Schultz ,  Michael V. Ugarov ,  Thomas F. Egan ,  Agnes Tempez ,  Yvon Le Beyec ,  Serge Della-Negra

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/164 ,  H01J49/0031 ,  H01J49/0418

摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.

摘要翻译： 本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。 然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析 质谱仪

公开(公告)号：US07629576B2

公开(公告)日：2009-12-08

申请号：US11231448

申请日：2005-09-21

申请人： J. Albert Schultz ,  Michael V. Ugarov ,  Thomas F. Egan ,  Agnes Tempez ,  Yvon Le Beyec ,  Serge D. Negra

发明人： J. Albert Schultz ,  Michael V. Ugarov ,  Thomas F. Egan ,  Agnes Tempez ,  Yvon Le Beyec ,  Serge D. Negra

IPC分类号： H01J49/44

CPC分类号： H01J49/164 ,  H01J49/0031 ,  H01J49/0418

摘要： The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.

摘要翻译： 本发明通过将低能离子簇（金，铝等）或化学衍生的簇离子注入到样品的近表面区域中，形成表面定位的MALDI粒子基质来增强生物分子离子从表面的激光解吸附。 然后可以通过激光解吸到质谱仪中或者在优选的实施方式中将离子迁移正交时间合并在离子迁移正交时间内的表面上或在由离子的注入范围限定的窄地下区域内的完整生物分子的MALDI分析 质谱仪

公开(公告)号：US4694168A

公开(公告)日：1987-09-15

申请号：US706013

申请日：1985-02-27

申请人： Yvon Le Beyec ,  Serge D. Negra

发明人： Yvon Le Beyec ,  Serge D. Negra

IPC分类号： G01N27/62 ,  H01J49/02 ,  H01J49/14 ,  H01J49/40 ,  B01D59/44

CPC分类号： H01J49/405 ,  H01J49/142

摘要： The spectrometer includes an ion source, an ion mirror receiving the ions issued from the source, a first detector placed so as to receive the ions reflected by the mirror and a second detector disposed behind the mirror, all these components forming an assembly of axial symmetry. A reflex spectrum of the ions reflected by the mirror and received by the first detector can be obtained in parallel with a spectrum of the neutral species which may have appeared as a result of in flight decompositions of metastable ions and which are received by the second detector. This arrangement is particularly adapted to the study of metastable ions, processing means being provided for producing correlated reflex spectra where the contributions of ion fragments corresponding to received neutral fragments is enhanced.

摘要翻译： 光谱仪包括离子源，接收从源发出的离子的离子镜，放置以接收由反射镜反射的离子的第一检测器和设置在反射镜后面的第二检测器，所有这些部件形成轴向对称的组件 。 由反射镜反射并由第一检测器接收的离子的反射光谱可以与可能由于亚稳离子的飞行分解而出现并且被第二检测器接收的中性物质的光谱平行地获得 。 这种布置特别适用于亚稳离子的研究，提供处理装置用于产生相关反射光谱，其中对应于接收到的中性碎片的离子片段的贡献增强。