公开(公告)号：US20250049767A1

公开(公告)日：2025-02-13

申请号：US18791971

申请日：2024-08-01

Applicant: Zhaoli Sun ,  John Sun ,  Christy Eatmon ,  Rachel Labell ,  Zhimin Liu ,  Richard Brewer ,  Isaac Agyemang ,  Mitchell Williams

Inventor： Zhaoli Sun ,  John Sun ,  Christy Eatmon ,  Rachel Labell ,  Zhimin Liu ,  Richard Brewer ,  Isaac Agyemang ,  Mitchell Williams

IPC: A61K31/436 ,  A61K9/00 ,  A61K31/495 ,  A61K47/02 ,  A61K47/10 ,  A61K47/22 ,  A61P11/00 ,  A61P29/00

Abstract: Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved stability comprising at least two active ingredients, AMD3100, or similar stem cell mobilizer, and Tacrolimus, or FK506 derivative or analog, and one or more excipients. The formulations may be administered as a single dose subcutaneous injection. The formulations may be useful in treating various diseases, disorders or injuries.

公开(公告)号：US07892489B2

公开(公告)日：2011-02-22

申请号：US11754912

申请日：2007-05-29

Applicant: Hong Wang ,  Zhimin Liu

Inventor： Hong Wang ,  Zhimin Liu

IPC: G01N21/00 ,  G01N21/03 ,  G01J3/44

CPC classification number: G01N21/658

Abstract: A micro structure includes a silicon substrate, an adhesion layer on the silicon substrate, a bias layer on the adhesion layer, and structure layers on the adhesion layer. The two or more structure layers comprise different material compositions and a plurality of holes through at least two of the structure layers. Widths of the plurality of holes are in the range of 0.5-500 nm.

Abstract translation: 微结构包括硅衬底，硅衬底上的粘合层，粘合层上的偏置层和粘合层上的结构层。 两个或更多个结构层包括不同的材料组成和通过至少两个结构层的多个孔。 多个孔的宽度在0.5〜500nm的范围内。

公开(公告)号：US06469835B1

公开(公告)日：2002-10-22

申请号：US09704113

申请日：2000-10-30

Applicant: Zhimin Liu

Inventor： Zhimin Liu

IPC: G02B2730

CPC classification number: G02B6/32 ,  G02B27/30

Abstract: This invention discloses an optical collimator lens for collimating an incident light. The collimator lens includes an optical transmission rod substantially formed as an elongated cylinder. The optical transmission rod further includes a first end surface formed as a spherical or aspherical end surface and a second end surface opposite the first end-surface. The second end surface formed as an inclined planar surface having an incline angle &thgr; relative to the optical axis of the optical transmission rod for increasing a return loss from the inclined planar surface. In a preferred embodiment, the inclined planar surface has an incline angle of substantially eight degrees or less or more.

Abstract translation: 本发明公开了一种准直入射光的准直透镜。 准直透镜包括基本形成为细长圆筒的光传输杆。 光传输杆还包括形成为球面或非球面端面的第一端面和与第一端面相对的第二端面。 第二端面形成为相对于光传输杆的光轴具有倾斜角θ的倾斜平面，用于增加从倾斜平面的返回损耗。 在优选实施例中，倾斜平面的倾斜角度大致为八度以下。

公开(公告)号：US06400508B1

公开(公告)日：2002-06-04

申请号：US09695766

申请日：2000-10-24

Applicant: Zhimin Liu

Inventor： Zhimin Liu

IPC: G02B530

CPC classification number: G02B6/272 ,  G02B6/2766 ,  G02B6/29302 ,  G02B6/29386 ,  G02B6/29398

Abstract: This invention discloses an optical interleaver. The optical interleaver includes an input port for receiving an input light beam including a plurality of wavelengths represented by &lgr;1, &lgr;2, &lgr;3, . . . , &lgr;n where n is a positive integer. The interleaver further includes a group of optical elements for decomposing the input light beam into a first light beam including a first set of wavelengths represented by &lgr;1, &lgr;3, &lgr;5, . . . , &lgr;n and a second light beam including of a second set of wavelengths represented by &lgr;2, &lgr;4, &lgr;6, . . . , &lgr;n−1, wherein the first light beam and the second light beam transmitted respectively in a first and second optical paths, and the group of optical elements further decomposing and generating two sets of mutually orthogonally polarized and parallel beam-components from the first beam and second beam. The interleaver further includes an incline angle means coupled to the group of optical elements. The incline angle means is used for projecting the two sets of mutually orthogonally polarized and parallel beam-components for the first and second beams respectively with a first incline angle and second incline angle relative to an optical axis of the interleaver. And, the interleaver further includes an output beam-component combining means for combining the mutual orthogonally polarized and parallel beam-components into a first output beam and a second output beam projected with the first and second incline angles respectively relative to the optical axis of the interleaver. In a preferred embodiment, the interleaver further includes a dual fiber collimator having a first optical fiber and a second optical fiber disposed off-axis of the collimator for directly receiving the first output beam and the second output beam projected respectively with the first and second inclined angles.

Abstract translation: 本发明公开了一种光交错器。 光交错器包括用于接收包括由lambd1，lambd2，lambd3表示的多个波长的输入光束的输入端口。 。 。 ，lambdn其中n是正整数。 交织器还包括用于将输入光束分解成包括由lambd1，lambd3，lambd5表示的第一组波长的第一光束的一组光学元件。 。 。 ，lambdn和包含由lambd2，lambd4，lambd6表示的第二组波长的第二光束。 。 。 lambdn-1，其中所述第一光束和所述第二光束分别在第一和第二光路中传输，并且所述光学元件组进一步从所述第一光束分解和产生两组相互正交极化和平行的光束分量 和第二光束。 交织器还包括耦合到该组光学元件的倾斜角度装置。 倾斜角度装置用于相对于交织器的光轴以第一倾斜角度和第二倾斜角度分别投影用于第一和第二光束的两组相互正交偏振和平行光束分量的组。 并且，交织器还包括输出光束分量组合装置，用于将互相正交偏振和平行光束分量组合成第一输出光束和第二输出光束，第一输出光束和第二输出光束分别相对于第一输出光束的光轴投影第一和第二倾斜角度 交织器。 在优选实施例中，交织器还包括具有第一光纤的双光纤准直仪和设置在准直器离轴的第二光纤，用于直接接收第一和第二倾斜的第一输出光束和第二输出光束， 角度。

公开(公告)号：US07242469B2

公开(公告)日：2007-07-10

申请号：US10987842

申请日：2004-11-12

Applicant: Hong Wang ,  Zhimin Liu

Inventor： Hong Wang ,  Zhimin Liu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658 ,  G08B21/12

Abstract: New and improved applications of Raman Scattering are disclosed. These applications may be implemented with or without using an enhanced nano-structured surface that is trademarked as the RamanNanoChip™ disclosed in a pending patent. As a RamanNanoChip™ provides much higher sensitivity in SERS compared with conventional enhance surface, broader scopes of applications are now enabled and can be practically implemented as now disclosed in this application. Furthermore, a wide range of applications is achievable as new and improved Raman sensing applications. By applying the analysis of Raman scattering spectrum, applications can be carried out to identify unknown chemical compositions to perform the tasks of homeland security; food, drug and drinking materials safety; early disease diagnosis; environmental monitoring; industrial process monitoring, precious metal and gem authentications, etc.

Abstract translation: 公开了拉曼散射的新的和改进的应用。 这些应用可以在使用或不使用商标为未决专利中公开的RamanNanoChip TM的增强型纳米结构化表面的情况下实现。 由于与传统增强表面相比，RamanNanoChip（TM）在SERS中提供了更高的灵敏度，因此现在可以实现更广泛的应用范围，并且可以实际实现，如本应用中所公开的。 此外，作为新的和改进的拉曼传感应用可以实现广泛的应用。 通过应用拉曼散射光谱分析，可以应用于识别未知化学成分来执行国土安全任务; 食品，药品和饮料安全; 早期疾病诊断; 环境监测; 工业过程监控，贵金属和宝石认证等

公开(公告)号：US20050206892A1

公开(公告)日：2005-09-22

申请号：US10987842

申请日：2004-11-12

Applicant: Hong Wang ,  Zhimin Liu

Inventor： Hong Wang ,  Zhimin Liu

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658 ,  G08B21/12

Abstract: New and improved applications of Raman Scattering are disclosed. These applications may be implemented with or without using an enhanced nano-structured surface that is trademarked as the RamanNanoChip™ disclosed in a pending patent. As a RamanNanoChip™ provides much higher sensitivity in SERS compared with conventional enhance surface, broader scopes of applications are now enabled and can be practically implemented as now disclosed in this application. Furthermore, a wide range of applications is achievable as new and improved Raman sensing applications. By applying the analysis of Raman scattering spectrum, applications can be carried out to identify unknown chemical compositions to perform the tasks of homeland security; food, drug and drinking materials safety; early disease diagnosis; environmental monitoring; industrial process monitoring, precious metal and gem authentications, etc.

Abstract translation: 公开了拉曼散射的新的和改进的应用。 这些应用可以在使用或不使用商标为未决专利中公开的RamanNanoChip TM的增强型纳米结构化表面的情况下实现。 由于与传统增强表面相比，RamanNanoChip（TM）在SERS中提供了更高的灵敏度，因此现在可以实现更广泛的应用范围，并且可以实际实现，如本应用中所公开的。 此外，作为新的和改进的拉曼传感应用可以实现广泛的应用。 通过应用拉曼散射光谱分析，可以应用于识别未知化学成分来执行国土安全任务; 食品，药品和饮料安全; 早期疾病诊断; 环境监测; 工业过程监控，贵金属和宝石认证等

公开(公告)号：US06438278B1

公开(公告)日：2002-08-20

申请号：US09239203

申请日：1999-01-28

Applicant: Zhimin Liu ,  Jiwu Ling

Inventor： Zhimin Liu ,  Jiwu Ling

IPC: G02B600

CPC classification number: G02B6/2746 ,  G02B27/283

Abstract: A fiber optical circulator in which is a light beam is fed from a fiber of a first port in a dual core glass capillary, then collimated before being passed to a birefringent crystal wherein the light beam is divided into two orthogonal components o and e with a displacement. The State of Polarization (SOP) of components then are changed into the same, perpendicular to the incident plane of the birefringent crystal prism by the group of Faraday Rotator and two Half-Wave Plates (HWP) that have different optical axis orientation and cover o and e components respectively. Then the light components with the same SOP pass into a birefringent prism where they receive angle correction to meet receiving requirement in incident angle for the fiber of port 2 without displacement due to their SOP. This is followed by a second group of HWP and Faraday Rotator that changes the SOP of two components back to orthogonal. The light beam of components then pass into the second birefringent crystal which combines the o and e components together and pass through collimator lens, and are received by optical fiber of the second port. The optical path from the second port to the third port is similar to that described above. However, due to the non-reciprocal property of the Faraday Rotator, the SOP of the two light components from the second port will be in the incident plane of the crystal prism, therefore receive a displacement after the birefringent crystal prism. This displacement combined with angle correction allows the light from the second port is fed into the fiber of the third port. An alternative design uses a pair of glass prism and a plane crystal to replace the function of crystal prism in the preferred embodiment.

Abstract translation: 其中是光束的光纤循环器从双芯玻璃毛细管中的第一端口的光纤馈送，然后在被传送到双折射晶体之前被准直，其中光束被分成两个正交分量o和e，其中a 移位。 通过法拉第旋转器组和两个具有不同光轴取向的半波片（HWP）垂直于双折射晶体棱镜的入射平面，组件的极化状态（SOP）变为相同，覆盖o 和e组件。 然后具有相同SOP的光分量进入双折射棱镜，在那里它们接收角度校正，以满足端口2的光纤的入射角的接收要求，由于它们的SOP而没有位移。 之后是第二组HWP和法拉第旋转器，将两个组件的SOP改为正交。 分量光束然后进入第二双折射晶体，其将o和e分量结合在一起并通过准直透镜，并由第二端口的光纤接收。 从第二端口到第三端口的光路与上述类似。 然而，由于法拉第旋转器的不可逆性，来自第二端口的两个光分量的SOP将在晶体棱镜的入射平面中，因此在双折射晶体棱镜之后接收位移。 该位移与角度校正相结合允许来自第二端口的光被馈送到第三端口的光纤中。 在优选实施例中，替代设计使用一对玻璃棱镜和平面晶体来代替晶体棱镜的功能。

公开(公告)号：US06310989B1

公开(公告)日：2001-10-30

申请号：US09238013

申请日：1999-01-26

Applicant: Zhimin Liu

Inventor： Zhimin Liu

IPC: G02B634

CPC classification number: G02B6/2746 ,  G02F1/093

Abstract: A fiber optical circulator wherein optical fibers of three ports share one glass capillary, one collimator lens and one walk-off crystal. Three optical fibers lie on a plane in a glass capillary that is aligned with a collimator lens concentrically. A light fed into the fiber of port 1, which is off optical axis of collimator lens, is collimated with an angle &thgr; to the axis of collimate lens. The collimated beam is divided into two orthogonal components by a first crystal. A device group consisting of one Faraday rotator and one pair of Half Wave Plates transfers the State Of Polarization (SOP) of two components into the same. The angled part of a combined prism bent both beams to be parallel to optical axis of system. The lights pass through a second crystal without displacement due to their SOP. Their SOP receive 90° rotations by a round trip in followed Faraday rotator with help of a reflection film on the backside or a mirror. The light components receive a displacement onto optical axis after the second crystal due to their rotated SOP, pass through the flat part of combined prism, changes their SOP with help of the group of Rotator and wave plate, combined into one beam by the first crystal, and is focused into the fiber of port 2 by collimate lens. The process of port 2 to port 3 is similar to above. The light fed into fiber of port 2 is collimated to be parallel to the optical axis. The collimated beams pass though all parts then reflected by the reflection film or mirror. The light beam in return path receives a displacement by the second crystal and bending angle by the angled part of combined prism. The light is finally focused into the fiber of port 3 by the collimate lens. Since this circulator requires less optical parts, it achieves compact size and low cost simultaneously.

Abstract translation: 一种光纤循环器，其中三个端口的光纤共用一个玻璃毛细管，一个准直透镜和一个离去晶体。 三根光纤位于与准直透镜同心对准的玻璃毛细管中的平面上。 馈送到位于准直透镜的光轴的端口1的光纤的光被准直与准直透镜的轴线成角度θ。 准直束由第一晶体分成两个正交分量。 由一个法拉第旋转器和一对半波片组成的器件组将两个组件的极化状态转移到同一个。 组合棱镜的倾斜部分将两个梁弯曲成平行于系统的光轴。 由于它们的SOP，灯光通过第二个晶体而没有位移。 他们的SOP通过后面的法拉第旋转器的往返接收90度旋转，帮助背面的反射膜或镜子。 光分量由于旋转的SOP而在第二晶体之后在光轴上接收位移，穿过组合棱镜的平坦部分，借助于旋转器和波片的组，改变其SOP，由第一晶体组合成一个光束 ，并通过准直透镜聚焦到端口2的光纤。 端口2到端口3的过程与上述类似。 进入端口2的光纤的光被准直以平行于光轴。 准直光束通过所有部分，然后被反射膜或反射镜反射。 返回路径中的光束由组合棱镜的倾斜部分接收第二晶体的位移和弯曲角度。 光通过准直透镜最终聚焦在端口3的光纤中。 由于该循环器需要较少的光学部件，因此同时实现了紧凑的尺寸和低成本。

公开(公告)号：US20110140209A1

公开(公告)日：2011-06-16

申请号：US13030274

申请日：2011-02-18

Applicant: Hong Wang ,  Zhimin Liu

Inventor： Hong Wang ,  Zhimin Liu

IPC: H01L29/66 ,  H01L21/302

CPC classification number: G01N21/658

Abstract: A micro structure for sensing a substance using light scattering includes a substrate, a first layer on the substrate, wherein the first layer comprises a metallic material, a second layer over the first layer, and a mask layer over the second layer. A plurality of nano holes are formed through the mask layer and the second layer, wherein the plurality of holes are defined in part by internal surfaces on the second layer and the mask layer. Two or more structure layers are formed on the mask layer and the internal surfaces in the plurality of holes. The two or more structure layers comprise different material compositions.

Abstract translation: 用于使用光散射感测物质的微结构包括基底，基底上的第一层，其中第一层包括金属材料，第一层上的第二层和第二层上的掩模层。 通过掩模层和第二层形成多个纳米孔，其中多个孔部分地由第二层上的内表面和掩模层限定。 在掩模层和多个孔中的内表面上形成两层以上的结构层。 两个或多个结构层包括不同的材料组成。

公开(公告)号：US07428046B2

公开(公告)日：2008-09-23

申请号：US11681157

申请日：2007-03-01

Applicant: Hong Wang ,  Zhimin Liu

Inventor： Hong Wang ,  Zhimin Liu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658 ,  G08B21/12

Abstract: New and improved applications of Raman Scattering are disclosed. These applications may be implemented with or without using an enhanced nano-structured surface that is trademarked as the RamanNanoChip™ disclosed in a pending patent. As a RamanNanoChip™ provides much higher sensitivity in SERS compared with conventional enhance surface, broader scopes of applications are now enabled and can be practically implemented as now disclosed in this application. Furthermore, a wide range of applications is achievable as new and improved Raman sensing applications. By applying the analysis of Raman scattering spectrum, applications can be carried out to identify unknown chemical compositions to perform the tasks of homeland security; food, drug and drinking materials safety; early disease diagnosis environmental monitoring; industrial process monitoring, precious metal and gem authentications, etc.

Abstract translation: 公开了拉曼散射的新的和改进的应用。 这些应用可以在使用或不使用商标为未决专利中公开的RamanNanoChip TM的增强型纳米结构化表面的情况下实现。 由于与传统增强表面相比，RamanNanoChip（TM）在SERS中提供了更高的灵敏度，因此现在可以实现更广泛的应用范围，并且可以实际实现，如本应用中所公开的。 此外，作为新的和改进的拉曼传感应用可以实现广泛的应用。 通过应用拉曼散射光谱分析，可以应用于识别未知化学成分来执行国土安全任务; 食品，药品和饮料安全; 早期疾病诊断环境监测; 工业过程监控，贵金属和宝石认证等