公开(公告)号：US20240168047A1

公开(公告)日：2024-05-23

申请号：US18512809

申请日：2023-11-17

Applicant: 10x Genomics, Inc.

Inventor： Eric EVJE ,  Hendricus MARINDRA ,  Xin YAO

IPC: G01N35/10

CPC classification number: G01N35/10

Abstract: A bottle connection assembly is configured to seal a bottle and provide a fluidic path between the interior of the bottle and its exterior for drawing fluids therefrom. The fluids can be reagents used for preparing a sample for the identification of target molecules. A bottle cap for capping the bottle is positioned below the bottle interface assembly and includes a female fitting configured to engage with a male fitting of the bottle interface assembly to form a sealed fluidic connection.

公开(公告)号：US20240157365A1

公开(公告)日：2024-05-16

申请号：US18507360

申请日：2023-11-13

Applicant: 10x Genomics, Inc.

Inventor： Jack HERRERA ,  Hendricus MARINDRA ,  Denis PRISTINSKI

IPC: B01L3/00 ,  F25B21/00

CPC classification number: B01L3/50851 ,  F25B21/00 ,  B01L2300/1894

Abstract: The present disclosure relates to systems and methods for thermal management of well plates. In various embodiments, an apparatus for performing thermal management includes a thermal transfer block configured to receive a well plate having a plurality of wells, wherein the thermal transfer block comprises a base and a plurality of protrusions arranged on a first side of the base in a configuration such that each of the plurality of wells is received between a set of adjacent protrusions, and wherein each protrusion of the set of adjacent protrusions has a surface that substantially matches a portion of an outer surface of each well that is received between the set of adjacent protrusions; and a cooling block disposed in contact with a second side of the base of the thermal transfer block, wherein the cooling block comprises a heat sink having a plurality of fins immersed in a fluid for cooling.

公开(公告)号：US20240167939A1

公开(公告)日：2024-05-23

申请号：US18507648

申请日：2023-11-13

Applicant: 10x Genomics, Inc.

Inventor： Evan DeJARNETTE ,  Tyler DRAKE ,  Hendricus MARINDRA ,  Jack HERRERA ,  Eric EVJE ,  Alexander Post KINDWALL ,  David MORGAN

IPC: G01N21/03 ,  G01N21/75 ,  H05K7/20

CPC classification number: G01N21/0332 ,  G01N21/75 ,  H05K7/20281

Abstract: Various embodiments of the present disclosure disclose methods and systems for heat exchange in an opto-fluidic instrument. The opto-fluidic instrument includes a sample interface module (SIM), an illumination module, a camera module, and a reagent deck. A coolant from a coolant reservoir is directed into one or more of the modules so that heat exchange occurs at each module with the coolant. The heated coolant from the one or more modules flows to a radiator for cooling, for example, with fans flowing ambient air over the radiator, before the cooled coolant is returned to the coolant reservoir for subsequent use in cooling the modules.

公开(公告)号：US20230271190A1

公开(公告)日：2023-08-31

申请号：US18175885

申请日：2023-02-28

Applicant: 10x Genomics, Inc.

Inventor： Hendricus MARINDRA ,  Denis Pristinski ,  David Morgan ,  Siyuan Xing

IPC: B01L9/00

CPC classification number: B01L9/00 ,  B01L2200/025 ,  B01L2200/04

Abstract: Devices (e.g., flow cell holders) and methods for flow cell assembly and disassembly are provided. The flow cell holders and methods can be used to join or separate the bottom and top layers of a flow cell.