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公开(公告)号：US20240159292A1
公开(公告)日：2024-05-16
申请号：US18505635
申请日：2023-11-09
Applicant: 10x Genomics, Inc.
Inventor： Vu Huy NGUYEN , Denis PRISTINSKI , David MORGAN , Evan DEJARNETTE , Tyler DRAKE , David HOFFMAN
IPC: F16F15/027
CPC classification number: F16F15/027 , F16F2228/04
Abstract: Various embodiments of the present disclosure disclose mitigating internal and external vibrational disturbances in opto-fluidic instrument. In various embodiments, the resonance frequency ranges and/or the vibrational frequency ranges of various modules and components of the opto-fluidic instrument may be selected to avoid resonances from occurring in the opto-fluidic instrument, thereby mitigating vibrations from internal and external sources that may distort the imaging of samples in the opto-fluidic instrument.
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公开(公告)号：US20240157365A1
公开(公告)日：2024-05-16
申请号：US18507360
申请日：2023-11-13
Applicant: 10x Genomics, Inc.
Inventor： Jack HERRERA , Hendricus MARINDRA , Denis PRISTINSKI
CPC classification number: B01L3/50851 , F25B21/00 , B01L2300/1894
Abstract: The present disclosure relates to systems and methods for thermal management of well plates. In various embodiments, an apparatus for performing thermal management includes a thermal transfer block configured to receive a well plate having a plurality of wells, wherein the thermal transfer block comprises a base and a plurality of protrusions arranged on a first side of the base in a configuration such that each of the plurality of wells is received between a set of adjacent protrusions, and wherein each protrusion of the set of adjacent protrusions has a surface that substantially matches a portion of an outer surface of each well that is received between the set of adjacent protrusions; and a cooling block disposed in contact with a second side of the base of the thermal transfer block, wherein the cooling block comprises a heat sink having a plurality of fins immersed in a fluid for cooling.
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公开(公告)号：US20220228210A1
公开(公告)日：2022-07-21
申请号：US17565047
申请日：2021-12-29
Applicant: 10x Genomics, Inc.
Inventor： David Michael PATTERSON , Denis PRISTINSKI , Preyas SHAH , Steven William SHORT , Dieter WILK , Siyuan XING
IPC: C12Q1/6874 , C12N15/10
Abstract: Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate. Compositions such as nucleic acid arrays produced by the methods are also disclosed. In some embodiments, a method disclosed herein comprises using photoresist for photocontrollable hybridization and/or ligation of nucleic acid molecules, wherein photoresist removal allows hybridization and/or ligation of nucleic acid molecules at the exposed area. A large diversity of barcodes can be created in molecules on the substrate via sequential rounds of light exposure, hybridization, and ligation.
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公开(公告)号：US20240060127A1
公开(公告)日：2024-02-22
申请号：US18343108
申请日：2023-06-28
Applicant: 10x Genomics, Inc.
Inventor： Denis PRISTINSKI , Preyas SHAH , Siyuan XING
IPC: C12Q1/6874 , C12Q1/6876 , G03F7/00
CPC classification number: C12Q1/6874 , C12Q1/6876 , G03F7/0035
Abstract: Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate using a minimal mask scheme. Systems and kits employing the methods are also disclosed. In some embodiments, a method disclosed herein comprises using photomasks and photoresist for photocontrollable hybridization and/or ligation of nucleic acid molecules, wherein photoresist removal allows hybridization and/or ligation of nucleic acid molecules at the exposed area. A large diversity of barcodes can be created in molecules on the substrate via sequential rounds of light exposure, hybridization, and ligation.
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Patent Agency Ranking
公开(公告)号：US20240369471A1
公开(公告)日：2024-11-07
申请号：US18775876
申请日：2024-07-17
Applicant: 10x Genomics, Inc.
Inventor： David HOFFMAN , Denis PRISTINSKI , Rajiv BHARADWAJ , Yiran ZHANG
Abstract: Disclosed are assemblies, systems, and methods for transilluminating a sample disposed within a device. An assembly includes a first optically transparent substrate configured to receive a biological sample, a second optically transparent substrate having a top surface, a bottom surface, and a plurality of sides. The first substrate contacts the top surface of the second substrate. The assembly includes at least one light source configured to illuminate at least one of the plurality of sides of the second substrate and a light scattering layer on the bottom surface of the second substrate. The light scattering layer is configured to scatter light from the light source. The assembly includes a thermal control module coupled to the second substrate and configured to control the temperature of the second substrate.
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公开(公告)号：US20240177348A1
公开(公告)日：2024-05-30
申请号：US18513046
申请日：2023-11-17
Applicant: 10x Genomics, Inc.
Inventor： Anton SHUTOV , Denis PRISTINSKI , Dmitri SIMONIAN
CPC classification number: G06T7/85 , G06T7/74 , G06T2200/04 , G06T2207/10012 , G06T2207/20056
Abstract: A machine vision system for calibrating and/or positioning of various motion control modules of an opto-fluidic instrument/tool/instrument having integrated optics and fluidics modules configured for imaging of biological specimens is disclosed. The machine vision system includes determining 3D positions of an object within a reference coordinate system based on a plurality of stereo-images comprising the object; generating a transformation matrix based on the determined 3D positions of the object with respect to a reference position; and calibrating one or more motion control systems based on the determined transformation matrix. The methods also include determining a 3D position of an object within a reference coordinate system based on a stereo-image of the object; generating a 3D offset value between the determined 3D position and a reference location of the object; updating the 3D position using the 3D offset value; and positioning the object based on the corrected 3D position.
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公开(公告)号：US20240171833A1
公开(公告)日：2024-05-23
申请号：US18509584
申请日：2023-11-15
Applicant: 10x Genomics, Inc.
Inventor： David HOFFMAN , Denis PRISTINSKI , Evan DeJARNETTE , David MORGAN
Abstract: An imaging system includes an optical mounting plate having an aperture disposed between a first portion and a second portion, an imaging sensor disposed on the first portion, an objective lens disposed on the second portion, and an illumination assembly arranged within the aperture and disposed between the imaging sensor and the objective lens. The imaging system includes a heat sink coupled to the illumination assembly and configured to transfer heat away from light sources of the illumination assembly via a working fluid that flows through the heat sink.
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公开(公告)号：US20240171723A1
公开(公告)日：2024-05-23
申请号：US18513143
申请日：2023-11-17
Applicant: 10x Genomics, Inc.
Inventor： Anton SHUTOV , Denis PRISTINSKI
IPC: H04N13/246 , H04N13/207 , H04N13/254
CPC classification number: H04N13/246 , H04N13/207 , H04N13/254
Abstract: An optical assembly of a machine vision system for calibrating and/or positioning of various motion control modules of an analytical system/tool/instrument having integrated optics and fluidics modules configured for imaging of biological specimens is disclosed. The optical assembly includes one or more light sources configured to generate a first light beam and a second light beam that intersects the first light beam at an intersection region to illuminate an object within the intersection region; a sensor array configured to receive the first light beam and the second light beam to thereby form a stereo-image based on received light from the first light beam and the second light beam; a first imaging mirror configured to reflect the first beam after the intersection region and towards the sensor array; and a second imaging mirror configured to reflect the second beam after the intersection region and towards the sensor array.
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公开(公告)号：US20230347312A1
公开(公告)日：2023-11-02
申请号：US18131159
申请日：2023-04-05
Applicant: 10x Genomics, Inc.
Inventor： Yiran ZHANG , Siyuan XING , Denis PRISTINSKI
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2204/00 , B01J2219/00416 , B01J2219/00596 , B01J2219/00632 , B01J2219/00722 , B01J2219/00831 , B01J2219/1233
Abstract: Systems and methods for dispensing a liquid on a substrate are disclosed. The system may be used to coat a substrate and/or a sample (e.g., a biological sample) with a liquid. The system includes a rotating device configured to rotate about an axis and a substrate disposed on the rotating device. The substrate comprises a well configured to hold a liquid and the substrate is positioned on a surface of the rotating device perpendicular to and concentric with the axis. The system further includes a liquid handler configured to dispense the liquid into the well. The rotating device is configured to rotate at a speed sufficient to disperse the liquid within the well.
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