公开(公告)号：US20230015076A1

公开(公告)日：2023-01-19

申请号：US17954026

申请日：2022-09-27

申请人： 123IV, Inc.

发明人： Allen B. Chefitz ,  Rohit Singh

IPC分类号： A61B5/00

摘要： A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants. The classifier outputs an appropriate indicator, preferably in real-time, providing the user with an immediate indication of whether C-19 (or other virus of interest) is present.

公开(公告)号：US12121321B2

公开(公告)日：2024-10-22

申请号：US17954026

申请日：2022-09-27

申请人： 123IV, Inc.

发明人： Allen B. Chefitz ,  Rohit Singh

IPC分类号： A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/6826 ,  A61B5/6888 ,  A61B5/7264 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B2562/0238 ,  A61B2562/0285

摘要： A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants. The classifier outputs an appropriate indicator, preferably in real-time, providing the user with an immediate indication of whether C-19 (or other virus of interest) is present.

公开(公告)号：US20220015700A1

公开(公告)日：2022-01-20

申请号：US17381058

申请日：2021-07-20

申请人： 123IV, Inc.

发明人： Allen B. Chefitz

IPC分类号： A61B5/00 ,  A61B5/1477 ,  A61B5/145 ,  G01N33/569 ,  G01N33/543 ,  G02C7/16 ,  G02C11/00 ,  G02C5/12

摘要： An article of manufacture comprises an optical shade configured for removable attachment to eyewear, e.g., eyeglasses that are retrofitted to include a micro-fluidic tear collector in a nose pad. The optical shade comprises a lens having a lateral flow assay comprising an antibody having an associated fluorescent tag. The fluorescent tag is configured to fluoresce and change a color of the lens upon detection by the flow assay of an antigen that matches the antibody. The antigen comprises viral constituents, such as SARS-CoV-2. The color change of the lens is visible and indicates presence of Covid-19 infection.

公开(公告)号：US20240157560A1

公开(公告)日：2024-05-16

申请号：US18414140

申请日：2024-01-16

申请人： 123IV, Inc.

发明人： Allen B. Chefitz

IPC分类号： B25J9/16 ,  A61M5/142 ,  A61M5/168 ,  B25J9/00 ,  B25J11/00

CPC分类号： B25J9/1674 ,  A61M5/142 ,  A61M5/16831 ,  B25J9/0006 ,  B25J9/1664 ,  B25J11/009 ,  A61M2005/16863 ,  A61M2202/206 ,  A61M2205/18 ,  A61M2205/3303

摘要： A method and system to monitor and autonomously configure an intravascular assembly without medical staff involvement or presence. In this solution, a robotic device is associated with an intravascular assembly, which has tubing through which fluids are delivered intravenously. Monitoring of the tubing is initiated. In response to the monitoring, an errant flow through the tubing is detected; typically, the errant flow results from one of: a kink or twist in the tubing, an air bubble in the tubing, an occlusion or clot in the tubing, and pressure variations. In response to detecting the errant flow, and in advance of an audible alarm being generated in association with the intravascular assembly, a command is then issued to the associated robotic device. The command is configured to initiate, by the robotic device, physical engagement with and mechanical manipulation of the tubing, thereby remediating the errant flow automatically.

公开(公告)号：US11304605B2

公开(公告)日：2022-04-19

申请号：US17079649

申请日：2020-10-26

申请人： 123IV, Inc.

发明人： Allen B. Chefitz ,  Rohit Singh

IPC分类号： A61B5/00

摘要： A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants. The classifier outputs an appropriate indicator, preferably in real-time, providing the user with an immediate indication of whether C-19 (or other virus of interest) is present.

公开(公告)号：US11452454B2

公开(公告)日：2022-09-27

申请号：US17722681

申请日：2022-04-18

申请人： 123IV, Inc.

发明人： Allen B. Chefitz ,  Rohit Singh

IPC分类号： A61B5/00

摘要： A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants. The classifier outputs an appropriate indicator, preferably in real-time, providing the user with an immediate indication of whether C-19 (or other virus of interest) is present.

公开(公告)号：US20210291370A1

公开(公告)日：2021-09-23

申请号：US17163885

申请日：2021-02-01

申请人： 123IV, Inc.

发明人： Allen B. Chefitz

IPC分类号： B25J9/16 ,  B25J11/00 ,  B25J9/00 ,  A61M5/142 ,  A61M5/168

摘要： A method and system to monitor and autonomously configure an intravascular assembly without medical staff involvement or presence. In this solution, a robotic device is associated with an intravascular assembly, which has tubing through which fluids are delivered intravenously. Monitoring of the tubing is initiated. In response to the monitoring, an errant flow through the tubing is detected; typically, the errant flow results from one of: a kink or twist in the tubing, an air bubble in the tubing, an occlusion or clot in the tubing, and pressure variations. In response to detecting the errant flow, and in advance of an audible alarm being generated in association with the intravascular assembly, a command is then issued to the associated robotic device. The command is configured to initiate, by the robotic device, physical engagement with and mechanical manipulation of the tubing, thereby remediating the errant flow automatically.

公开(公告)号：US10906180B1

公开(公告)日：2021-02-02

申请号：US16880789

申请日：2020-05-21

申请人： 123IV, Inc.

发明人： Allen B. Chefitz

IPC分类号： B25J9/16 ,  B25J11/00 ,  B25J9/00 ,  A61M5/142 ,  A61M5/168

摘要： A method and system to monitor and autonomously configure an intravascular assembly without medical staff involvement or presence. In this solution, a robotic device is associated with an intravascular assembly, which has tubing through which fluids are delivered intravenously. Monitoring of the tubing is initiated. In response to the monitoring, an errant flow through the tubing is detected; typically, the errant flow results from one of: a kink or twist in the tubing, an air bubble in the tubing, an occlusion or clot in the tubing, and pressure variations. In response to detecting the errant flow, and in advance of an audible alarm being generated in association with the intravascular assembly, a command is then issued to the associated robotic device. The command is configured to initiate, by the robotic device, physical engagement with and mechanical manipulation of the tubing, thereby remediating the errant flow automatically.

公开(公告)号：US20220240784A1

公开(公告)日：2022-08-04

申请号：US17722681

申请日：2022-04-18

申请人： 123IV, Inc.

发明人： Allen B. Chefitz ,  Rohit Singh

IPC分类号： A61B5/00

摘要： A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants. The classifier outputs an appropriate indicator, preferably in real-time, providing the user with an immediate indication of whether C-19 (or other virus of interest) is present.

公开(公告)号：US11291408B2

公开(公告)日：2022-04-05

申请号：US17381058

申请日：2021-07-20

申请人： 123IV, Inc.

发明人： Allen B. Chefitz

IPC分类号： G01N33/569 ,  G02C7/16 ,  G01N33/543 ,  A61B5/00 ,  A61B5/1477 ,  A61B5/145 ,  G02C11/00 ,  G02C5/12 ,  A61B10/00

摘要： An article of manufacture comprises an optical shade configured for removable attachment to eyewear, e.g., eyeglasses that are retrofitted to include a micro-fluidic tear collector in a nose pad. The optical shade comprises a lens having a lateral flow assay comprising an antibody having an associated fluorescent tag. The fluorescent tag is configured to fluoresce and change a color of the lens upon detection by the flow assay of an antigen that matches the antibody. The antigen comprises viral constituents, such as SARS-CoV-2. The color change of the lens is visible and indicates presence of Covid-19 infection.