公开(公告)号：US20240279586A1

公开(公告)日：2024-08-22

申请号：US18569525

申请日：2022-05-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Francois Ahimou ,  G. Marco Bommarito ,  Timothy A. Kohman

IPC: C12M1/12 ,  A61L2/28

CPC classification number: C12M37/06 ,  A61L2/28

Abstract: A biological sterilization indicator (BI) is provided. The BI can include a housing, and a container positioned in the housing. The BI can further include a first chamber, and a second chamber with a source of biological activity disposed therein. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity. The substrate can comprise a hydrophobic nonporous film having an aperture. The substrate and the aperture are dimensioned to control fluid flow between the first compartment and the second compartment. The substrate can extend around substantially the entire inner perimeter of the housing between the first compartment and the second compartment.

公开(公告)号：US20170252475A1

公开(公告)日：2017-09-07

申请号：US15601571

申请日：2017-05-22

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Francois Ahimou ,  Assumpta Bennaars-Eiden ,  William E. Foltz ,  Swarnalatha Swaminathan

IPC: A61L2/28 ,  C12Q1/22 ,  C12M1/12

CPC classification number: A61L2/28 ,  A61L2202/13 ,  C12M37/06 ,  C12Q1/22

Abstract: An article and method are provided for assessing the efficacy of a sterilization process. The article comprises an outer container having an interior volume; a dry source of measurable biological activity disposed in the interior volume; and an effective amount of a dry agent for neutralizing a sterilant compound; wherein both the source of measurable biological activity and the agent are in vapor communication with an environment outside the outer container. The method comprises exposing the article to a first sterilant and, optionally, a second sterilant for a period of time and detecting the measurable biological activity.

公开(公告)号：US20230047207A1

公开(公告)日：2023-02-16

申请号：US17758585

申请日：2021-01-14

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Francois Ahimou ,  Kelvin J. Witcher ,  Naiyong Jing ,  Tonya D. Bonilla ,  G. Marco Bommarito

IPC: C12M1/12 ,  C12Q1/22 ,  A61L2/28

Abstract: The present disclosure is directed to self-contained biological indicators wherein a single type of indicator is capable of being used for various sterilization conditions, including sterilization with steam, hydrogen peroxide, and/or ethylene oxide. In some embodiments, a single type of biological indicator is capable of being used for different steam sterilization conditions having varied temperatures and sterilization cycles.

公开(公告)号：US11421261B2

公开(公告)日：2022-08-23

申请号：US15733271

申请日：2018-12-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kelvin J. Witcher ,  Francois Ahimou ,  Naiyong Jing ,  Tonya D. Bonilla ,  Joshua D. Erickson ,  Hsi-Chou Liu ,  Andrew W. Vail

IPC: C12Q1/22 ,  C12Q1/34

Abstract: A method is provided. The method includes providing an article, the article including a nonwoven substrate having a copolymer grafted thereto, the copolymer including interpolymerized monomer units of a quaternary ammonium-containing ligand monomers; an amide monomer; an oxy monomer; and a coating on the nonwoven substrate, the coating including a plurality of test microorganisms, an enzyme or a second substrate; and contacting the article with a detection medium for a period of time.

公开(公告)号：US11065355B2

公开(公告)日：2021-07-20

申请号：US16220395

申请日：2018-12-14

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Francois Ahimou ,  Assumpta A. G. Bennaars-Eiden

IPC: A61L2/28 ,  A61B90/70

Abstract: A device for monitoring the effectiveness of a decontamination process, the device including a bacteria cell as the indicator test organism and optionally a substrate, where the indicator test organism may include a Mycobacteria terrae cell, and methods of using the monitoring device to evaluate the efficacy of a decontamination process.

公开(公告)号：US10947577B2

公开(公告)日：2021-03-16

申请号：US14377203

申请日：2013-02-11

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Francois Ahimou ,  Sailaja Chandrapati ,  Kurt J. Halverson ,  Heather M. Webb ,  Michael G. Williams

IPC: C12Q1/22 ,  G01N21/64

Abstract: A biological sterilization indicator device is provided. The device comprises a body, a plurality of test microorganisms, and an oxygen-modulated first fluorescent sensor. The body comprises a first layer attached to a second layer, forming at least one isolatable microchamber and at least one primary passageway that provides fluidic communication between ambience and the at least one microchamber. The microchamber has an isolated volume of about 0.5 microliters to about 9.5 microliters. The plurality of test microorganisms and the oxygen-modulated first fluorescent sensor are disposed in the microchamber. A method of using the device to determine the effectiveness of a sterilization process is also provided.

公开(公告)号：US10287618B2

公开(公告)日：2019-05-14

申请号：US15129442

申请日：2015-03-24

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Francois Ahimou ,  RuthAnn R. Duda ,  G. Marco Bommarito ,  Timothy J. Nies ,  Kai Qiu

IPC: C12Q1/22 ,  A61L2/28 ,  A61L2/04 ,  A61B90/70 ,  A61L2/18

Abstract: A composition for monitoring the efficacy of a decontamination process is provided, the composition comprising a cellulose polymer and a predetermined quantity of an adenine nucleotide. A monitoring device comprising a test element with the composition disposed thereon is also provided. The composition and/or monitoring device can be used in a method. The method includes exposing the monitoring device to a decontamination process and subsequently measuring the residual tracer analyte on the monitoring device.

公开(公告)号：US09675722B2

公开(公告)日：2017-06-13

申请号：US14770218

申请日：2014-02-20

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Francois Ahimou ,  Assumpta Bennaars-Eiden ,  William E. Foltz ,  Swarnalatha Swaminathan

IPC: A61L2/28 ,  C12Q1/22 ,  C12M1/12

CPC classification number: A61L2/28 ,  A61L2202/13 ,  C12M37/06 ,  C12Q1/22

Abstract: An article and method are provided for assessing the efficacy of a sterilization process. The article comprises an outer container having an interior volume; a dry source of measurable biological activity disposed in the interior volume; and an effective amount of a dry agent for neutralizing a sterilant compound; wherein both the source of measurable biological activity and the agent are in vapor communication with an environment outside the outer container. The method comprises exposing the article to a first sterilant and, optionally, a second sterilant for a period of time and detecting the measurable biological activity.