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公开(公告)号：US11260140B2
公开(公告)日：2022-03-01
申请号：US16341209
申请日：2017-10-12
发明人： G. Marco Bommarito , Timothy J. Nies , Barry W. Robole , Assumpta A. G. Bennaars-Eiden , Jodi L. Connell , Tonya D. Bonilla , Timothy A. Kohman , Ruthann R. Duda
摘要： A microbial indicator device for liquid disinfection comprises a first cavity, a source of biological activity fluidically coupled to the first cavity via a portion of a first fluidic path, a filter membrane positioned in a second fluidic path for a disinfectant, and a first coupling portion fluidically coupled to the source of biologically activity via the second fluidic path. The filter membrane has a first side and a second side, wherein the first side is in fluid communication with the first fluidic path. The filter membrane has a pore size sufficient to retain at least a portion of the source of biological activity on the first side. The device further comprises a frangible container contained in the first cavity, wherein a liquid in the container is in fluid communication with the first cavity when the container is fractured.
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公开(公告)号：US20240307577A1
公开(公告)日：2024-09-19
申请号：US18576785
申请日：2022-07-18
发明人： Stephen B. Roscoe , George W. Griesgraber , Tonya D. Bonilla , Giuseppe M. Bommarito , Wensheng Xia , Jeffrey M. Flynn
IPC分类号： A61L2/28 , A61L2/16 , C07H17/075 , C09K11/06 , C12Q1/22
CPC分类号： A61L2/28 , A61L2/16 , C07H17/075 , C09K11/06 , C12Q1/22
摘要： A chlorinated 4′-alkylumbelliferyl α-D-glucopy-ranoside represented by the structural formula (I) One of R1 and R2 is Cl and the other is H. R3 represents an alkyl group having 1 to 12 carbon atoms. A method of assessing efficacy of a sterilization process including the same is also disclosed.
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公开(公告)号：US20240237971A1
公开(公告)日：2024-07-18
申请号：US18562757
申请日：2022-02-11
发明人： Michael R. Berrigan , Tonya D. Bonilla , Alan R. Dombrowski , Laura R. Nereng , Audrey A. Sherman , Brett J. Sitter , Narina Y. Stepanova , Michael C. Wohl
IPC分类号： A61B10/00
CPC分类号： A61B10/00 , A61B2010/0006 , A61B2010/0087
摘要： A sample collection device includes a housing extending from a mouthpiece end to an air outlet end, the housing defining an airflow channel from the mouthpiece end to the air outlet end, the mouthpiece end configured to receive an exhalation airflow. A porous sample collection media is fixed within the housing and along the airflow channel. A mouthpiece end cap is replaceably coupled to the mouthpiece end and an air outlet end cap is replaceably coupled to the air outlet end.
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公开(公告)号：US20240341627A1
公开(公告)日：2024-10-17
申请号：US18580284
申请日：2022-07-20
发明人： Audrey A. Sherman , Alan R. Dombrowski , Michael R. Berrigan , Brett J. Sitter , Tonya D. Bonilla , Narina Y. Stepanova , Laura R. Nereng , Michael C. Wohl
CPC分类号： A61B5/097 , A61B5/082 , A61B10/0096 , A61B2010/0087
摘要： A protected sample collection media for use in a sample collection device includes a piece of porous sample collection media having a first major side and an opposing second major side; and a protective sheath fully covering the first major side and the second major side. The protective sheath has a first portion and a second portion. The first portion is removable without removing the second portion. The second portion forms a tab constructed to be gripped by hand. The protected sample collection media may be part of a system including a sample collection device. The system may be provided as a kit including instructions for use of the kit.
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公开(公告)号：US20230092755A1
公开(公告)日：2023-03-23
申请号：US17948572
申请日：2022-09-20
发明人： Bharat R. Acharya , Tonya D. Bonilla , Jessica E. DeMay , Stephen M. Kennedy , Aaron M. Marcella , Raj Rajagopal , Mark A. Roehrig , David A. Rosen , Jonah Shaver , Brett J. Sitter , Gregory W. Sitton , Michael L. Steiner , John A. Wheatley , Zhaohui Yang , Antonia E. Schaefer
摘要： A recycling optical cavity is defined at least by first and second optical films and is configured to receive a test material therein. The test material is configured to emit at least a second light having a second wavelength when irradiated with a first light having a first wavelength. For at least one of s- and p-polarized incident lights incident in an incident plane, and at the first and second wavelengths: at a first incident angle, the first optical film has respective optical transmittances T11(θ1) and T12(θ1), and the second optical film has respective optical transmittances T21(θ1) and T22(θ1), wherein T11(θ1)>T12(θ1), T21(θ1), T22(θ1); and at a second incident angle, the first optical film has respective optical transmittances T11(θ2) and T12(θ2), and the second optical film has respective optical transmittances T21(θ2) and T22(θ2), wherein T21(θ2)>T11(θ2), T12(θ2), T22(θ2).
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公开(公告)号：US20220281908A1
公开(公告)日：2022-09-08
申请号：US17637786
申请日：2020-09-04
IPC分类号： C07H17/075 , C12Q1/22 , A61L2/28
摘要： A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4′-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I), wherein R is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.
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公开(公告)号：US20240050951A1
公开(公告)日：2024-02-15
申请号：US18259177
申请日：2021-11-24
发明人： Henrik B. van Lengerich , Caleb T. Nelson , Kayla C. Niccum , Jeffrey L. Solomon , Paul B. Armstrong , Joshua M. Fishman , Tonya D. Bonilla , Phillip D. Hustad , David J. Tarnowski
CPC分类号： B01L3/502761 , G01N21/6428 , B01L3/502707 , G01N2021/6439 , B01L2300/0893 , B01L2300/0819 , B01L2300/0636 , B01L2300/16 , B01L2200/0647
摘要： An article includes a flexible structured film with a first major surface and a second major surface, wherein a first major surface of the flexible structured film has a plurality of posts separated by land areas, and the posts have an exposed surface. An anti-biofouling layer resides in the land areas, and the anti-biofouling layer has a methylated surface. An inorganic layer is on the exposed surfaces of the posts, wherein the inorganic layer includes a metal or a metal oxide. An analyte binding layer is on the inorganic layer, wherein the analyte binding layer is chosen from a reactive silane, a functionalizable hydrogel, a functionalizable polymer, and mixtures and combinations thereof. An exposed surface of the analyte binding layer includes at least one functional group selected to bind with a biochemical analyte.
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公开(公告)号：US20240011975A1
公开(公告)日：2024-01-11
申请号：US18021611
申请日：2021-09-08
发明人： Joshua M. Fishman , Paul B. Armstrong , Caleb T. Nelson , Kayla C. Niccum , Henrik B. van Lengerich , Tonya D. Bonilla , Karl K. Stensvad
IPC分类号： G01N33/53 , G01N33/552 , G01N33/487
CPC分类号： G01N33/5302 , G01N33/552 , G01N33/487
摘要： An article includes a flexible carrier film with a first major surface having an array of structures, at least a portion of which include an inorganic layer and an analyte binding layer. The analyte binding is bonded to the inorganic layer via a network of hydrocarbon linking groups, and the analyte binding layer includes at least one functional group selected to bind with a biochemical analyte. Recessed features interspersed with the structures are free of the inorganic layer and the analyte binding layer.
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公开(公告)号：US11629371B2
公开(公告)日：2023-04-18
申请号：US16475258
申请日：2017-12-22
发明人： Assumpta A. G. Bennaars-Eiden , Tonya D. Bonilla , Jodi L. Connell , John J. Schmidt , Andrew W. Vail , Federica Sgolastra
IPC分类号： G01N15/06 , C12Q1/22 , A61L2/28 , C11D17/04 , A47L13/17 , A61L2/00 , D06M14/26 , D06M14/00 , A01N47/44
摘要： An article is provided. The article comprises a nonwoven substrate having a copolymer grafted thereto, and a dried coating adhered to the substrate. The copolymer comprises interpolymerized monomer units of a quaternary ammonium-containing ligand monomer, an amide monomer, and an oxy monomer. The coating comprises a plurality of test microorganisms. Optionally, the coating further comprises a water-soluble or water-dispersible polymeric binding agent. A process challenge device comprising a body having a hollow channel with said article fixed disposed therein is also provided. Methods of using the article or the process challenge device for determining the efficacy of a disinfection process are also provided.
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公开(公告)号：US12123048B2
公开(公告)日：2024-10-22
申请号：US17298872
申请日：2019-12-03
IPC分类号： C07H17/075 , A61L2/28 , C12Q1/22 , G01N21/64
CPC分类号： C12Q1/22 , A61L2/28 , C07H17/075 , G01N21/6428 , G01N2021/6439
摘要： A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4′-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) wherein one of R1 and R2 is F and the other is H, and R3 is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.
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