公开(公告)号：US12179009B2

公开(公告)日：2024-12-31

申请号：US17734819

申请日：2022-05-02

Applicant: ABIOMED, Inc. ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Ahmad El Katerji ,  Qing Tan ,  Christian Moyer ,  Alexander Ship ,  Sonya Sanat Bhavsar ,  Noam Josephy ,  Elazer R. Edelman ,  Brian Yale Chang ,  Steven Keller

IPC: A61M60/50 ,  A61B5/021 ,  A61B5/0215 ,  A61M60/148 ,  G16H40/63 ,  G16H50/50 ,  A61M60/135

Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

公开(公告)号：US20240006078A1

公开(公告)日：2024-01-04

申请号：US18143630

申请日：2023-05-05

Applicant: ABIOMED, Inc.

Inventor： Ahmad El Katerji ,  Qing Tan ,  Erik Kroeker ,  Rui Wang

IPC: G16H50/50 ,  A61B5/02 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/00 ,  A61M60/422 ,  A61M60/216 ,  A61M60/546 ,  A61M60/122 ,  A61M60/515 ,  A61M60/585 ,  A61M60/538 ,  A61M60/523 ,  A61M60/592 ,  A61M60/531

CPC classification number: G16H50/50 ,  A61B5/02007 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/6852 ,  A61M60/422 ,  A61M60/216 ,  A61M60/546 ,  A61M60/122 ,  A61M60/515 ,  A61M60/585 ,  A61M60/538 ,  A61M60/523 ,  A61M60/592 ,  A61M60/531 ,  A61M2205/04 ,  A61M2205/103 ,  A61M2205/3334 ,  A61M2205/3365 ,  A61M2205/502 ,  A61M2206/10

Abstract: Methods and systems are disclosed for creating and using a neural network model to estimate a cardiac parameter of a patient, and using the estimated parameter in providing blood pump support to improve patient cardiac performance and heart health. Particular adaptations include adjusting blood pump parameters and determining whether and how to increase or decrease support, or wean the patient from the blood pump altogether. The model is created based on neural network processing of data from a first patient set and includes measured hemodynamic and pump parameters compared to a cardiac parameter measured in situ, for example the left ventricular volume measured by millar (in animals) or inca (in human) catheter. After development of a model based on the first set of patients, the model is applied to a patient in a second set to estimate the cardiac parameter without use of an additional catheter or direct measurement.

公开(公告)号：US20230285740A1

公开(公告)日：2023-09-14

申请号：US18120018

申请日：2023-03-10

Applicant: Abiomed, Inc.

Inventor： Mohammed Alwatban ,  Ahmad El Katerji ,  Maxim Daschewski ,  Gerd Spanier ,  Andre Chuev ,  Qing Tan ,  Samuel Brown

IPC: A61M60/538 ,  G01F11/00 ,  A61M60/178 ,  A61M60/216 ,  A61M60/422 ,  F04B51/00

CPC classification number: A61M60/538 ,  G01F11/006 ,  A61M60/178 ,  A61M60/216 ,  A61M60/422 ,  F04B51/00

Abstract: Methods and apparatus for determining flow through a circulatory support device are provided. The method comprises receiving a motor current signal from a motor of the circulatory support device, determining within a time window of the motor current signal, a measured current value at which flow through the circulatory support device is maximum, determining an offset value based, at least in part, on the measured current value, determining based, at least in part, on the received motor current signal, whether an abnormal condition has occurred, adjusting the motor current signal based, at least in part, on the offset value and the determination of whether an abnormal condition has occurred to produce an adjusted motor current signal, and determining the flow through the circulatory support device based, at least in part, on the adjusted motor current signal.

公开(公告)号：US20200222607A1

公开(公告)日：2020-07-16

申请号：US16743797

申请日：2020-01-15

Applicant: Abiomed, Inc.

Inventor： Ahmad El Katerji ,  Qing Tan ,  Erik Kroeker ,  Rui Wang

IPC: A61M1/10 ,  A61B5/02 ,  A61B5/029 ,  A61B5/0215 ,  A61B5/00 ,  G16H50/50

Abstract: Methods and systems are disclosed for creating and using a neural network model to estimate a cardiac parameter of a patient, and using the estimated parameter in providing blood pump support to improve patient cardiac performance and heart health. Particular adaptations include adjusting blood pump parameters and determining whether and how to increase or decrease support, or wean the patient from the blood pump altogether. The model is created based on neural network processing of data from a first patient set and includes measured hemodynamic and pump parameters compared to a cardiac parameter measured in situ, for example the left ventricular volume measured by millar (in animals) or inca (in human) catheter. After development of a model based on the first set of patients, the model is applied to a patient in a second set to estimate the cardiac parameter without use of an additional catheter or direct measurement.

公开(公告)号：US20200146561A1

公开(公告)日：2020-05-14

申请号：US16446427

申请日：2019-06-19

Applicant: Abiomed, Inc. ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital Inc.

Inventor： Qing Tan ,  Ahmad El Katerji ,  Noam Josephy ,  Elazer R. Edelman ,  Brian Yale Chang ,  Steven Keller ,  Sonya Sanat Bhavsar

IPC: A61B5/0215 ,  G16H40/63 ,  G16H50/50 ,  A61B5/021 ,  A61M1/10 ,  A61M1/12

Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

公开(公告)号：US20230355958A1

公开(公告)日：2023-11-09

申请号：US18312032

申请日：2023-05-04

Applicant: Abiomed, Inc.

Inventor： Adrienne Lee ,  Margi Patel ,  Qing Tan

IPC: A61M60/554 ,  A61M60/13 ,  A61M60/216 ,  A61M60/531 ,  A61M60/422

CPC classification number: A61M60/554 ,  A61M60/13 ,  A61M60/216 ,  A61M60/531 ,  A61M60/422 ,  A61M2205/3331 ,  A61M2205/18

Abstract: Methods and apparatus for determining whether a circulatory support device is correctly positioned in a heart of a patient are provided. The method comprises receiving a motor current signal from a motor of the circulatory support device, receiving a pressure signal from a pressure sensor arranged on the circulatory support device, generating a normalized motor current signal based, at least in part, on the pressure signal, determining a pulsatility of the normalized motor current signal, determining whether the circulatory support device is correctly positioned in the heart of the patient based, at least in part, on the pulsatility of the normalized motor current signal, and outputting an alarm when it is determined that the circulatory support device is not correctly positioned in the heart of the patient.

公开(公告)号：US12017076B2

公开(公告)日：2024-06-25

申请号：US17981039

申请日：2022-11-04

Applicant: ABIOMED, Inc.

Inventor： Qing Tan ,  Ahmad El Katerji

IPC: A61N1/362 ,  A61M60/13 ,  A61M60/139 ,  A61M60/216 ,  A61M60/414 ,  A61M60/416 ,  A61M60/531 ,  A61M60/857 ,  A61N1/365 ,  A61N1/39

CPC classification number: A61N1/3629 ,  A61M60/13 ,  A61M60/139 ,  A61M60/216 ,  A61M60/414 ,  A61M60/416 ,  A61M60/531 ,  A61M60/857 ,  A61N1/365 ,  A61N1/3962 ,  A61M2205/3365 ,  A61M2205/502 ,  A61M2230/04

Abstract: A blood pump system includes a catheter, a pump housing disposed distal of a distal end of the catheter, a rotor positioned at least partially in the pump housing, a controller, and an electrode coupled a distal region of the blood pump. The electrode can be used to sense electrocardiogram (EKG) signals and transmit the signals to a controller of the blood pump. The operation of the blood pump can be adjusted based on the EKG signal and on cardiac parameters derived from the EKG signal. Further, the controller can determine a need for defibrillation or pacing of the patient's heart based on the signal and can administer treatment with electrical shocks to the heart via the electrode coupled to the blood pump. The use of an electrode with a blood pump already in place in the heart allows for more efficient and safer treatment of serious cardiac conditions.

公开(公告)号：US20230158309A1

公开(公告)日：2023-05-25

申请号：US17981039

申请日：2022-11-04

Applicant: ABIOMED, Inc.

Inventor： Qing Tan ,  Ahmad El Katerji

IPC: A61N1/362 ,  A61M60/414 ,  A61M60/857 ,  A61N1/365 ,  A61N1/39 ,  A61M60/13 ,  A61M60/139 ,  A61M60/416 ,  A61M60/531 ,  A61M60/216

CPC classification number: A61N1/3629 ,  A61M60/414 ,  A61M60/857 ,  A61N1/365 ,  A61N1/3962 ,  A61M60/13 ,  A61M60/139 ,  A61M60/416 ,  A61M60/531 ,  A61M60/216 ,  A61M2205/3365 ,  A61M2205/502 ,  A61M2230/04

Abstract: A blood pump system includes a catheter, a pump housing disposed distal of a distal end of the catheter, a rotor positioned at least partially in the pump housing, a controller, and an electrode coupled a distal region of the blood pump. The electrode can be used to sense electrocardiogram (EKG) signals and transmit the signals to a controller of the blood pump. The operation of the blood pump can be adjusted based on the EKG signal and on cardiac parameters derived from the EKG signal. Further, the controller can determine a need for defibrillation or pacing of the patient's heart based on the signal and can administer treatment with electrical shocks to the heart via the electrode coupled to the blood pump. The use of an electrode with a blood pump already in place in the heart allows for more efficient and safer treatment of serious cardiac conditions.

公开(公告)号：US20230131738A1

公开(公告)日：2023-04-27

申请号：US17971269

申请日：2022-10-21

Applicant: ABIOMED, Inc.

Inventor： Mohammed Alwatban ,  Maxim Daschewski ,  Qing Tan ,  Andre Chuev ,  Ahmad El Katerji

IPC: A61M60/148 ,  A61M60/178

Abstract: Systems and methods for detecting suction events in blood pumps by monitoring pump motor current. A pump suction event is detected based on a comparison of a pulsatility index that is calculated based on a filtered pump motor current signal with a first predetermined threshold or based on a comparison of a calculated index associated with a normalized band-pass filtered pump motor current signal with a second predetermined threshold. A suction event is also detected based on comparisons of both the calculated pulsatility index and the calculated index associated with the normalized band-pass filtered pump motor current signal with respective first and second predetermined thresholds.

公开(公告)号：US20230390547A1

公开(公告)日：2023-12-07

申请号：US18327957

申请日：2023-06-02

Applicant: Abiomed, Inc.

Inventor： Samuel Brown ,  Qing Tan ,  Mohammed Alwatban

IPC: A61M60/546

CPC classification number: A61M60/546 ,  A61M2205/3334

Abstract: Methods and apparatus for estimating maximum flow for a heart pump are described. The method comprises receiving data relating motor current to differential pressure measured for a predetermined speed of a motor of the heart pump, extrapolating based on the received data, a first value for the motor current at which the differential pressure is zero, and determining a maximum flow value through the heart pump at the predetermined speed of the motor of the heart pump based, at least in part, on the first value for the motor current.