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公开(公告)号：US09834764B2
公开(公告)日：2017-12-05
申请号：US15216039
申请日：2016-07-21
IPC分类号： A61K38/00 , A61K38/46 , C12N9/26 , C12N9/88 , C12N9/24 , C12N9/14 , C12P21/06 , C12P19/34 , C07H21/04 , C07K1/00 , A61K38/51
CPC分类号： C12N9/88 , A61K38/00 , A61K38/51 , C12Y402/02004
摘要： One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
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公开(公告)号：US09410141B2
公开(公告)日：2016-08-09
申请号：US14790075
申请日：2015-07-02
IPC分类号： C12N15/64 , C12P19/34 , C12P21/06 , C12N15/00 , C12N9/88 , C12N9/26 , C12N9/24 , C12N9/14 , C07H21/04 , C07K1/00 , A61K38/00
CPC分类号： A61K38/51 , A61K38/00 , C12N9/88 , C12Y402/0202 , C12Y402/02021
摘要： The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
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公开(公告)号：US09102930B2
公开(公告)日：2015-08-11
申请号：US13849420
申请日：2013-03-22
CPC分类号： A61K38/51 , A61K38/00 , C12N9/88 , C12Y402/0202 , C12Y402/02021
摘要： The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
摘要翻译： 本公开涉及软骨素酶ABCI的蛋白质和核酸突变体。 这种核酸突变体编码表现出改变的软骨素裂解酶活性的软骨素酶ABCI突变体酶或增强的抗应激物包括UV光或热的对灭活的抗性。 还提供了使用编码软骨素酶ABCI突变酶的核酸突变体的方法。
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公开(公告)号：US09402886B2
公开(公告)日：2016-08-02
申请号：US14480486
申请日：2014-09-08
IPC分类号： A61K38/00 , A61K38/47 , A61K38/46 , C12N9/88 , C12N9/26 , C12N9/24 , C12N9/14 , C07H21/04 , C07K1/00 , A61K38/51
CPC分类号： C12N9/88 , A61K38/00 , A61K38/51 , C12Y402/02004
摘要： One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
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公开(公告)号：US10323240B2
公开(公告)日：2019-06-18
申请号：US15789384
申请日：2017-10-20
摘要： One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
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公开(公告)号：US09987340B2
公开(公告)日：2018-06-05
申请号：US15230040
申请日：2016-08-05
IPC分类号： C12N9/88 , C12N9/20 , C12N9/24 , C12N9/14 , C12N15/64 , C12P19/34 , C12P21/06 , C07H21/04 , C07K1/00 , A61M37/00 , A61K38/00 , A61K38/46 , A61K38/51
CPC分类号： A61K38/51 , A61K38/00 , C12N9/88 , C12Y402/0202 , C12Y402/02021
摘要： The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
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