-
公开(公告)号：US20240327443A1
公开(公告)日：2024-10-03
申请号：US18733207
申请日：2024-06-04
发明人： David Y. GIN , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , A61K31/7024 , A61K39/00 , A61K39/02 , A61K39/08 , A61K39/10 , A61K39/39 , A61P31/04 , C07H13/04 , C07H13/06 , C07H13/08 , C07J63/00
CPC分类号： C07H1/00 , A61K31/7024 , A61K39/08 , A61K39/099 , A61K39/39 , A61P31/04 , C07H13/04 , C07H13/06 , C07H13/08 , C07J63/008 , A61K2039/10 , A61K2039/55583
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
-
公开(公告)号：US20230219991A1
公开(公告)日：2023-07-13
申请号：US18180421
申请日：2023-03-08
发明人： David Y. GIN , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , C07H13/04 , A61K39/02 , C07H13/06 , C07H13/08 , A61K31/7024 , C07J63/00 , A61K39/39 , A61P31/04 , A61K39/08 , A61K39/00 , A61K39/10
CPC分类号： C07H1/00 , C07H13/04 , A61K39/099 , C07H13/06 , C07H13/08 , A61K31/7024 , C07J63/008 , A61K39/39 , A61P31/04 , A61K39/08 , A61K2039/55583 , A61K2039/10
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
-
公开(公告)号：US20210002316A1
公开(公告)日：2021-01-07
申请号：US17005110
申请日：2020-08-27
发明人： David Y. GIN , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , C07H13/08 , C07J63/00 , C07H13/04 , C07H13/06 , A61P31/04 , A61K31/7024 , A61K39/08 , A61K39/02 , A61K39/39
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
-
公开(公告)号：US20220275017A1
公开(公告)日：2022-09-01
申请号：US17694180
申请日：2022-03-14
发明人： David Y. GIN , Eric K. CHEA , Alberto FERNANDEZ-TEJADA , Derek S. TAN , Jason S. LEWIS , Jeffrey R. GARDNER , NagaVaraKishore PILLARSETTY
IPC分类号： C07H15/256 , A61K39/39 , A61K45/06 , A61K31/7024 , C07H15/18 , C07H15/24 , A61K31/704
摘要： Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
-
公开(公告)号：US20230357302A1
公开(公告)日：2023-11-09
申请号：US18135592
申请日：2023-04-17
发明人： Derek S. TAN , David Y. GIN , William E. WALKOWICZ , Albertto FERNANDEZ-TEJADA , Govindaswami RAGUPATHI
IPC分类号： C07H15/256 , C07H13/06 , C07J63/00 , C07H15/18
CPC分类号： C07H15/256 , C07H13/06 , C07J63/008 , C07H15/18 , A61K39/39
摘要： A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.
-
公开(公告)号：US20190010181A1
公开(公告)日：2019-01-10
申请号：US16063608
申请日：2016-12-19
发明人： Derek S. TAN , David Y. GIN , William E. WALKOWICZ , Alberto FERNANDEZ-TAJADA , Govindaswami RAGUPATHI
IPC分类号： C07H15/256 , C07H15/18 , C07H13/06
摘要： A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.
-
公开(公告)号：US20170096444A1
公开(公告)日：2017-04-06
申请号：US15314792
申请日：2015-06-01
发明人： David Y. GIN , Eric K. CHEA , Alberto FERNANDEZ-TEJADA , Derek S. TAN , Jason S. LEWIS , Jeffrey R. GARDNER , NagaVarakishore PILLARSETTY
IPC分类号： C07H15/256 , A61K45/06 , A61K31/704 , A61K39/39
CPC分类号： C07H15/256 , A61K31/7024 , A61K31/704 , A61K39/39 , A61K45/06 , A61K2039/55577 , A61K2300/00
摘要： Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.025 秒)
