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    Method and apparatus for Assay of Electrochemical Properties
    3.
    发明申请
    Method and apparatus for Assay of Electrochemical Properties 有权
    电化学性质测定方法和装置

    公开(公告)号：US20140048425A1

    公开(公告)日：2014-02-20

    申请号：US13970117

    申请日：2013-08-19

    申请人： AgaMatrix, Inc.

    发明人： Sridhar G. Iyengar ,  Ian Harding

    IPC分类号： G01N27/416

    CPC分类号： G01N27/26 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/4168

    摘要： The presence of a select analyte in the sample is evaluated in an an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.

    摘要翻译： 在使用导电细胞型装置的电化学系统中评价样品中选择的分析物的存在。 在电池的两个电极之间产生电势或电流，足以使分析物或分析物检测氧化还原系统中的介质发生氧化或还原，由此形成两个电极之间的分析物或介体的化学势梯度 梯度建立后，中止施加的电位或电流，并从化学势梯度的弛豫中获得与分析物无关的信号。 分析物独立信号用于校正在施加电位或电流期间获得的分析物依赖信号。 这种校正允许改进分析物浓度的测量，因为它校正了器件特异性和测试特定因素，例如分析物和/或介体的传输（迁移率），有效电极面积和电极间距（以及结果，样品体积）， 不需要单独的校准值。 可以使用手持式仪表中的一次性测试条进行分析，例如进行葡萄糖测试。

    Method for Determination of Analyte Concentrations and Related Apparatus
    7.
    发明申请
    Method for Determination of Analyte Concentrations and Related Apparatus 有权
    测定分析物浓度的方法及相关仪器

    公开(公告)号：US20150276669A1

    公开(公告)日：2015-10-01

    申请号：US14642982

    申请日：2015-03-10

    申请人： AgaMatrix, Inc.

    发明人： Steven Diamond ,  Ian Harding ,  Sridhar G. Iyengar ,  Baoguo Wei

    IPC分类号： G01N27/416

    CPC分类号： G01N27/4166 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/4161 ,  G01N33/48707

    摘要： A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.

    摘要翻译： 提供了一种用于确定分析物浓度（例如葡萄糖浓度）的方法，其利用动态确定用于进行葡萄糖测量的适当时间，例如当电流对时间曲线基本上符合Cottrell衰变时，或当电流建立时 在高原地区。 动态确定进行测量的时间允许每个条带在最短的适当时间范围内运行，从而避免使用平均测量时间长于某些条带所需的时间，而对于其他条带来说太短。