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公开(公告)号：US12188092B2
公开(公告)日：2025-01-07
申请号：US15557457
申请日：2016-03-09
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Heng-Phon Too , Lihan Zhou , Ruiyang Zou
IPC: C12Q1/6886
Abstract: The present disclosure describes methods of determining the risk of developing breast cancer in a subject or determining whether a subject suffers from breast cancer. The methods can comprise detecting the expression level of microRNAs (miRNAs) hsa-miR-186-5p (SEQ ID NO: 77) and/or hsa-miR-409-3p (SEQ ID NO: 178) in a bodily fluid sample obtained from the subject and determining whether it is upregulated or downregulated as compared to a control, wherein the upregulation of hsa-miR-186-5p (SEQ ID NO: 77) and/or downregulation of hsa-miR-409-3p (SEQ ID NO: 178) indicates that the subject has breast cancer or is at risk of developing breast cancers. Also encompassed are methods of prognosis or diagnosis of breast cancer by detecting expression levels of combinations of miRNAs and using a score based on a panel of miRNA markers.
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公开(公告)号：US11920137B2
公开(公告)日：2024-03-05
申请号：US16488504
申请日：2018-02-26
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Congqiang Zhang , Xixian Chen , Heng-Phon Too
CPC classification number: C12N15/52 , C12N9/0069 , C12N9/90 , C12N15/62 , C12N15/70 , C12P5/026 , C12P7/26 , C12P23/00 , C12Y113/11063 , C12Y113/11068 , C12Y505/01018 , C12Y505/01019
Abstract: A method for producing a carotenoid or apocarotenoid is disclosed. The method comprises the step of expressing in a host cell an expression module comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter. A host cell comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter is also provided together with a kit.
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公开(公告)号：US20230313308A1
公开(公告)日：2023-10-05
申请号：US17713143
申请日：2022-04-04
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , Singapore Health Services Pte Ltd , National University Hospital (Singapore) Pte Ltd , Tan Tock Seng Hospital Pte Ltd , MiRXES Lab Pte. Ltd.
Inventor： Siew Gek Lee-Lim , Ruiyang Zou , Lihan Zhou , He Cheng , Bo Anders Mikael Hartman , Heng-Phon Too
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/178 , C12Q2600/158 , C12Q2600/118
Abstract: This technology relates to a method of treating breast cancer in a subject and a method of determining whether a breast lesion in a subject is malignant or benign using miRNA panels.
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Patent Agency Ranking
公开(公告)号：US20210332345A1
公开(公告)日：2021-10-28
申请号：US17272375
申请日：2019-09-02
Inventor： Congqiang Zhang , Xixian Chen , Ruehl Martin , Heng-Phon Too
Abstract: A bacterial strain comprising one or more vectors encoding a) one or more enzymes to produce one or more terpene precursors; and b) a fungal terpene synthase (FTPS). The present invention also relates to a method of producing a terpenoid comprising a) culturing the bacterial strain described herein in an expression medium; and b) isolating the terpenoid from said expression medium.
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公开(公告)号：US20240175036A1
公开(公告)日：2024-05-30
申请号：US18384044
申请日：2023-10-26
Applicant: Agency for Science, Technology and Research
Inventor： Congqiang Zhang , Xixian Chen , Heng-Phon Too
CPC classification number: C12N15/52 , C12N9/0069 , C12N9/90 , C12N15/62 , C12N15/70 , C12P5/026 , C12P7/26 , C12P23/00 , C12Y113/11063 , C12Y113/11068 , C12Y505/01018 , C12Y505/01019
Abstract: A method for producing a carotenoid or apocarotenoid is disclosed. The method comprises the step of expressing in a host cell an expression module comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter. A host cell comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter is also provided together with a kit.
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公开(公告)号：US11680256B2
公开(公告)日：2023-06-20
申请号：US17272375
申请日：2019-09-02
Inventor： Congqiang Zhang , Xixian Chen , Ruehl Martin , Heng-Phon Too
CPC classification number: C12N9/88 , C12N9/1022 , C12N9/90 , C12P5/002 , C12Y202/01007 , C12Y503/03002
Abstract: A bacterial strain comprising one or more vectors encoding a) one or more enzymes to produce one or more terpene precursors; and b) a fungal terpene synthase (FTPS). The present invention also relates to a method of producing a terpenoid comprising a) culturing the bacterial strain described herein in an expression medium; and b) isolating the terpenoid from said expression medium.
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公开(公告)号：US10100331B2
公开(公告)日：2018-10-16
申请号：US14439330
申请日：2013-10-29
Inventor： Heng-Phon Too , Yoon Khei Ho , Lihan Zhou
IPC: C12N15/87 , C12N15/85 , C12N5/00 , A61K31/7084 , A61K48/00 , A61K31/711 , A61K47/34 , A61K9/127 , A61K39/00
Abstract: The present invention relates to a composition for transfecting a cell with a genetic material comprising a first agent capable of directing the genetic material away from the acidic compartments in the cell and a second agent capable of stabilizing the microtubule or a network thereof. The invention also relates to the use of the composition in the manufacture of a medicament for treating a disease, a method for delivering a genetic material into a cell and a kit.
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公开(公告)号：US20150361449A1
公开(公告)日：2015-12-17
申请号：US14439330
申请日：2013-10-29
Inventor： Heng-Phon Too , Yoon Khei Ho , Lihan Zhou
IPC: C12N15/85
CPC classification number: C12N15/85 , A61K9/1272 , A61K31/711 , A61K39/0011 , A61K47/34 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522 , C12N15/87
Abstract: The present invention relates to a composition for transfecting a cell with a genetic material comprising a first agent capable of directing the genetic material away from the acidic compartments in the cell and a second agent capable of stabilizing the microtubule or a network thereof. The invention also relates to the use of the composition in the manufacture of a medicament for treating a disease, a method for delivering a genetic material into a cell and a kit.
Abstract translation: 本发明涉及一种用遗传材料转染细胞的组合物，其包含能够将遗传物质远离细胞中的酸性隔室的第一种试剂和能够稳定微管或其网络的第二种试剂。 本发明还涉及组合物在制备用于治疗疾病的药物中的用途，将遗传物质递送到细胞和试剂盒中的方法。
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