公开(公告)号：US20180320000A1

公开(公告)日：2018-11-08

申请号：US15769709

申请日：2016-10-19

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yugen ZHANG ,  Yuan YUAN

IPC: C09D5/14 ,  A61K31/4164 ,  A61K47/02 ,  C07F3/06

Abstract: A coating comprising a metal-organic framework, wherein the metal-organic framework having a zeolitic structure comprising at least one multivalent metal species and at least one organic ligand (such as zeolitic imidazolate framework (ZIF)). Said coating has a topography comprising an array of projections, and each projection having at least one tapered distal end. There is also provided a method of coating substrates with the disclosed coating and use of said coating as a disinfectant, an antiseptic, or an antibiotic. Such use is possible because the tapered distal end of the disclosed zeolitic structure exerting higher pressure on any microbial cell that comes into contact with the disclosed coating, thereby piercing through the cell membrane more easily, causing cell deformation and lysis.

公开(公告)号：US20170291877A1

公开(公告)日：2017-10-12

申请号：US15511631

申请日：2015-09-15

Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

Inventor： Yugen ZHANG ,  Siti Nurhanna Binti RIDUAN ,  Yuan YUAN

IPC: C07D233/56 ,  A61K8/49 ,  A01N43/50 ,  A61K8/04 ,  A01N25/04 ,  A61Q17/00

CPC classification number: C07D233/56 ,  A01N25/04 ,  A01N43/50 ,  A61K8/042 ,  A61K8/4946 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/10 ,  A61Q17/005 ,  A01N25/10

Abstract: The present invention relates to antimicrobial imidazolium compounds having the structure of Formula (I) wherein R is an optionally substituted aliphatic group that is linear, cyclic, saturated, unsaturated or any combination thereof; n is an integer of at least 1; and X is an anionic counterion. The present invention also relates to pharmaceutical composition comprising the compound, a gel comprising the compound, uses of the compound as an antibiotic and methods for the preparation of the gels.