公开(公告)号：US20140353493A1

公开(公告)日：2014-12-04

申请号：US13906095

申请日：2013-05-30

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Alexander Mordehai ,  Layne Howard ,  Mark H. Werlich ,  Ruwan T. Kurulugama ,  Thomas A. Knotts

IPC: H01J49/06

CPC classification number: H01J49/062 ,  G01N27/622

Abstract: An interface for an ion mobility spectrometry-mass spectrometry (IMS-MS) system includes a first ion guide for receiving ions from an IMS drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial DC electric field while the second ion guide is held at a lower pressure than the first ion guide. In some embodiments, the first ion guide may be an ion funnel and the second ion guide may be a linear multipole device.

Abstract translation: 用于离子迁移光谱 - 质谱（IMS-MS）系统的界面包括用于从IMS漂移单元接收离子的第一离子引导件和用于接收来自第一离子导向器的离子的第二离子引导件， 从第一离子导向器。 第二离子导向器的电极将离子导向轴向DC电场，而第二离子导向器保持在比第一离子导向器更低的压力下。 在一些实施例中，第一离子导向器可以是离子漏斗，并且第二离子导向器可以是线性多极装置。

公开(公告)号：US09281173B2

公开(公告)日：2016-03-08

申请号：US13906023

申请日：2013-05-30

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Mark H. Werlich ,  Ruwan T. Kurulugama ,  Thomas A. Knotts

IPC: H01J49/06 ,  H01J49/26 ,  G01N27/62

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/26

Abstract: An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage differential may be controlled to avoid voltage breakdown in a low-pressure, high-voltage gas environment. The ion optics device may in some cases be an ion mobility drift cell.

Abstract translation: 离子处理装置包括串联定位并围绕轴线包围体积的导电真空歧管段。 这些段彼此电隔离并且可被电压源独立地寻址。 离子光学器件位于体积中。 每个歧管段和离子光学器件之间的电压差通过向相应的歧管段施加不同的电压而保持在最大值之下。 可以控制电压差以避免在低压，高压气体环境中的电压击穿。 在一些情况下，离子光学器件可能是离子迁移率漂移单元。

公开(公告)号：US20140034827A1

公开(公告)日：2014-02-06

申请号：US13827685

申请日：2013-03-14

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Alexander Mordehai ,  Kenneth R. Newton

IPC: H01J49/00 ,  H01J49/40

CPC classification number: H01J49/02 ,  H01J49/004 ,  H01J49/40 ,  H01J49/429

Abstract: A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer.

Abstract translation: 通过在离子阱中积聚母体离子获得质谱，将所选择的m / z比的母体离子喷射到碰撞池中，从母体离子产生碎片离子，并分析质量分析器中的碎片离子。 其他母体离子保留在离子阱中，因此可以通过从离子阱中大量选择性地扫描母体离子来重复该过程。 以这种方式，可以分析母体离子的全质量范围或完全质量范围的任何所需子集，而没有显着的离子损失或不适当的时间支出。 碰撞池可以提供大的离子接受孔和相对较小的离子发射孔。 碰撞单元可以将离子脉冲输出到质量分析器。 质量分析仪可以是飞行时间分析仪。 从碰撞池中脉冲离子的时间可以与离子脉冲到飞行时间分析仪的时间相匹配。

公开(公告)号：US09455132B2

公开(公告)日：2016-09-27

申请号：US13906095

申请日：2013-05-30

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Layne Howard ,  Mark H. Werlich ,  Ruwan T. Kurulugama ,  Thomas A. Knotts

IPC: H01J49/06 ,  G01N27/62

CPC classification number: H01J49/062 ,  G01N27/622

Abstract: An interface for an ion mobility spectrometry-mass spectrometry (IMS-MS) system includes a first ion guide for receiving ions from an IMS drift cell, and a second ion guide for receiving ions from the first ion guide, and positioned in a chamber separate from the first ion guide. Electrodes of the second ion guide subject the ions to an axial DC electric field while the second ion guide is held at a lower pressure than the first ion guide. In some embodiments, the first ion guide may be an ion funnel and the second ion guide may be a linear multipole device.

Abstract translation: 用于离子迁移光谱 - 质谱（IMS-MS）系统的界面包括用于接收来自IMS漂移单元的离子的第一离子引导件和用于接收来自第一离子导向器的离子的第二离子引导件， 从第一离子导向器。 第二离子导向器的电极将离子导向轴向DC电场，而第二离子导向器保持在比第一离子导向器更低的压力下。 在一些实施例中，第一离子导向器可以是离子漏斗，并且第二离子导向器可以是线性多极装置。

公开(公告)号：US20150219598A1

公开(公告)日：2015-08-06

申请号：US14170068

申请日：2014-01-31

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Ruwan T. Kurulugama ,  Christian Klein ,  John Fjeldsted

IPC: G01N27/62 ,  H01J49/00

CPC classification number: G01N27/622 ,  H01J49/0009 ,  H01J49/0031

Abstract: The collision cross section (CCS) of a sample ion may be calculated by measuring a total drift time taken by the sample ion to travel through an ion mobility spectrometry drift cell to an ion detector. The CCS may be calculated based on the total drift time measured, and on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility dominated region between the drift cell and the detector. The proportionality coefficient may be determined from measuring the total drift times of reference ions. Calculation of the CCS of the sample ion may also be based on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility-independent region where the velocity of the ion depends on the electrostatic field strength, mass and the charge state of the ion.

Abstract translation: 样品离子的碰撞横截面（CCS）可以通过测量样品离子通过离子迁移光谱漂移池移动到离子检测器所需的总漂移时间来计算。 CCS可以基于所测量的总漂移时间以及定义由样品离子穿过漂移池和检测器之间的迁移率控制区域所花费的时间的比例系数来计算。 可以通过测量参考离子的总漂移时间来确定比例系数。 样品离子的CCS的计算也可以基于比例系数，其定义了样品离子行进通过不依赖于迁移率的区域所花费的时间，其中离子的速度取决于静电场强度，质量和电荷 离子的状态。

公开(公告)号：US20140353483A1

公开(公告)日：2014-12-04

申请号：US13906023

申请日：2013-05-30

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Mark H. Werlich ,  Ruwan T. Kurulugama ,  Thomas A. Knotts

IPC: H01J49/06 ,  H01J49/26

CPC classification number: H01J49/062 ,  G01N27/622 ,  H01J49/26

Abstract: An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage differential may be controlled to avoid voltage breakdown in a low-pressure, high-voltage gas environment. The ion optics device may in some cases be an ion mobility drift cell.

Abstract translation: 离子处理装置包括串联定位并围绕轴线包围体积的导电真空歧管段。 这些段彼此电隔离并且可被电压源独立地寻址。 离子光学器件位于体积中。 每个歧管段和离子光学器件之间的电压差通过向相应的歧管段施加不同的电压而保持在最大值之下。 可以控制电压差以避免在低压，高压气体环境中的电压击穿。 在一些情况下，离子光学器件可能是离子迁移率漂移单元。

公开(公告)号：US08637816B1

公开(公告)日：2014-01-28

申请号：US13827685

申请日：2013-03-14

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Kenneth R. Newton

IPC: H01J3/00 ,  H01J49/42 ,  H01J49/26 ,  B01D59/44

CPC classification number: H01J49/02 ,  H01J49/004 ,  H01J49/40 ,  H01J49/429

Abstract: A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be analyzed without significant ion loss or undue time expenditure. The collision cell may provide a large ion acceptance aperture and relatively smaller ion emission aperture. The collision cell may pulse ions out to the mass analyzer. The mass analyzer may be a time-of-flight analyzer. The timing of pulsing of ions out from the collision cell may be matched with the timing of pulsing of ions into the time-of-flight analyzer.

Abstract translation: 通过在离子阱中积聚母体离子获得质谱，将所选择的m / z比的母体离子喷射到碰撞池中，从母体离子产生碎片离子，并分析质量分析器中的碎片离子。 其他母体离子保留在离子阱中，因此可以通过从离子阱中大量选择性地扫描母体离子来重复该过程。 以这种方式，可以分析母体离子的全质量范围或完全质量范围的任何所需子集，而没有显着的离子损失或不适当的时间支出。 碰撞池可以提供大的离子接受孔和相对较小的离子发射孔。 碰撞单元可以将离子脉冲输出到质量分析器。 质量分析仪可以是飞行时间分析仪。 从碰撞池中脉冲离子的时间可以与离子脉冲到飞行时间分析仪的时间相匹配。

公开(公告)号：US09482642B2

公开(公告)日：2016-11-01

申请号：US14170068

申请日：2014-01-31

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Ruwan T. Kurulugama ,  Christian Klein ,  John Fjeldsted

IPC: H01J49/00 ,  G01N27/62

CPC classification number: G01N27/622 ,  H01J49/0009 ,  H01J49/0031

Abstract: The collision cross section (CCS) of a sample ion may be calculated by measuring a total drift time taken by the sample ion to travel through an ion mobility spectrometry drift cell to an ion detector. The CCS may be calculated based on the total drift time measured, and on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility dominated region between the drift cell and the detector. The proportionality coefficient may be determined from measuring the total drift times of reference ions. Calculation of the CCS of the sample ion may also be based on a proportionality coefficient that defines the time taken by the sample ion to travel through a mobility-independent region where the velocity of the ion depends on the electrostatic field strength, mass and the charge state of the ion.

Abstract translation: 样品离子的碰撞横截面（CCS）可以通过测量样品离子通过离子迁移光谱漂移池移动到离子检测器所需的总漂移时间来计算。 CCS可以基于所测量的总漂移时间以及定义由样品离子穿过漂移池和检测器之间的迁移率控制区域所花费的时间的比例系数来计算。 可以通过测量参考离子的总漂移时间来确定比例系数。 样品离子的CCS的计算也可以基于比例系数，其定义了样品离子行进通过不依赖于迁移率的区域所花费的时间，其中离子的速度取决于静电场强度，质量和电荷 离子的状态。

公开(公告)号：US08653446B1

公开(公告)日：2014-02-18

申请号：US13731573

申请日：2012-12-31

Applicant: Agilent Technologies, Inc.

Inventor： Alexander Mordehai ,  Edward Darland

IPC: H01J49/40

CPC classification number: H01J49/40 ,  G01N27/622

Abstract: A method is provided increasing the useful dynamic range of an ion mobility spectrometry (IMS) or an IMS-mass spectrometry (IMS-MS) device. The method includes accumulating a first sample of ions over a first time interval; providing the first sample of ions to an ion detector to provide a first frame, accumulating a second sample of ions over a second time interval, where the second time interval is different than the first time interval, and providing the second sample of ions to the ion detector to provide a second frame. First data points of the first frame are selectively combined with second data points of the second frame to provide an accumulation frame of the first and second samples of ions.

Abstract translation: 提供增加离子迁移谱（IMS）或IMS质谱（IMS-MS）装置的有用动态范围的方法。 该方法包括在第一时间间隔内累积第一离子样品; 将第一离子样品提供给离子检测器以提供第一框架，在第二时间间隔内累积离子的第二样品，其中第二时间间隔不同于第一时间间隔，并且将第二离子样品提供给 离子检测器提供第二帧。 第一帧的第一数据点与第二帧的第二数据点选择性地组合，以提供离子的第一和第二样本的累积帧。