公开(公告)号：US09462810B2

公开(公告)日：2016-10-11

申请号：US14108502

申请日：2013-12-17

Applicant: AJINOMOTO CO., INC.

Inventor： Hajime Koyama ,  Tsutomu Arakawa ,  Daisuke Ejima

IPC: C12N7/06 ,  C12N7/00 ,  A61K39/21 ,  A01N47/44 ,  C12N7/04 ,  A23L3/3508 ,  A61K31/198 ,  A61K39/00

CPC classification number: A01N47/44 ,  A23L3/3508 ,  A23V2002/00 ,  A61K31/198 ,  A61K2039/5252 ,  C12N7/00 ,  C12N7/04 ,  C12N7/06 ,  C12N2710/16663 ,  C12N2760/16163 ,  C12N2760/18863 ,  A23V2200/10 ,  A23V2250/0606

Abstract: The present invention provides a method for conveniently producing a protein formulation in which viruses are inactivated, without impairing the quality of the obtained protein formulation, characterized by including the step of exposing the protein formulation contaminated with the viruses to a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5. The present invention also provides a virus inactivation method characterized by including the step of contacting a virus-containing object with a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5.

Abstract translation: 本发明提供了一种方便地制备其中病毒灭活而不损害所获得的蛋白质制剂的质量的蛋白质制剂的方法，其特征在于包括将被病毒污染的蛋白质制剂暴露于0.1-2M的 精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5.本发明还提供了一种病毒灭活方法，其特征在于包括使病毒含有物体与0.1-2M水溶液接触的步骤 的精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5。

公开(公告)号：US20140107207A1

公开(公告)日：2014-04-17

申请号：US14108502

申请日：2013-12-17

Applicant: AJINOMOTO CO., INC.

Inventor： Hajime Koyama ,  Tsutomu Arakawa ,  Daisuke Ejima

IPC: A01N47/44 ,  A61K31/198

CPC classification number: A01N47/44 ,  A23L3/3508 ,  A23V2002/00 ,  A61K31/198 ,  A61K2039/5252 ,  C12N7/00 ,  C12N7/04 ,  C12N7/06 ,  C12N2710/16663 ,  C12N2760/16163 ,  C12N2760/18863 ,  A23V2200/10 ,  A23V2250/0606

Abstract: The present invention provides a method for conveniently producing a protein formulation in which viruses are inactivated, without impairing the quality of the obtained protein formulation, characterized by including the step of exposing the protein formulation contaminated with the viruses to a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5. The present invention also provides a virus inactivation method characterized by including the step of contacting a virus-containing object with a 0.1-2M aqueous solution of arginine, an arginine derivative, or a mixture thereof, the aqueous solution being adjusted to pH 3.5 to 5.

Abstract translation: 本发明提供了一种方便地制备其中病毒灭活而不损害所获得的蛋白质制剂的质量的蛋白质制剂的方法，其特征在于包括将被病毒污染的蛋白质制剂暴露于0.1-2M的 精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5.本发明还提供了一种病毒灭活方法，其特征在于包括使病毒含有物体与0.1-2M水溶液接触的步骤 的精氨酸，精氨酸衍生物或其混合物，将该水溶液调节至pH 3.5至5。