公开(公告)号：US20140094489A1

公开(公告)日：2014-04-03

申请号：US14098774

申请日：2013-12-06

Applicant: AJINOMOTO CO., INC.

Inventor： Tamotsu SUZUKI ,  Takahiro KOSHIBA ,  Munetaka TOKUMASU ,  Koji OHSUMI

IPC: C07D495/04 ,  C07D333/38 ,  C07D409/06 ,  C07D417/06 ,  C07D405/06 ,  C07D307/68

CPC classification number: C07D495/04 ,  A61K38/00 ,  C07D307/68 ,  C07D333/38 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

Abstract: The present invention provides a blood glucose elevation inhibitor having a serine protease inhibitory action, which is a novel therapeutic or prophylactic agent for obesity. A compound represented by the following formula (I) wherein each symbol is as described in the specification, or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供具有丝氨酸蛋白酶抑制作用的血糖升高抑制剂，其是用于肥胖症的新型治疗或预防剂。 由下式（I）表示的化合物或其药学上可接受的盐，其中每个符号如说明书中所述。

公开(公告)号：US20150313889A1

公开(公告)日：2015-11-05

申请号：US14799130

申请日：2015-07-14

Applicant: AJINOMOTO CO., INC.

Inventor： Atsushi KONISHI ,  Munetaka TOKUMASU ,  Tamotsu SUZUKI ,  Takahiro KOSHIBA ,  Koji OHSUMI ,  Osamu IKEHARA ,  Yuko KODAMA

IPC: A61K31/4535 ,  A61K31/4525 ,  A61K31/381 ,  A61K31/426 ,  A61K31/341 ,  A61K31/4025

CPC classification number: A61K31/4535 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/426 ,  A61K31/4525 ,  C07C53/18 ,  C07D277/20 ,  C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D405/06 ,  C07F9/3808 ,  C07F9/65515

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

公开(公告)号：US20150099733A1

公开(公告)日：2015-04-09

申请号：US14567506

申请日：2014-12-11

Applicant: AJINOMOTO CO., INC.

Inventor： Takahiro KOSHIBA ,  Munetaka TOKUMASU ,  Taisuke ICHIMARU ,  Koji OHSUMI ,  Tadakiyo NAKAGAWA ,  Tatsuhiro YAMADA ,  Kayo MATSUMOTO ,  Tamotsu SUZUKI

IPC: C07D333/40 ,  C07D409/12 ,  C07D409/06

CPC classification number: A61K31/381 ,  A61K31/19 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/4725 ,  A61K38/05 ,  C07D319/12 ,  C07D333/38 ,  C07D333/40 ,  C07D409/06 ,  C07D409/12

Abstract: Compounds represented by the following formula (I); wherein each symbol is as defined in the specification, are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract translation: 由下式（I）表示的化合物; 其中每个符号如说明书中所定义，可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。

公开(公告)号：US20170101372A1

公开(公告)日：2017-04-13

申请号：US15389639

申请日：2016-12-23

Applicant: AJINOMOTO CO., INC.

Inventor： Yoshiro KITAHARA ,  Koji OHSUMI ,  Seiji KITAJIMA ,  Shimpei OGAWA

IPC: C07C335/20 ,  C07C335/16

CPC classification number: A61K31/17 ,  A61K31/277 ,  C07C335/16 ,  C07C335/20

Abstract: Sweetness receptor antagonists represented by formula (I): wherein each symbol is described herein, are useful for the prophylaxis or treatment of metabolic syndrome, diabetes, obesity and the like.

公开(公告)号：US20190022039A1

公开(公告)日：2019-01-24

申请号：US16144314

申请日：2018-09-27

Applicant: AJINOMOTO CO., INC.

Inventor： Tomohiro FUJII ,  Koji OHSUMI ,  Seiji KITAJIMA ,  Yoshiro KITAHARA

IPC: A61K31/18 ,  C07C311/21 ,  C07C321/14 ,  C07D209/20 ,  C07D295/135 ,  C07D333/20 ,  C07D307/52 ,  C07D271/06 ,  C07C311/13 ,  C07D249/12 ,  C07D213/56 ,  A61P3/04 ,  A61P3/10 ,  A61K31/405 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/381 ,  A61K31/341 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/4406 ,  A61K45/06

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the present specification, or a salt thereof are useful for the prophylaxis or treatment of diabetes and obesity, and diseases related thereto.

公开(公告)号：US20150011511A1

公开(公告)日：2015-01-08

申请号：US14496363

申请日：2014-09-25

Applicant: AJINOMOTO CO., INC.

Inventor： Atsushi KONISHI ,  Munetaka TOKUMASU ,  Tamotsu SUZUKI ,  Takahiro KOSHIBA ,  Koji OHSUMI ,  OSAMU IKEHARA ,  Yuko KODAMA

IPC: C07D307/68 ,  C07D405/06 ,  C07F9/38 ,  C07C53/18

CPC classification number: A61K31/4535 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/426 ,  A61K31/4525 ,  C07C53/18 ,  C07D277/20 ,  C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D405/06 ,  C07F9/3808 ,  C07F9/65515

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract translation: 由式（I）表示的化合物：其中每个符号如说明书中所定义，及其药学上可接受的盐可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。