公开(公告)号：US20180334693A1

公开(公告)日：2018-11-22

申请号：US15982623

申请日：2018-05-17

Applicant: AJINOMOTO CO., INC.

Inventor： Christine Roche ,  Benjamin Mijts ,  Peter Kelly ,  Matthew Davis ,  Sayaka Asari ,  Keita Fukui ,  Miku Toyazaki

IPC: C12P7/42 ,  C12P13/12 ,  C12R1/15 ,  C12R1/19 ,  C12N15/77 ,  C12N9/10 ,  C12N9/78 ,  C12N9/88

CPC classification number: C12P7/42 ,  C12N9/1003 ,  C12N9/78 ,  C12N9/88 ,  C12N15/77 ,  C12P7/22 ,  C12P7/24 ,  C12P13/12 ,  C12R1/15 ,  C12R1/19 ,  C12Y201/02003 ,  C12Y305/0401 ,  C12Y403/01017

Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.

公开(公告)号：US10858676B2

公开(公告)日：2020-12-08

申请号：US15982623

申请日：2018-05-17

Applicant: AJINOMOTO CO., INC.

Inventor： Christine Roche ,  Benjamin Mijts ,  Peter Kelly ,  Matthew Davis ,  Sayaka Asari ,  Keita Fukui ,  Miku Toyazaki

IPC: C12P7/42 ,  C12P13/12 ,  C12R1/15 ,  C12R1/19 ,  C12N15/77 ,  C12N9/78 ,  C12N9/88 ,  C12N9/10 ,  C12P7/22 ,  C12P7/24

Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.