公开(公告)号：US20220334105A1

公开(公告)日：2022-10-20

申请号：US17604010

申请日：2019-11-26

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hyun Chul YOON ,  Ka Ram KIM ,  Hyeong Jin CHUN ,  Jae Ho KIM

IPC: G01N33/53 ,  G01N15/14 ,  G01N33/58

Abstract: A bio-substance analysis method using a sensing substrate having a fluid channel is disclosed. The method includes mixing retroreflective particles with a detection solution containing a target bio-substance, wherein a first bio-recognition substance selectively reacting with the target bio-substance is modified on the retroreflective particles; placing the sensing substrate so that a bottom is located under a cover in a direction of gravity; injecting the detection solution containing therein the retroreflective particles into a fluid channel and maintaining the solution in the channel for a first time duration; turning the sensing substrate upside down so that the bottom is located above the cover in the direction of gravity and maintaining the sensing substrate in the turned state for a second time duration; irradiating light into the fluid channel through the bottom; and generating and analyzing an image based on light retroreflected from the retroreflective particles.

公开(公告)号：US20240255410A1

公开(公告)日：2024-08-01

申请号：US18007348

申请日：2021-07-28

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hyun Chul YOON ,  Jae-Ho KIM ,  Ka Ram KIM

IPC: G01N15/1434 ,  G01N21/51 ,  G01N33/483

CPC classification number: G01N15/1434 ,  G01N21/51 ,  G01N33/4833

Abstract: The present invention provides a cell measurement device and method in which retroreflective particles are introduced to measure cells, and thus, an optical signal is obtained without fixing of life activity of cells and performing a separate staining process. An example of the use of retroreflection-based cytometry is evaluation of cell migration. The cells capture the retroreflective particles during cell migration or growth, and migrate in a state that the particles are captured in the cell or bind to the cells. The migrated cells are observed in a form of bright dots inside the cells under irradiation of white light as a non-spectroscopic light source to the cells in the retroreflective optical system. The number of bright spots is counted, and thus, the number of cells and the presence thereof thus can be easily measured based on an image.

公开(公告)号：US20240125698A1

公开(公告)日：2024-04-18

申请号：US18276320

申请日：2022-02-10

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hyun Chul YOON ,  Ka Ram KIM ,  Kyung Wom LEE ,  Jae-ho KIM

IPC: G01N21/55 ,  G01N33/487

CPC classification number: G01N21/55 ,  G01N33/487 ,  G01N2021/177 ,  G01N2021/551

Abstract: A gadget for retroreflected signal measurement is disclosed. The gadget for measuring the retroreflected signal includes a partitioning wall; a portable terminal receiving portion disposed on one surface of the partitioning wall; a biosensor receiving portion disposed on the other surface of the partitioning wall and constructed to receive a biosensor therein; a light exit channel defined in the partitioning wall and at one side thereof; and a light-receiving channel adjacent to the light exit channel and defined in the partitioning wall, wherein light passes through the light exit channel and then is reflected from the biosensor, and then is incident into the light-receiving channel.

公开(公告)号：US20160109370A1

公开(公告)日：2016-04-21

申请号：US14645009

申请日：2015-03-11

Applicant: LG ELECTRONICS INC. ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yunhee KU ,  Moosub KIM ,  Yongju YANG ,  Seung Yeon SONG ,  Kang Sun LEE ,  Hyun Chul YOON ,  Yong Duk HAN ,  Yoo Min PARK

IPC: G01N21/76 ,  G03F7/20

CPC classification number: G03F7/2002 ,  G01N21/78 ,  G01N2400/00 ,  G03F7/027

Abstract: The present disclosure relates to a sensor for detecting saccharide and manufacturing method thereof and detection method of glycated hemoglobin using the same wherein the sensor for detecting saccharide includes a reactive layer synthesized with hydrogel having a boronic acid-modified 3D mesh structure. A selective and sensitive detection of the glycated protein including glucose or glycated hemoglobin (HbA1c) in blood through high level of signal may be enabled, and the durability of the sensor for detecting saccharide may be enhanced.

Abstract translation: 本发明涉及用于检测糖类的传感器及其制造方法以及使用该传感器的糖化血红蛋白的检测方法，其中用于检测糖的传感器包括与具有硼酸改性的3D网状结构的水凝胶合成的反应层。 可以通过高水平的信号选择性和灵敏地检测血液中的葡萄糖或糖化血红蛋白（HbA1c），并且可以增强用于检测糖的传感器的耐久性。