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公开(公告)号：US20240151714A1
公开(公告)日：2024-05-09
申请号：US18281460
申请日：2022-03-14
发明人： Tae Hyeon YOO , Hyeon Ji PARK
IPC分类号： G01N33/53 , G01N33/573 , G01N33/68 , G01N33/74 , G01N33/76
CPC分类号： G01N33/5308 , G01N33/573 , G01N33/6887 , G01N33/74 , G01N33/76 , G01N2333/4712 , G01N2333/59 , G01N2333/71 , G01N2333/96463
摘要： The present invention relates to a target analyte detection composition based on a proximity proteolysis reaction and a target analyte detection method using same. More specifically, the present invention relates to a method for detecting a target analyte, the method comprising a step in which when a first binder and a second binder bind to the target analyte, hybridization is made between ssDNA linked to the first binder and ssDNA linked to a protease and between ssDNA linked to the second binder and ssDNA linked to a zymogen, whereby a signal generated by a proximity proteolysis reaction between the protease and the zymogen is detected.
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公开(公告)号：US20210348219A1
公开(公告)日：2021-11-11
申请号：US17282650
申请日：2019-10-02
发明人： Tae Hyeon YOO , Hyeon Ji PARK
IPC分类号： C12Q1/6834 , G01N33/53 , C12Q1/6818 , G01N21/64 , G01N21/31
摘要： A method for detecting a target nucleic acid includes: (a) a step of mixing a sample containing the target nucleic acid with a nucleic acid detection solution containing i) ssDNA-protease conjugate, ii) ssDNA-zymogen conjugate, and iii) a substrate specific for the zymogen; and (b) a step of detecting a signal generated by a proximity proteolysis reaction between the ssDNA-zymogen conjugate and the ssDNA-protease conjugate which are hybridized to the target nucleic acid.
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公开(公告)号：US20180148487A1
公开(公告)日：2018-05-31
申请号：US15578094
申请日：2015-07-31
发明人： Sang Dun CHOI , Tae Hyeon YOO , Seol Hee PARK
CPC分类号： C07K14/4703 , A61K38/00 , A61P29/00 , A61P37/00 , C07K7/08 , C07K14/47 , C07K16/2896
摘要： The present disclosure relates to a peptide for inhibiting a TLR4 signaling pathway, a TLR4 antagonist including the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. More specifically, the present disclosure relates to a peptide which binds to a TLR4/MD2 composite to inhibit the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs, a TLR4 antagonist including the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. The peptide according to the present disclosure has an excellent effect of inhibiting the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs by inhibiting a TLR4 signaling pathway induced by a liphopolysaccharide (LPS), and thus can be favorably used as a composition for preventing or treating autoimmune diseases and inflammatory diseases occurring by the TLR4 signaling pathway.
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