公开(公告)号：US20240132497A1

公开(公告)日：2024-04-25

申请号：US18524807

申请日：2023-11-30

Applicant: Alcon Inc.

Inventor： David Ellis ,  Howard Allen Ketelson

IPC: C07D471/08 ,  A61K9/00 ,  A61P27/10 ,  C07D243/38 ,  C07D471/04

CPC classification number: C07D471/08 ,  A61K9/0048 ,  A61P27/10 ,  C07D243/38 ,  C07D471/04

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

公开(公告)号：US20230285289A1

公开(公告)日：2023-09-14

申请号：US18319794

申请日：2023-05-18

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  David L. Meadows

IPC: A61K9/107 ,  A61K9/00 ,  C09K23/00 ,  C09K23/14

CPC classification number: A61K9/107 ,  A61K9/0048 ,  C09K23/00 ,  C09K23/14 ,  C09K23/017

Abstract: The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.

公开(公告)号：US20230201031A1

公开(公告)日：2023-06-29

申请号：US18145437

申请日：2022-12-22

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  Rekha Rangarajan

IPC: A61F9/007 ,  A61F2/14 ,  A61F9/00 ,  A61L17/10 ,  A61L31/14

CPC classification number: A61F9/007 ,  A61F2/142 ,  A61F9/0017 ,  A61L17/10 ,  A61L31/148

Abstract: A dissolvable medical device for placing on the outer exposed surface of the eye to heal the corneal wound comprising of: a polymeric film has sufficient dimensions to substantially cover a cornea when applied to an eye, wherein the polymeric film comprising one or more mucoadhesive polymers, wherein the polymeric film dissolves between 15 minutes to 120 minutes to release the mucoadhesive polymers, wherein the dissolved polymeric film is not impeding visualization of ocular tissue while maintaining a protective film on outer surface of the eye.

公开(公告)号：US12102559B2

公开(公告)日：2024-10-01

申请号：US16864894

申请日：2020-05-01

Applicant: ALCON INC.

Inventor： Howard Allen Ketelson ,  Rekha Rangarajan ,  Walter R Laredo ,  Stephen John Collins

IPC: A61F9/00 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/36

CPC classification number: A61F9/0017 ,  A61K9/0051 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/36 ,  A61K2121/00

Abstract: Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more polymers as well as a softener/plasticizer so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. Increased retention time on the ocular surface for longer lasting relief may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.

公开(公告)号：US20240307355A1

公开(公告)日：2024-09-19

申请号：US18604926

申请日：2024-03-14

Applicant: ALCON INC.

Inventor： Rekha Rangarajan ,  Howard Allen Ketelson ,  Randall Renato Kolega ,  Mark Joseph Bridle ,  Alexei Grigoryevich Merzlikine

IPC: A61K31/4168 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/38 ,  A61P27/02

CPC classification number: A61K31/4168 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/186 ,  A61K47/38 ,  A61P27/02

Abstract: The present disclosure is directed to pharmaceutical compositions comprising apraclonidine and a polymer, wherein the apraclonidine is present at greater than 0.05% (w/v) to no more than 0.2% (w/v) based on the total volume of the pharmaceutical composition, methods of preparing the same and methods for reducing ocular redness by administering the same.

公开(公告)号：US11690802B2

公开(公告)日：2023-07-04

申请号：US17200043

申请日：2021-03-12

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  David L. Meadows

IPC: A61K9/107 ,  A61K9/00 ,  B01F17/00 ,  C09K23/00 ,  C09K23/14

CPC classification number: A61K9/107 ,  A61K9/0048 ,  C09K23/00 ,  C09K23/017 ,  C09K23/14

Abstract: The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.

公开(公告)号：US20220323346A1

公开(公告)日：2022-10-13

申请号：US17808342

申请日：2022-06-23

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  Rekha Rangarajan

IPC: A61K9/00 ,  A61K31/357 ,  A61K31/498 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36

Abstract: Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more mucoadhesive polymers polymers, a biodegradable polymer as well as softener/plasticizer so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. The biodegradable polymer containing eye insert may increase dissolution time on the ocular surface for longer lasting relief, may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.

公开(公告)号：US11376275B2

公开(公告)日：2022-07-05

申请号：US17060343

申请日：2020-10-01

Applicant: Alcon Inc.

Inventor： James W. Davis ,  Howard Allen Ketelson ,  Elaine E. Campbell ,  David L. Meadows ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/32 ,  A61K31/728

Abstract: The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the to compositions also comprise a borate compound.

公开(公告)号：US11779537B2

公开(公告)日：2023-10-10

申请号：US17808342

申请日：2022-06-23

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  Rekha Rangarajan

IPC: A61K9/00 ,  A61K31/357 ,  A61K31/498 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36

CPC classification number: A61K9/0051 ,  A61K31/357 ,  A61K31/498 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36

Abstract: Polymeric eye inserts are provided that may be dissolvable when placed in the cul-de-sac of the eye. These inserts may contain one or more mucoadhesive polymers, a biodegradable polymer as well as softener/plasticizer so that, when inserted into the eye, they may absorb tears, and dissolve and slowly release lubricant into the tear film to lubricate and protect the ocular surface for an extended duration of time. The biodegradable polymer containing eye insert may increase dissolution time on the ocular surface for longer lasting relief, may reduce dosing frequency and patient burden typically associated with topical drop usage. These polymeric eye inserts also may include one or more pharmaceutically active agents.

公开(公告)号：US11730699B2

公开(公告)日：2023-08-22

申请号：US17147007

申请日：2021-01-12

Applicant: Alcon Inc.

Inventor： Howard Allen Ketelson ,  James W. Davis ,  Rekha Rangarajan

IPC: A61K31/736 ,  A61P27/02 ,  A61K9/00 ,  A61K9/107 ,  A61K47/14 ,  A61K47/24 ,  B01F17/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  B82Y5/00

CPC classification number: A61K9/1075 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  B82Y5/00

Abstract: The present invention is directed to a lipid-based ophthalmic emulsion. The emulsion has an increased amount of a mucoadhesive galactomannan polymer that promotes a long-lasting protection against desiccation and moisture retention.