公开(公告)号：US12059508B2

公开(公告)日：2024-08-13

申请号：US16416654

申请日：2019-05-20

申请人： ALLOSOURCE

发明人： Aidan Griffin ,  Timothy Bennett ,  Joslynn Shamis ,  Luke Shubin ,  Yurid Gourgel ,  Lauren Blume ,  Kenneth Blood ,  Adrian Samaniego ,  Bruce Mock ,  Cathleen Lucine Badillo ,  Matthew Peterson ,  Reginald Stilwell

IPC分类号： B01F27/808 ,  A61L27/36 ,  B01F27/115 ,  B01F35/71

CPC分类号： A61L27/3691 ,  A61L27/3608 ,  B01F27/115 ,  B01F27/808 ,  B01F35/714 ,  A61L27/3687 ,  A61L2300/414 ,  A61L2430/34 ,  A61L2430/40

摘要： Systems and methods for the automated demineralization of bone and decellularization of soft tissue include a mixing assembly communicatively coupled with a control and reporting system. The mixing assembly includes a housing that supports a cannister sub-assembly forming a mixing chamber having a reagent inlet, a reagent outlet, and an internal fluid agitator. A motor is operably coupled with the agitator and configured to spin the agitator in first and second directions relative to the cannister, thereby agitating fluid contained within the mixing chamber. At least one pump is configured to progressively inject measured quantities of a plurality of reagents into the mixing chamber. The associated control and reporting system includes a user terminal that displays a graphical user interface enabling a user to initiate an automated demineralization or decellularization procedure in which the mixing assembly demineralizes tissue placed within the mixing chamber. Other embodiments are also disclosed.