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    COMPUTER SURROGATE MODEL TO PREDICT THE SINGLE-PHASE MIXING QUALITY IN STEADY STATE MIXING TANKS
    3.
    发明公开
    COMPUTER SURROGATE MODEL TO PREDICT THE SINGLE-PHASE MIXING QUALITY IN STEADY STATE MIXING TANKS 审中-公开

    公开(公告)号：US20240005147A1

    公开(公告)日：2024-01-04

    申请号：US18038041

    申请日：2021-09-29

    申请人： AMGEN INC.

    发明人： Emad Ghadirian Hoseinabadi ,  William Leigh Johnson

    IPC分类号： G06N3/08 ,  B01F35/22 ,  B01F27/808 ,  B01F35/00 ,  G06F30/28

    CPC分类号： G06N3/08 ,  B01F35/2206 ,  B01F27/808 ,  B01F35/55 ,  G06F30/28 ,  B01F2215/0404

    摘要： Systems and methods of using a surrogate machine learning model, based on a CFD model, to predict the mixing quality in steady state mixing tanks are provided. An exemplary method includes generating a plurality of training CFD models for a plurality of training steady state mixing configurations based on a plurality of steady state mixing factors associated with each training steady state mixing configuration; calculating a mixing quality for each training steady state mixing configuration using each respective training CFD model; generating a training dataset that includes the steady state mixing factors associated with each training steady state mixing configuration, and the calculated mixing quality for each training steady state mixing configuration; and training a machine learning model, using the training dataset, to predict mixing qualities for steady state mixing configurations based on based on steady state mixing factors associated with the steady state mixing configurations.

    Mixing apparatus and method for operating a mixing apparatus
    4.
    发明授权
    Mixing apparatus and method for operating a mixing apparatus 有权

    公开(公告)号：US11794154B2

    公开(公告)日：2023-10-24

    申请号：US16785789

    申请日：2020-02-10

    申请人： SARTORIUS STEDIM BIOTECH GMBH

    发明人： Stefan Zeuch ,  Markus Haeusser ,  Stefan Weisshaar ,  Jens Ludwig

    IPC分类号： B01F27/09 ,  B01F27/808 ,  B01F27/90 ,  B01F35/513 ,  B01F35/30

    CPC分类号： B01F27/808 ,  B01F27/90 ,  B01F35/513 ,  B01F2035/3513

    摘要： A mixing apparatus (1) for mixing a fluid and/or solid. The mixing apparatus includes a mixing container (100) having an interior in which the fluid and/or solid can be arranged. A feed-through passage (10) extends through a container wall (101) of the mixing container. A drive shaft (50) is fed through the feed-through passage, to drive a stirring element (30) arranged at least partly in the interior of the mixing container. The stirring element is used to mix the fluid and/or solid arranged in the mixing container. A drive-side shaft end (51) of the drive shaft couples the drive shaft to a drive (120) arranged outside of the mixing container. An adjustable seal (70) seals off the feed-through passage. A setting apparatus (80) is provided to switch the adjustable seal into at least two sealing operation states having different sealing effects.