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    Tissue Extracts and Related Methods
    2.
    发明公开
    Tissue Extracts and Related Methods 审中-公开

    公开(公告)号：US20240263141A1

    公开(公告)日：2024-08-08

    申请号：US18567470

    申请日：2022-06-08

    申请人： ALLOSOURCE

    发明人： William Maslanik ,  Reginald Stilwell ,  Jeffrey Brown ,  Michael Floren

    IPC分类号： C12N5/0775 ,  A61K35/28 ,  C12M1/00 ,  C12M1/42

    CPC分类号： C12N5/0662 ,  A61K35/28 ,  C12M35/04 ,  C12M47/04 ,  C12N2501/10 ,  C12N2510/04

    摘要： Provided are enriched tissue extracts and methods of making and using such extracts. The enriched tissue extracts contain biologically active components. Some extracts produced by the methods contain extracellular vesicles. The methods can involve administering a physical stress on a biological sample comprising live cells or otherwise stimulating the live cells of the biological sample. Also contemplated are methods in which the biological sample does not contain live cells. The biological sample is incubated in an extraction solution for a period of time sufficient for extraction of biologically active components from the biological sample. Methods of using the extracts, or extracellular vesicles isolated therefrom, therapeutically and for in vitro purposes are also provided.

    CARTILAGE MOSAIC COMPOSITIONS AND METHODS
    4.
    发明申请
    CARTILAGE MOSAIC COMPOSITIONS AND METHODS 有权

    公开(公告)号：US20210353422A1

    公开(公告)日：2021-11-18

    申请号：US17388388

    申请日：2021-07-29

    申请人： AlloSource

    发明人： Carolyn Barrett Rorick ,  Yaling Shi

    IPC分类号： A61F2/30 ,  A61L27/36

    摘要： Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.

    Osseous-sanding accessory system
    5.
    发明授权
    Osseous-sanding accessory system 有权

    公开(公告)号：US10730122B2

    公开(公告)日：2020-08-04

    申请号：US15838879

    申请日：2017-12-12

    申请人： Allosource

    发明人： Denis M. Meade ,  Shane Graham

    IPC分类号： B24B45/00 ,  B23D45/00 ,  B24B27/06 ,  B24B23/02 ,  B24B19/00 ,  B23D55/00 ,  A61F2/46 ,  A61B17/14 ,  B23D45/06

    摘要： There are disclosed systems and methods for safely and effectively removing the articular cartilage and cortical bone layers from an articular surface of a human cadaveric femoral head. One embodiment includes an osseous-sanding accessory system installed upon a conventional band saw having a motor and a cabinet that houses a pulley coupled with a primary drive shaft rotated by the motor. The accessory system may include a threaded drive shaft coupled with the primary drive shaft, a grinding disk having an abrasive surface and affixed about a distal end of the threaded drive shaft, and a removable accessory table mounted to the band saw below the grinding disk. When the motor rotates the primary drive shaft, and thus the threaded drive shaft, the grinding disk rotates relative to the accessory table and abrades osseous tissues introduced to the abrasive surface of the grinding disk. Other embodiments are also disclosed.

    High-pressure water debridement system
    6.
    发明授权
    High-pressure water debridement system 有权

    公开(公告)号：US10661312B2

    公开(公告)日：2020-05-26

    申请号：US15815075

    申请日：2017-11-16

    申请人： Allosource

    发明人： Denis M. Meade ,  Shane Graham ,  Kyle von Kaenel

    IPC分类号： B08B3/02 ,  A61F2/46 ,  A61B90/70 ,  A61L2/00

    摘要： There is disclosed a system and methods for debriding soft tissue from bone using a high-pressure water debridement system. One embodiment includes a cylindrical sleeve bounded by endcaps and having a drainage port positioned for effluent drainage. A central shaft is configured to receive a bone segment and is disposed along a longitudinal center of the sleeve and rotatively coupled between the endcaps. At least one high-pressure water nozzle is disposed on each side of the sleeve, each of which is positioned to impact the bone segment with a high-pressure water stream. A rotational actuator is configured to rotate the central shaft and the bone segment relative to the sleeve and the water nozzles such that when the high-pressure water nozzles are operational, the high-pressure water streams debride the bone segment. Other embodiments are also disclosed.

    STERILE WATER DISPERSION SYSTEM FOR ALLOGRAFT PREPARATION AND PROCESSING
    7.
    发明申请
    STERILE WATER DISPERSION SYSTEM FOR ALLOGRAFT PREPARATION AND PROCESSING 审中-公开

    公开(公告)号：US20190388245A1

    公开(公告)日：2019-12-26

    申请号：US16564742

    申请日：2019-09-09

    申请人： Allosource

    发明人： Donald Von Kaenel ,  Daniel R. Hanten, II

    IPC分类号： A61F2/46

    摘要： There is disclosed a system and method for dispersing sterile water from a circulating high-purity water system to a processing field containing allograft tissue. One embodiment includes a fluid inlet that is fluidly coupled with and configured to receive sterile water from the water system. The dispersion system also includes at least first and second fluid outlets that are selectively operable to deliver respective first and second fluid streams into different areas of the processing field. At least one of the first and second fluid outlets may be associated with a regulator valve configured to provide an adjustable flowrate to conserve water pulled from the circulating water system to meet the needs of the application taking place within the processing field. Other embodiments are also disclosed.

    Trochlea-angle measurement template
    8.
    发明授权
    Trochlea-angle measurement template 有权

    公开(公告)号：US10052046B2

    公开(公告)日：2018-08-21

    申请号：US14944457

    申请日：2015-11-18

    申请人： ALLOSOURCE

    发明人： Brittany Nickolas ,  Christopher Mast ,  Todd Huft ,  Meghan Gabriel

    IPC分类号： A61B5/00 ,  A61B5/107 ,  A61F2/46 ,  A61B90/00 ,  A61F2/38

    CPC分类号： A61B5/1071 ,  A61B2090/067 ,  A61F2/3877 ,  A61F2/4657 ,  A61F2002/4668

    摘要： The disclosure provides apparatus and methods of use pertaining to a measurement template for use in allograft preparation and processing. Specifically, the template may be used to measure the trochlea angle of the trochlea groove of the distal human femur. The measurement template may be formed of a flat metal plate having first and second ends, each forming a different angle designed to fit against the trochlea groove and provide an indication of the angle of the groove in relation to the angles formed by the template. The trochlea angle of the allograft may then be documented, allowing for proper matching between allograft tissue and transplant recipient physiology. The measurement template may be adapted for a variety of configurations depending on desired and/or common allograft requirements. Other embodiments are also disclosed.

    BONE-CUTTING JIG SYSTEM
    9.
    发明申请
    BONE-CUTTING JIG SYSTEM 审中-公开

    公开(公告)号：US20180221174A1

    公开(公告)日：2018-08-09

    申请号：US15826324

    申请日：2017-11-29

    申请人： Allosource

    发明人： Denis M. Meade ,  Shane Graham ,  Kyle von Kaenel

    IPC分类号： A61F2/46 ,  A61B17/15

    摘要： There is disclosed a system and methods for safely, precisely, and efficiently cutting cadaveric bone segments into a number of dimensionally standardized pieces. One embodiment provides a jig system for use with a band saw. The jig system may include a v-shaped trough riding upon a plate and at least one rail designed to glide within a corresponding groove formed in the band saw table and stretching parallel to the blade. The trough may include a channel having a series of incremental stops extending between its proximal and distal ends. A bone-advancement wedge may be advanced proximally along the channel between the incremental stops to advance at least one bone segment within the trough toward the proximal end of the trough such that, by sliding the rail(s) within the table groove(s), a desired incremental portion of the bone segment is introduced to the blade. Other embodiments are also disclosed.