公开(公告)号：US09688759B2

公开(公告)日：2017-06-27

申请号：US14866105

申请日：2015-09-25

Applicant: AMGEN INC.

Inventor： Tara Arvedson ,  Gregory Dyas ,  James B. Rottman ,  Barbra Sasu ,  Xiao-juan Bi ,  Grace Ki Jeong Lee ,  Jackie Z. Sheng

IPC: C07K16/28 ,  G01N33/68 ,  G01N33/90 ,  A61K38/18 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K38/1816 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/76 ,  G01N33/6872 ,  G01N33/90 ,  G01N2800/00

Abstract: Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.

公开(公告)号：US20140286953A1

公开(公告)日：2014-09-25

申请号：US14103351

申请日：2013-12-11

Applicant: Amgen Inc.

Inventor： Barbra Sasu ,  Mitsuru Haniu ,  Thomas Charles Boone ,  Xiao-juan Bi ,  Grace Ki Jeong Lee ,  Tara Arvedson ,  Aaron George Winters ,  Keegan Cooke ,  Jackie Z. Sheng

IPC: C07K16/26 ,  A61K38/18 ,  G01N33/74 ,  A61K39/395

CPC classification number: C07K16/26 ,  A61K38/1816 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/575 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C12N15/1136 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  G01N33/74 ,  A61K2300/00

Abstract: The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related disorders.

Abstract translation: 本发明涉及纯化的，正确折叠的铁调素，结合铁调素的抗体，以及制备和使用这些材料的方法。 还提供了治疗的铁调素相关病症的方法。