-
公开(公告)号：US11834683B2
公开(公告)日：2023-12-05
申请号：US17387896
申请日：2021-07-28
Applicant: Amgen Inc.
Inventor： Huiren Zhao , Grace Ki Jeong Lee , Thomas Wolfe , Cherylene Plewa , Jackie Z. Sheng
CPC classification number: C12N7/00 , C12N15/86 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152
Abstract: The present invention is directed to an in vitro method of producing a recombinant AAV virion in a mammalian host cell that comprises a functional adenoviral E1A gene (e.g., a HEK 293T cell) and rAAV virions made by the method.
-
公开(公告)号：US10336798B2
公开(公告)日：2019-07-02
申请号：US15625891
申请日：2017-06-16
Applicant: Amgen Inc.
Inventor： Yumei Xiong , Yi Zhang , Jackie Z. Sheng , Agnes Eva Hamburger , Murielle M. Veniant-Ellison , Grant Shimamoto , Xiaoshan Min , Zhulun Wang , Jie Tang , Gunasekaran Kannan , Kenneth W. Walker , Bryan Lemon
IPC: A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , C07K14/475 , C07K14/495 , C07K14/51 , A61K39/00
Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
-
公开(公告)号：US11739131B2
公开(公告)日：2023-08-29
申请号：US16416050
申请日：2019-05-17
Applicant: Amgen Inc.
Inventor： Yumei Xiong , Yi Zhang , Jackie Z. Sheng , Agnes Eva Hamburger , Murielle M. Veniant-Ellison , Grant Shimamoto , Xiaoshan Min , Zhulun Wang , Jie Tang , Gunasekaran Kannan , Kenneth W. Walker , Bryan Lemon
IPC: C07K14/475 , C07K14/495 , C07K14/51 , A61K38/16 , A61K38/00 , A61K38/18 , A61K38/17 , A61K39/00
CPC classification number: C07K14/475 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K39/0005 , C07K14/495 , C07K14/51 , A61K2039/6056 , C07K2319/30
Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
-
Patent Agency Ranking
公开(公告)号：US10894814B2
公开(公告)日：2021-01-19
申请号：US15826442
申请日：2017-11-29
Applicant: Amgen Inc.
Inventor： Yumei Xiong , Yi Zhang , Jackie Z. Sheng , Agnes Eva Hamburger , Murielle M. Veniant-Ellison , Grant Shimamoto , Xiaoshan Min , Zhulun Wang , Jie Tang , Gunasekaran Kannan , Marissa Mock , Kenneth William Walker
IPC: C07K14/475
Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
-
公开(公告)号：US11078464B2
公开(公告)日：2021-08-03
申请号：US14915630
申请日：2014-08-28
Applicant: AMGEN INC.
Inventor： Huiren Zhao , Grace Ki Jeong Lee , Thomas Wolfe , Cherylene Plewa , Jackie Z. Sheng
Abstract: The present invention is directed to an in vitro method of producing a recombinant AAV virion in a mammalian host cell that comprises a functional adenoviral E1A gene and rAAV virions made by the method. Host cells are transfected with varying ratios of plasmids comprising the E1A gene and virions.
-
公开(公告)号：US09862752B2
公开(公告)日：2018-01-09
申请号：US14908459
申请日：2014-07-31
Applicant: Amgen Inc.
Inventor： Yumei Xiong , Yi Zhang , Jackie Z. Sheng , Agnes Eva Hamburger , Murielle Veniant-Ellison , Grant Shimamoto , Xiaoshan Min , Zhulun Wang , Jie Tang , Gunasekaran Kannan , Marissa Mock , Kenneth Walker
IPC: C07K14/00 , C07K14/475
CPC classification number: C07K14/475 , C07K2319/30
Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
-
公开(公告)号：US09688759B2
公开(公告)日：2017-06-27
申请号：US14866105
申请日：2015-09-25
Applicant: AMGEN INC.
Inventor： Tara Arvedson , Gregory Dyas , James B. Rottman , Barbra Sasu , Xiao-juan Bi , Grace Ki Jeong Lee , Jackie Z. Sheng
CPC classification number: C07K16/28 , A61K38/1816 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/76 , G01N33/6872 , G01N33/90 , G01N2800/00
Abstract: Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.
-
8.发明申请HEPCIDIN, HEPCIDIN ANTAGONISTS AND METHODS OF USE 审中-公开HEPCIDIN，HEPCIDIN ANTAGONISTS AND METHODS OF USE公开(公告)号：US20140286953A1
公开(公告)日：2014-09-25
申请号：US14103351
申请日：2013-12-11
Applicant: Amgen Inc.
Inventor： Barbra Sasu , Mitsuru Haniu , Thomas Charles Boone , Xiao-juan Bi , Grace Ki Jeong Lee , Tara Arvedson , Aaron George Winters , Keegan Cooke , Jackie Z. Sheng
IPC: C07K16/26 , A61K38/18 , G01N33/74 , A61K39/395
CPC classification number: C07K16/26 , A61K38/1816 , A61K39/3955 , A61K2039/505 , C07K14/575 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12N15/1136 , C12N2310/111 , C12N2310/14 , C12N2310/53 , G01N33/74 , A61K2300/00
Abstract: The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related disorders.
Abstract translation: 本发明涉及纯化的，正确折叠的铁调素，结合铁调素的抗体，以及制备和使用这些材料的方法。 还提供了治疗的铁调素相关病症的方法。
-
-
-
-
-
-
-
Search Results
8
records
(took 0.027 seconds)
