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公开(公告)号：US20240050430A1
公开(公告)日：2024-02-15
申请号：US18213464
申请日：2023-06-23
Applicant: Amgen Inc.
Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
CPC classification number: A61K31/517 , A61P35/00 , C07D471/04 , A61K39/39558 , C07D403/04 , A61K31/4985
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20240287068A1
公开(公告)日：2024-08-29
申请号：US18640641
申请日：2024-04-19
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61K31/519 , A61K31/7068 , A61K38/07 , A61P35/00
CPC classification number: C07D471/04 , A61K31/519 , A61P35/00 , A61K31/7068 , A61K38/07 , A61K2300/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20220175782A1
公开(公告)日：2022-06-09
申请号：US17579359
申请日：2022-01-19
Applicant: AMGEN INC.
Inventor： John Gordon ALLEN , Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Jennifer Rebecca ALLEN , Margaret CHU-MOYER , Albert AMEGADZIE , Ning CHEN , Clifford GOODMAN , Jonathan D. LOW , Vu Van MA , Ana Elena MINATTI , Nobuko NISHIMURA , Alexander J. PICKRELL , Hui-Ling WANG , Youngsook SHIN , Aaron C. SIEGMUND , Kevin C. YANG , Nuria A. TAMAYO , Mary WALTON , Qiufen XUE
IPC: A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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Patent Agency Ranking
公开(公告)号：US20220213101A1
公开(公告)日：2022-07-07
申请号：US17692026
申请日：2022-03-10
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20210171529A1
公开(公告)日：2021-06-10
申请号：US17103350
申请日：2020-11-24
Applicant: Amgen Inc.
Inventor： Jennifer R. ALLEN , Albert AMEGADZIE , Matthew P. BOURBEAU , Ning CHEN , Clifford GOODMAN , Giulia LATTANZI , Iain LINGARD , Qingyian LIU , Jonathan D. LOW , Vu Van MA , Ana E. MINATTI , Alfonso POZZAN , Corey REEVES , Aaron C. SIEGMUND , Sabrina TASSINI , Federica TONELLI , Mary WALTON
IPC: C07D487/04 , A61P3/04 , C07D471/04 , C07D498/04
Abstract: The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D”). The compounds have a general Formula 1: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
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公开(公告)号：US20220395504A1
公开(公告)日：2022-12-15
申请号：US17363878
申请日：2021-06-30
Applicant: Amgen Inc.
Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20200207766A1
公开(公告)日：2020-07-02
申请号：US16817109
申请日：2020-03-12
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are methods of using KRAS G12C inhibitors. These methods of using the inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20190077801A1
公开(公告)日：2019-03-14
申请号：US16125359
申请日：2018-09-07
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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