公开(公告)号：US11813426B2

公开(公告)日：2023-11-14

申请号：US16753711

申请日：2018-10-01

Applicant: AMGEN INC.

Inventor： Ronald Forster ,  Gregory Gordon ,  Martin Hering ,  Matthew Wayne Janke ,  Andrew N. King ,  Wael Mismar

IPC: A61M5/142 ,  A61M5/145 ,  A61M5/315 ,  A61M5/158

CPC classification number: A61M5/14248 ,  A61M5/1456 ,  A61M5/31571 ,  A61M2005/14256 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2005/3154 ,  A61M2205/583

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.

公开(公告)号：US20190143047A1

公开(公告)日：2019-05-16

申请号：US16154759

申请日：2018-10-09

Applicant: AMGEN INC.

Inventor： Julian Jazayeri ,  Ronald Forster ,  Jolita Seckute ,  Olivia Alice Henderson ,  Kristen Brown ,  Gregory Gordon ,  Rasmus Øhlenschlæger ,  Peter Dan Kaare Soelberg

IPC: A61M5/315 ,  A61M5/20

Abstract: A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.

公开(公告)号：US11191904B2

公开(公告)日：2021-12-07

申请号：US16154759

申请日：2018-10-09

Applicant: AMGEN INC.

Inventor： Julian Jazayeri ,  Ronald Forster ,  Jolita Seckute ,  Olivia Alice Henderson ,  Kristen Brown ,  Gregory Gordon ,  Rasmus Øhlenschlæger ,  Peter Dan Kaare Soelberg

IPC: A61M5/31 ,  A61M5/315 ,  F16J1/00 ,  A61M5/142 ,  A61M5/20

Abstract: A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.

公开(公告)号：US20200254172A1

公开(公告)日：2020-08-13

申请号：US16753711

申请日：2018-10-01

Applicant: AMGEN INC.

Inventor： Ronald Forster ,  Gregory Gordon ,  Martin Hering ,  Matthew Wayne Janke ,  Andrew N. King ,  Wael Mismar

IPC: A61M5/145 ,  A61M5/315 ,  A61M5/142

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing, a container, a trigger member, and an interlock assembly. The trigger member may be selectively moveable relative to the housing to activate operation of at least one activatable element of the drug delivery device. The interlock assembly may include a lever mounted rotatably relative to the housing, a proximity sensor moveable between a first position extending beyond an exterior surface of the housing and a second position retracted toward the housing, and a rotational biasing member operably connected to the proximity sensor via the lever. When the proximity sensor is in the first position, the interlock assembly may limit movement of the trigger member relative to the housing. The rotational biasing member may be configured to exert a torque biasing the proximity sensor toward the first sensor position.