公开(公告)号：US11660435B2

公开(公告)日：2023-05-30

申请号：US17642345

申请日：2020-10-05

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Scott R. Gibson ,  Heejin Lee

IPC: A61M31/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/20

CPC classification number: A61M31/00 ,  A61M5/1407 ,  A61M5/14248 ,  A61M5/2053 ,  A61M5/2066

Abstract: The devices, assemblies, and methods described herein utilize photoacoustic principals to create a jet of fluid using a ultrasonic resonance member and a pulsed laser light beam. The ultrasonic resonance member is a treated substrate having an liquid interface surface in contact with a fluid. When a pulsed laser light beam is applied to the treated substrate, pressure is generated via induced ultrasonic waves to urge the fluid into a jet stream.

公开(公告)号：US20240066206A1

公开(公告)日：2024-02-29

申请号：US17767475

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Heejin Lee ,  Daniel Eduardo Groszmann ,  Sheldon B. Moberg ,  Mohammad Bonakdar ,  Rasmus Ohlenschlaeger

IPC: A61M5/142

CPC classification number: A61M5/142 ,  A61M2205/123 ,  A61M2205/3368 ,  A61M2205/3633 ,  A61M2205/584 ,  A61M2205/585 ,  A61M2207/00

Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle assembly, and a temperature indicator. The housing defines an inner volume and includes at least one opening. The container contains a medicament which is urged out of the container by the activation mechanism. The needle assembly has a needle and/or a cannula to deliver the medicament from the container. The temperature indicator is operably coupled with the outer surface of the container and is responsive to a change in temperature of the container.

公开(公告)号：US20230173198A1

公开(公告)日：2023-06-08

申请号：US17911545

申请日：2021-02-08

Applicant: AMGEN INC.

Inventor： Mohammad Bonakdar ,  Daniel Eduardo Groszmann ,  Heejin Lee ,  Leonela Sabrina Vega Loaisa

IPC: A61M5/46 ,  A61M5/32

CPC classification number: A61M5/46 ,  A61M5/3293 ,  A61M5/322 ,  A61M2205/3306 ,  A61M2205/50

Abstract: Drug delivery member insertion depth sensing assemblies, drug delivery devices, and methods for determining an insertion depth of a drug delivery member are disclosed. The sensing assemblies can include electrical sensing assemblies with direct or indirect measurement components or optical sensing assemblies with one or more light sources and one or more photodiodes. A controller of the sensing assemblies can receive data associated with the drug delivery member in an insertion position. The data can then be correlated to an insertion depth of the drug delivery member.

公开(公告)号：US20220265975A1

公开(公告)日：2022-08-25

申请号：US17642345

申请日：2020-10-05

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Scott R. Gibson ,  Heejin Lee

IPC: A61M31/00 ,  A61M5/20 ,  A61M5/142 ,  A61M5/14

Abstract: The devices, assemblies, and methods described herein utilize photoacoustic principals to create a jet of fluid using a ultrasonic resonance member and a pulsed laser light beam. The ultrasonic resonance member is a treated substrate having an liquid interface surface in contact with a fluid. When a pulsed laser light beam is applied to the treated substrate, pressure is generated via induced ultrasonic waves to urge the fluid into a jet stream.

公开(公告)号：US20210346601A1

公开(公告)日：2021-11-11

申请号：US17264139

申请日：2019-09-23

Applicant: AMGEN INC.

Inventor： Heejin Lee ,  Scott Robert Gibson ,  Mehran Mojarrad ,  Jeffrey Schacherl

IPC: A61M5/172 ,  A61M5/14 ,  A61M5/168

Abstract: Systems and methods for interventional dosing based on sensed feedback are disclosed. A system may include one or more reservoirs filled or fillable with, respectively, one or more drug products, an administration member, a fluid delivery system, one or more sensors, and optionally a controller. The administration member may be insertable into a patient and connected or connectable in fluid communication with the one or more reservoirs. The fluid delivery system may be operable to deliver the one or more drug products from the one or more reservoirs to the patient via the administration member. The one or more sensors may be operable to sense one or more biological conditions of the patient, including, but not limited to, a cytokine level and/or a biomarker indicative of cytokine release syndrome. The controller may be configured to control operation of the fluid delivery system based on output from the one or more sensors.