公开(公告)号：US20180030116A1

公开(公告)日：2018-02-01

申请号：US15547730

申请日：2015-08-26

Applicant: AMGEN INC.

Inventor： Jason C. O'Neill ,  Randal R. Ketchem ,  Taeweon Lee ,  Vishnu Chintalgattu ,  Jennitte Leann Stevens

IPC: C07K14/81

CPC classification number: C07K14/8146 ,  A61K38/00

Abstract: The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.

公开(公告)号：US11149078B2

公开(公告)日：2021-10-19

申请号：US15547730

申请日：2015-08-26

Applicant: AMGEN INC.

Inventor： Jason C. O'Neill ,  Randal R. Ketchem ,  Taeweon Lee ,  Vishnu Chintalgattu ,  Jennitte Leann Stevens

IPC: C07K14/81 ,  A61K38/00

Abstract: The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.

公开(公告)号：US20180305465A1

公开(公告)日：2018-10-25

申请号：US15779325

申请日：2016-11-23

Applicant: AMGEN INC. ,  XENCOR, INC.

Inventor： Jennitte Leann Stevens ,  Mercedesz Balazs ,  Olivier Nolan-Stevaux ,  Gregory Moore ,  John Desjarlais ,  Matthew J. Bernett ,  Seung Y. Chu ,  Rumana Rashid ,  Umesh Muchhal

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/40 ,  A61P35/00

CPC classification number: C07K16/468 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.