公开(公告)号：US20200249248A1

公开(公告)日：2020-08-06

申请号：US16741808

申请日：2020-01-14

Applicant: AMGEN INC.

Inventor： Brandon Zachary Sarich ,  Michael R. Berke ,  Chuck Z. Li ,  Thomas Clark Pearson

IPC: G01N35/00 ,  G01N35/10

Abstract: Methods and systems of performing an assay. A system for performing an assay includes an enclosure defining a temperature-controlled space. An imaging system, an actuator and a dispenser are disposed within the space. The actuator receives a well plate having wells. The actuator is to move the well plate relative to the imaging system to enable the imaging system to obtain image data of one of the wells. The dispenser includes a pump, an outlet and a reservoir holder to receive a reservoir containing a compound. The pump is to be fluidly coupled to the reservoir and an outlet. The pump is to pump the compound from the reservoir through the outlet into one of the wells. The system also includes a controller. The controller is to cause the dispenser to dispense the compound into the first one of the wells while the imaging system obtains the image data.

公开(公告)号：US11733251B2

公开(公告)日：2023-08-22

申请号：US16741808

申请日：2020-01-14

Applicant: AMGEN INC.

Inventor： Brandon Zachary Sarich ,  Michael R. Berke ,  Chuck Z. Li ,  Thomas Clark Pearson

IPC: G01N35/00 ,  G01N35/10

CPC classification number: G01N35/00029 ,  G01N35/00693 ,  G01N35/1002 ,  G01N2035/00306 ,  G01N2035/00346 ,  G01N2035/1027

Abstract: Methods and systems of performing an assay. A system for performing an assay includes an enclosure defining a temperature-controlled space. An imaging system, an actuator and a dispenser are disposed within the space. The actuator receives a well plate having wells. The actuator is to move the well plate relative to the imaging system to enable the imaging system to obtain image data of one of the wells. The dispenser includes a pump, an outlet and a reservoir holder to receive a reservoir containing a compound. The pump is to be fluidly coupled to the reservoir and an outlet. The pump is to pump the compound from the reservoir through the outlet into one of the wells. The system also includes a controller. The controller is to cause the dispenser to dispense the compound into the first one of the wells while the imaging system obtains the image data.

公开(公告)号：US20220137061A1

公开(公告)日：2022-05-05

申请号：US17431075

申请日：2020-02-14

Applicant: AMGEN INC.

Inventor： Chao-Hsiang Wu ,  Gang Xue ,  Brandon Zachary Sarich ,  Michael R. Berke ,  Jacob Sebastain ,  Pik Chan

IPC: G01N33/68 ,  G01N30/08 ,  G01N30/20 ,  G01N30/84 ,  G01N30/72 ,  G01N30/88 ,  G01N30/30 ,  C07K1/20

Abstract: Systems and methods that facilitate the automatic (or substantially automatic) preparation of a sample of a product containing molecules for analysis and automatic (or substantially automatic) performance of an assay of that sample. Thus, the preparation and analysis can be performed substantially in-real time, or, in other words, much more quickly than presently allowed by conventional systems and methods.