公开(公告)号：US11427627B2

公开(公告)日：2022-08-30

申请号：US14916993

申请日：2014-09-05

Applicant: AMGEN INC.

Inventor： Zhimei Du ,  Pranhitha Reddy ,  Randal B. Bass ,  Feng He ,  William C. Fanslow, III ,  Yuling Zhang ,  Da Ren ,  Randal R. Ketchem

IPC: C07K1/00 ,  C07K16/00 ,  A61K39/395 ,  A61K39/40

Abstract: The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation.

公开(公告)号：US10465009B2

公开(公告)日：2019-11-05

申请号：US14649469

申请日：2013-12-05

Applicant: Amgen Inc.

Inventor： Richard J. Armitage ,  Michelle Blake ,  William C. Fanslow, III ,  Jason Charles O'Neill ,  Gunasekaran Kannan ,  Jiangchun Xu ,  Mark Edward Tometsko ,  Zhulun Wang ,  Athena Sudom

IPC: C07K16/28 ,  A61K47/48 ,  A61K45/06 ,  A61N5/10 ,  A61K47/68 ,  A61K39/00

Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates and uses thereof.

公开(公告)号：US10220090B2

公开(公告)日：2019-03-05

申请号：US14967167

申请日：2015-12-11

Applicant: Amgen Inc.

Inventor： Richard J. Armitage ,  Michelle Blake ,  William C. Fanslow, III ,  Jason Charles O'Neill ,  Gunasekaran Kannan ,  Jiangchun Xu ,  Mark Edward Tometsko

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  A61K31/395 ,  A61K47/68

Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.

公开(公告)号：US09574008B2

公开(公告)日：2017-02-21

申请号：US14618945

申请日：2015-02-10

Applicant: AMGEN INC.

Inventor： John M. Delaney ,  William C. Fanslow, III ,  Chadwick T. King

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/28 ,  A61K47/48 ,  A61K31/5365 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K31/5365 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present invention relates to CD27L antigen binding proteins, such an antibodies, polynucleotides encoding said CD27l antigen binding proteins, antibody drug conjugate compositions, and methods for diagnosing and treating diseases associated with CD27L expression.

Abstract translation: 本发明涉及CD27L抗原结合蛋白，如抗体，编码所述CD271抗原结合蛋白的多核苷酸，抗体药物共轭组合物，以及用于诊断和治疗与CD27L表达相关疾病的方法。

公开(公告)号：US09243058B2

公开(公告)日：2016-01-26

申请号：US14098275

申请日：2013-12-05

Applicant: Amgen Inc.

Inventor： Richard J. Armitage ,  Michelle Blake ,  William C. Fanslow, III ,  Jason Charles O'Neill ,  Gunasekaran Kannan ,  Jiangchun Xu ,  Mark Edward Tometsko

IPC: C07K16/18 ,  A61K45/06 ,  A61K47/48 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K31/395 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6867 ,  A61K2039/505 ,  A61K2039/572 ,  C07K16/18 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.

Abstract translation: 本发明涉及BCMA（B细胞成熟抗原）抗原结合蛋白，例如抗体，编码所述抗原结合蛋白的多核苷酸序列，以及用于诊断和治疗疾病的组合物和方法。 本发明还涉及BCMA抗体药物偶联物。