公开(公告)号：US20250000786A1

公开(公告)日：2025-01-02

申请号：US18757797

申请日：2024-06-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sunyoung PARK ,  Si Young CHO ,  Kyeonghwan HWANG ,  Daejin MIN

IPC: A61K8/9789 ,  A61Q19/08

Abstract: Disclosed herein is a method for senotherapy; prevention, improvement or treatment of aging-related disease; improvement of skin elasticity or wrinkles; improvement of skin barrier; or improvement of skin pigmentation, containing administering an effective amount of tea tree (Camellia Sinensis) root extract to a subject in need thereof. In one aspect, a senotherapy composition containing the tea tree (Camellia Sinensis) root extract has an excellent senolytic effect to selectively remove senescent cells and an excellent senomorphic effect to inhibit the production of senescence associated secretory phenotype (SASP) of senescent cells.

公开(公告)号：US20250017840A1

公开(公告)日：2025-01-16

申请号：US18731949

申请日：2024-06-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyuk KIM ,  Sunyoung PARK ,  Si Young CHO ,  Sang Hyun MOH ,  Jeong Hun LEE ,  Hyo Hyun SEO ,  Hye In KIM

IPC: A61K8/64 ,  A23L33/18 ,  A61Q19/08 ,  C07K14/00

Abstract: A novel senotherapy peptide and a method for senotherapy are disclosed. The method for sentherapy includes administering an effective amount thereof to a subject in need thereof. The novel senotherapy peptide suppresses the interaction between p53 and FOXO4 in the nucleus due to a better binding force with p53 than FOXO4, thereby allowing p53 to be released out of the nucleus and move to mitochondria to induce apoptosis of senescent cells and selectively induce the apoptosis of senescent cells in the skin cells.