公开(公告)号：US20220378676A1

公开(公告)日：2022-12-01

申请号：US17744529

申请日：2022-05-13

Applicant: AMOREPACIFIC CORPORATION ,  KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hyunjung CHOI ,  Dong-Hyung CHO ,  Ji-Eun BAE ,  Joonbum KIM ,  Ji Yeon CHOI ,  Daejin MIN ,  Hye Won NA ,  Hyoung June KIM ,  Wonseok PARK

IPC: A61K8/362 ,  A61K8/02 ,  A61Q19/08 ,  A23L29/00

Abstract: Disclosed herein is a composition for enhancing skin elasticity or improving skin wrinkles. In one aspect, 2-isopropylmalic acid or a salt, hydrate or solvate thereof, which is an active ingredient of the present disclosure, activates skin primary cilia and inhibits the expression of MMP-1 to enhance skin elasticity and improve skin wrinkles. In addition, in one aspect, 2-isopropylmalic acid or a salt, hydrate or solvate thereof, which is an active ingredient of the present disclosure, is a safe material and has the advantage that it can be treated in the living body in various forms such as cosmetics and food.

公开(公告)号：US20250000786A1

公开(公告)日：2025-01-02

申请号：US18757797

申请日：2024-06-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sunyoung PARK ,  Si Young CHO ,  Kyeonghwan HWANG ,  Daejin MIN

IPC: A61K8/9789 ,  A61Q19/08

Abstract: Disclosed herein is a method for senotherapy; prevention, improvement or treatment of aging-related disease; improvement of skin elasticity or wrinkles; improvement of skin barrier; or improvement of skin pigmentation, containing administering an effective amount of tea tree (Camellia Sinensis) root extract to a subject in need thereof. In one aspect, a senotherapy composition containing the tea tree (Camellia Sinensis) root extract has an excellent senolytic effect to selectively remove senescent cells and an excellent senomorphic effect to inhibit the production of senescence associated secretory phenotype (SASP) of senescent cells.

公开(公告)号：US20190004034A1

公开(公告)日：2019-01-03

申请号：US16023045

申请日：2018-06-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sunghoon LEE ,  Il-Hong BAE ,  Daejin MIN ,  Soojung OH ,  Tae Ryong LEE ,  Eungyung CHO

IPC: G01N33/50 ,  C12N5/071

Abstract: According to an embodiment, a method of producing artificial skin includes mixing fibroblasts and collagen to form a dermis simulating layer, applying keratinocytes on the dermis simulating layer and culturing the same, culturing the dermis simulating layer in a first medium that is a keratinocyte medium, and culturing the dermis simulating layer that is cultured in the first medium in a second medium including a DMEM medium and a F12 medium.