公开(公告)号：US20230381114A1

公开(公告)日：2023-11-30

申请号：US18201559

申请日：2023-05-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyuk KIM ,  Chaeyeon Song ,  Joonho Choi

IPC: A61K9/51 ,  A61K31/728 ,  A61K8/02

CPC classification number: A61K9/5192 ,  A61K31/728 ,  A61K8/0241 ,  A61K2800/413

Abstract: The present disclosure relates to a method for preparing hyaluronic acid nanoparticle and to hyaluronic acid nanoparticle prepared by the method. In one aspect of the present disclosure, the method for preparing hyaluronic acid nanoparticle can minimize the size of the hyaluronic acid nanoparticle, and the hyaluronic acid nanoparticle prepared by the method has low viscosity characteristics and is excellent in spreadability, and can penetrate the stratum corneum evenly when applied to the skin.

公开(公告)号：US20230218500A1

公开(公告)日：2023-07-13

申请号：US18149718

申请日：2023-01-04

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoseok AN ,  Hyuk KIM ,  Seunghan PARK ,  Sungyeon CHO

IPC: A61K8/73 ,  A61K8/06 ,  A61Q19/00

CPC classification number: A61K8/735 ,  A61K8/062 ,  A61Q19/007 ,  A61K2800/95 ,  A61K2800/412

Abstract: The disclosure describes an oil-in-water composition for skin external application using a gel of crosslinked hyaluronic acid or a salt thereof and having a sherbet-like texture and feeling of use. The composition of the disclosure comprises the gel particles of crosslinked hyaluronic acid or a salt thereof and emulsion particle having a specific particle size distribution of D(0.5) in an aqueous phase and an oil phase, respectively, so that the composition has a particulate feeling such as sherbet, mashed potato or meringue while having a fluffy appearance or texture, and also provides a refreshing feeling of use when applied, and is easy to clean by comprising the aqueous phase as an outer phase.

公开(公告)号：US20250017840A1

公开(公告)日：2025-01-16

申请号：US18731949

申请日：2024-06-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyuk KIM ,  Sunyoung PARK ,  Si Young CHO ,  Sang Hyun MOH ,  Jeong Hun LEE ,  Hyo Hyun SEO ,  Hye In KIM

IPC: A61K8/64 ,  A23L33/18 ,  A61Q19/08 ,  C07K14/00

Abstract: A novel senotherapy peptide and a method for senotherapy are disclosed. The method for sentherapy includes administering an effective amount thereof to a subject in need thereof. The novel senotherapy peptide suppresses the interaction between p53 and FOXO4 in the nucleus due to a better binding force with p53 than FOXO4, thereby allowing p53 to be released out of the nucleus and move to mitochondria to induce apoptosis of senescent cells and selectively induce the apoptosis of senescent cells in the skin cells.

公开(公告)号：US20220241168A1

公开(公告)日：2022-08-04

申请号：US17589202

申请日：2022-01-31

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyung Su KIM ,  Si Young CHO ,  Young Gyu KANG ,  Hyuk KIM ,  Euidong SON

IPC: A61K8/42 ,  A61Q7/00 ,  A61Q19/04 ,  A61Q19/00 ,  A23L33/00 ,  A23L33/10

Abstract: A composition includes, as an active ingredient, a substance capable of providing a useful effect to the skin by stimulating production of beta (β)-endorphin. The composition containing, as an active ingredient, sanshool, an isomer thereof, a hydrate thereof, or a solvate thereof stimulates production of β-endorphin when applied into the body, thereby providing useful effects to the skin, such as relieving skin irritation from the outside and providing a skin soothing effect.