公开(公告)号：US20210038673A1

公开(公告)日：2021-02-11

申请号：US16766158

申请日：2018-11-22

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yeongran LEE ,  Hyoung-June KIM ,  Jun Seong PARK ,  Kyeonghwan HWANG

IPC: A61K36/82 ,  A61K31/704 ,  A61K8/60 ,  A61K8/9789 ,  A61Q19/08 ,  A23L33/105

Abstract: The present specification discloses a composition for external application to skin, containing a tea plant root extract as an active ingredient, for treatment of skin damage caused by fine dust, whereby the expression level of one or more selected from a group consisting of IL-36G (NM_019618), S100A7 (NM_002963), S100A8 (NM_002964) and XDH (NM_000379), which are genes in skin cells the expression level of which is affected by fine dust, is regulated to a normal level.

公开(公告)号：US20220000742A1

公开(公告)日：2022-01-06

申请号：US17289105

申请日：2019-11-06

Applicant: AMOREPACIFIC CORPORATION ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Eun Mi KIM ,  Kyeonghwan HWANG ,  Dong Hyun KIM ,  Byung-Gee KIM ,  Jinkyung CHOI

IPC: A61K8/49 ,  A61Q19/08 ,  A61Q19/02

Abstract: A composition contains, as an effective component, theasinensin A, an enantiomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition has an excellent stability and provides wrinkle-reducing or skin elasticity-enhancing benefits, and skin-brightening benefits by containing theasinensin A, an enantiomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, as an effective component.

公开(公告)号：US20180256488A1

公开(公告)日：2018-09-13

申请号：US15760882

申请日：2016-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Eun-Jeong CHOI ,  Yonghee LEE ,  Seung Hyun SHIN ,  Kyeonghwan HWANG ,  Eun-Gyung CHO ,  Tae Ryong LEE

IPC: A61K8/9789 ,  A61Q7/00

CPC classification number: A61K8/9789 ,  A61K8/14 ,  A61K36/258 ,  A61Q7/00

Abstract: Disclosed in the present specification are: a composition for preventing hair loss or promoting hair growth, containing ginseng-derived exosome-like vesicles; and a method for preparing the composition. The ginseng-derived exosome-like vesicles can have a diameter of 20-500 nm and can be isolated from ginseng root. The composition contains ginseng-derived exosome-like vesicles as active ingredients, thereby having an effect of inducing hair growth by activating dermal papilla cells (DPCs).

公开(公告)号：US20250000786A1

公开(公告)日：2025-01-02

申请号：US18757797

申请日：2024-06-28

Applicant: AMOREPACIFIC CORPORATION

Inventor： Sunyoung PARK ,  Si Young CHO ,  Kyeonghwan HWANG ,  Daejin MIN

IPC: A61K8/9789 ,  A61Q19/08

Abstract: Disclosed herein is a method for senotherapy; prevention, improvement or treatment of aging-related disease; improvement of skin elasticity or wrinkles; improvement of skin barrier; or improvement of skin pigmentation, containing administering an effective amount of tea tree (Camellia Sinensis) root extract to a subject in need thereof. In one aspect, a senotherapy composition containing the tea tree (Camellia Sinensis) root extract has an excellent senolytic effect to selectively remove senescent cells and an excellent senomorphic effect to inhibit the production of senescence associated secretory phenotype (SASP) of senescent cells.

公开(公告)号：US20180263871A1

公开(公告)日：2018-09-20

申请号：US15760819

申请日：2016-09-23

Applicant: AMOREPACIFIC CORPORATION

Inventor： Suh-Yeon CHOI ,  Eun-Jeong CHOI ,  Bum-Ho BIN ,  Kyeonghwan HWANG ,  Eun-Gyung CHO ,  Tae Ryong LEE

IPC: A61K8/14 ,  A61Q19/02 ,  A61K8/9789

CPC classification number: A61K8/14 ,  A61K8/9789 ,  A61K36/258 ,  A61K2800/413 ,  A61Q19/02

Abstract: Disclosed are: a lightening composition comprising ginseng-derived exosome-like vesicles; and a method for producing the ginseng-derived exosome-like vesicles. The ginseng-derived exosome-like vesicles may have a diameter of between 20 and 500 nm, and may be isolated from ginseng root. Because the composition comprises the ginseng-derived exosome-like vesicles as an active ingredient, said composition is effective in preventing, improving or treating skin pigmentation conditions such as liver spots, freckles, lentigo, birth marks and melanoma by effectively suppressing the production of melanin.

公开(公告)号：US20200261351A1

公开(公告)日：2020-08-20

申请号：US16651878

申请日：2018-08-23

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June KIM ,  Kyeonghwan HWANG ,  Jun Seong PARK ,  Tae Ryong LEE

IPC: A61K8/9789 ,  A61K36/82 ,  A23L33/105 ,  A61Q19/08

Abstract: The present specification discloses a composition for caring for skin damage caused by fine dust, wherein the composition includes a fermented tea extract as an active ingredient and adjusts the expression level of at least one selected from the following group of genes which are present in skin cells and have expression levels that are affected by fine dust to normal levels, said group consisting of: IL-1B (NM_000576), IL-36G (NM_019618), S100A7 (NM_002963), LCE3D (NM_032563), PTGS2 (NM_000963) and XDH (NM_000379). Damage to skin cells can be cared for by using the composition for caring for skin damage caused by fine dust to return gene expression levels, which change due to fine dust, to normal levels.

公开(公告)号：US20190233868A1

公开(公告)日：2019-08-01

申请号：US16337688

申请日：2017-09-28

Applicant: Amorepacific Corporation ,  Konkuk University Industrial Cooperation Corp

Inventor： Junseong PARK ,  Kyeonghwan HWANG ,  Deok-Kun OH ,  Kyung-Chul SHIN

IPC: C12P33/16 ,  C12N9/42

CPC classification number: C12P33/16 ,  C07J17/00 ,  C12N9/24 ,  C12N9/2445 ,  C12P19/44 ,  C12Y302/01021 ,  C12Y302/01055

Abstract: Disclosed are a composition for production of ginsenoside compound K using a high temperature-β-glycosidase and a high temperature-α-L-arabinofuranosidase, and a method for preparing ginsenoside compound k. The composition for producing ginsenoside compound k and the method for preparing ginsenoside compound k according to one aspect of the present invention allow high temperature-βglycosidase and high temperature-a-L-arabinofuranosidase to exhibit stable activity even at high temperatures, thereby increasing a reaction rate. The composition for producing ginsenoside compound k and the method for preparing ginsenoside compound k according to one aspect of the present invention allow a large quantity of ginsenoside compound k to be produced in a short time, thereby exhibiting an effect of producing a high yield, and thus can be utilized industrially.