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公开(公告)号：US20190218624A1
公开(公告)日：2019-07-18
申请号：US16323103
申请日：2017-08-04
Inventor： Alexander Green , Duo Ma
IPC: C12Q1/6897 , C12Q1/70 , C12Q1/689 , C12Q1/6809 , C12Q1/6816 , C12N15/113
CPC classification number: C12Q1/6897 , C12N15/113 , C12N15/63 , C12N15/67 , C12N2310/531 , C12Q1/68 , C12Q1/6809 , C12Q1/6816 , C12Q1/689 , C12Q1/70
Abstract: Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.
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公开(公告)号：US20240052400A1
公开(公告)日：2024-02-15
申请号：US18453129
申请日：2023-08-21
Inventor： Alexander Green , Duo Ma , Anli Tang
IPC: C12Q1/6825 , C12Q1/6816
CPC classification number: C12Q1/6825 , C12Q1/6816 , Y02A50/30
Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.
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公开(公告)号：US11125743B2
公开(公告)日：2021-09-21
申请号：US16279045
申请日：2019-02-19
Inventor： Alexander Green , Duo Ma , Luhui Shen , Chris Diehnelt
IPC: G01N33/543 , G01N33/53 , G01N33/569 , C07K19/00
Abstract: Provided herein are methods and systems for low-cost, low-equipment detection of pathogens in biological sample. In particular, provided herein is a low-cost method for detecting norovirus that provides reliable, visible test with femtomolar, attomolar, and zeptomolar detection limits and that uses materials suitable for deployment of the methods in the field.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20190285620A1
公开(公告)日：2019-09-19
申请号：US16279045
申请日：2019-02-19
Inventor： Alexander Green , Duo Ma , Luhui Shen , Chris Diehnelt
IPC: G01N33/543 , G01N33/569 , C07K19/00 , G01N33/53
Abstract: Provided herein are methods and systems for low-cost, low-equipment detection of pathogens in biological sample. In particular, provided herein is a low-cost method for detecting norovirus that provides reliable, visible test with femtomolar, attomolar, and zeptomolar detection limits and that uses materials suitable for deployment of the methods in the field.
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公开(公告)号：US20240018608A1
公开(公告)日：2024-01-18
申请号：US18465077
申请日：2023-09-11
Inventor： Alexander Green , Duo Ma
IPC: C12Q1/70 , C12Q1/6816
CPC classification number: C12Q1/701 , C12Q1/6816
Abstract: Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.
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公开(公告)号：US11802318B2
公开(公告)日：2023-10-31
申请号：US16323103
申请日：2017-08-04
Inventor： Alexander Green , Duo Ma
IPC: C12Q1/6897 , C12Q1/70 , C12N15/113 , C12Q1/68 , C12N15/67 , C12N15/63 , C12Q1/6809 , C12Q1/6816 , C12Q1/689
CPC classification number: C12Q1/6897 , C12N15/113 , C12N15/63 , C12N15/67 , C12Q1/68 , C12Q1/6809 , C12Q1/689 , C12Q1/6816 , C12Q1/70 , C12N2310/531
Abstract: Provided herein are synthetic nucleic acid molecules known as loop-mediated riboregulators that have single-nucleotide polymorphism (SNP) sensitivity and ultralow OFF state signal levels. Loop-mediated riboregulators can activate or repress gene expression in response to trigger RNAs bearing completely arbitrary sequences. Also provided herein are methods of using such synthetic nucleic acid molecules for detecting the presence or absence of a particular target RNA in, for example, a biological sample.
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公开(公告)号：US11773430B2
公开(公告)日：2023-10-03
申请号：US16342722
申请日：2017-10-17
Inventor： Alexander Green , Duo Ma , Anli Tang
IPC: C12Q1/6825 , C12Q1/6816
CPC classification number: C12Q1/6825 , C12Q1/6816 , Y02A50/30 , C12Q1/6825 , C12Q2525/205 , C12Q1/6816 , C12Q2525/205 , C12Q2565/625
Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.
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公开(公告)号：US20210396745A1
公开(公告)日：2021-12-23
申请号：US17462842
申请日：2021-08-31
Inventor： Alexander Green , Duo Ma , Luhui Shen , Chris Diehnelt
IPC: G01N33/543 , G01N33/569 , C07K19/00 , G01N33/53
Abstract: Provided herein are methods and systems for low-cost, low-equipment detection of pathogens in biological sample. In particular, provided herein is a low-cost method for detecting norovirus that provides reliable, visible test with femtomolar, attomolar, and zeptomolar detection limits and that uses materials suitable for deployment of the methods in the field.
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