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    TWO-CHAMBER TYPE COMBINED CONTAINER SYRINGE
    1.
    发明申请
    TWO-CHAMBER TYPE COMBINED CONTAINER SYRINGE 有权
    双室式组合式集装箱灌装机

    公开(公告)号：US20140316342A1

    公开(公告)日：2014-10-23

    申请号：US14180353

    申请日：2014-02-13

    Applicant: ARTE CORPORATION

    Inventor： Atsushi KANAZAWA ,  Katsuyoshi Tuchida ,  Junichi Komuro ,  Seiji Shimazaki

    IPC: A61M5/19 ,  A61M5/315

    CPC classification number: A61M5/19 ,  A61M5/284 ,  A61M5/3137 ,  A61M5/31501 ,  A61M2005/3132

    Abstract: A two-chamber type combined container-syringe includes an outer tube (10) formed in a tubular shape having a uniform inner diameter about an axis (O) thereof throughout the axis direction and provided with a bypass groove (11a) concaved from an inner circumferential surface in a portion in the axis direction, wherein the inner diameter of the outer tube (10) is 6.0 mm or more and 10.0 mm or less, the plurality of bypass grooves are formed in the circumferential direction of the axis at intervals, a cross-sectional area of the bypass groove perpendicular to the axis is 0.13% or more and 0.24% or less of an inner circumferential cross-sectional area of the outer tube perpendicular to the axis, and a depth of the bypass groove concaved from the inner circumferential surface is 2.7% or more and 3.8% or less of the inner diameter of the outer tube. As a result, solution can smoothly flow through the bypass groove, and an amount of solution remaining in the bypass groove can be reduced.

    Abstract translation: 双室型组合容器注射器包括形成为管状的外管（10），其在整个轴线方向上具有围绕其轴线（O）的均匀内径，并且设置有从内部凹部（11a）凹陷的旁通槽（11a） 所述外管10的内径为6.0mm以上且10.0mm以下，所述多个旁通槽沿所述轴的周向间隔地形成， 垂直于轴的旁通槽的横截面面积是垂直于轴线的外管的内周截面积的0.13％以上且0.24％以下，并且从内侧凹下的旁通槽的深度 圆周面为外管内径的2.7％以上且3.8％以下。 结果，溶液可以顺利地流过旁路槽，并且可以减少残留在旁路槽中的溶液量。

    Two-chamber type combined container syringe
    4.
    发明授权
    Two-chamber type combined container syringe 有权
    双室式组合式集装箱注射器

    公开(公告)号：US09333299B2

    公开(公告)日：2016-05-10

    申请号：US14180353

    申请日：2014-02-13

    Applicant: ARTE CORPORATION

    Inventor： Atsushi Kanazawa ,  Katsuyoshi Tuchida ,  Junichi Komuro ,  Seiji Shimazaki

    IPC: A61M5/19 ,  A61M5/28 ,  A61M5/315 ,  A61M5/31

    CPC classification number: A61M5/19 ,  A61M5/284 ,  A61M5/3137 ,  A61M5/31501 ,  A61M2005/3132

    Abstract: A two-chamber type combined container-syringe includes an outer tube (10) formed in a tubular shape having a uniform inner diameter about an axis (O) thereof throughout the axis direction and provided with a bypass groove (11a) concaved from an inner circumferential surface in a portion in the axis direction, wherein the inner diameter of the outer tube (10) is 6.0 mm or more and 10.0 mm or less, the plurality of bypass grooves are formed in the circumferential direction of the axis at intervals, a cross-sectional area of the bypass groove perpendicular to the axis is 0.13% or more and 0.24% or less of an inner circumferential cross-sectional area of the outer tube perpendicular to the axis, and a depth of the bypass groove concaved from the inner circumferential surface is 2.7% or more and 3.8% or less of the inner diameter of the outer tube. As a result, solution can smoothly flow through the bypass groove, and an amount of solution remaining in the bypass groove can be reduced.

    Abstract translation: 双室型组合容器注射器包括形成为管状的外管（10），其在整个轴线方向上具有围绕其轴线（O）的均匀内径，并且设置有从内部凹部（11a）凹陷的旁通槽（11a） 所述外管10的内径为6.0mm以上且10.0mm以下，所述多个旁通槽沿所述轴的周向间隔地形成， 垂直于轴的旁通槽的横截面面积是垂直于轴线的外管的内周截面积的0.13％以上且0.24％以下，并且从内侧凹下的旁通槽的深度 圆周面为外管内径的2.7％以上且3.8％以下。 结果，溶液可以顺利地流过旁路槽，并且可以减少残留在旁路槽中的溶液量。

    DEVICE FOR ACCOMMODATING A FREEZE-DRIED PHARMACEUTICAL PRODUCT AND METHOD OF MANUFACTURING A SEALED VESSEL ACCOMMODATING A FREEZE-DRIED PHARMACEUTICAL PRODUCT
    5.
    发明申请
    DEVICE FOR ACCOMMODATING A FREEZE-DRIED PHARMACEUTICAL PRODUCT AND METHOD OF MANUFACTURING A SEALED VESSEL ACCOMMODATING A FREEZE-DRIED PHARMACEUTICAL PRODUCT 审中-公开
    用于容纳冷冻干燥药用产品的装置以及制造冷冻干燥药用产品的密封容器的方法

    公开(公告)号：US20150041498A1

    公开(公告)日：2015-02-12

    申请号：US14374971

    申请日：2013-02-11

    Applicant: Arte Corporation

    Inventor： Makoto Kakiuchi ,  Seiji Shimazaki ,  Teruo Matsuda ,  Andreas Schuetz

    IPC: B65D83/00 ,  A61J1/20 ,  B65B63/08 ,  A61J3/00 ,  B65B7/28

    CPC classification number: B65D83/005 ,  A61J1/20 ,  A61J3/00 ,  A61M5/284 ,  A61M2005/3123 ,  B65B3/003 ,  B65B7/2821 ,  B65B63/08 ,  B65B2220/14 ,  B65B2230/02

    Abstract: A device for accommodating a freeze-dried pharmaceutical product (S) for reconstitution, comprising: a vessel (1) having at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), wherein the front plunger (2) is configured to be positioned inside the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), and wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the front plunger (2) is positioned in the exchange state, is characterized in that the sealing means are dimensioned and/or structured in such a way that the front plunger (2), when an underpressure of predefined strength is applied to the outer environment of the vessel (1), is caused to move inside the vessel (1) toward its opening end (3). Furthermore, a method of manufacturing a sealed vessel (1) accommodating a freeze-dried pharmaceutical product (S) is disclosed.

    Abstract translation: 一种用于容纳用于重构的冷冻干燥药物（S）的装置，包括：容器（1），其开口端（3）具有开口边缘（4）和相邻的纵向部分（5），所述容器 横截面，在纵向部分（5）处定位在容器（1）内部的前柱塞（2），其中前柱塞（2）构造成处于密封状态位于容器（1）的内部， 其中前柱塞（2）完全插入容器（1）中，或者处于交换状态，其中前柱塞（2）部分地插入容器（1）中并且部分地突出在开口边缘（4）上， ，并且其中所述前柱塞（2）包括密封装置，所述密封装置构造成当所述前柱塞（2）处于密封状态时将所述容器（1）的内部抵靠在外部密封，并且一个 或更多的连通槽（2i），其构造成将容器（1）的内部和外部放置在通信w中 当前柱塞（2）位于交换状态时彼此相对的特征在于，密封装置的尺寸和/或结构使得当前柱塞（2）施加预定强度的负压时 使容器（1）的外部环境朝向其开口端（3）移动到容器（1）内。 此外，公开了一种制造容纳冷冻干燥药物（S）的密封容器（1）的方法。

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