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公开(公告)号:US20120328613A1
公开(公告)日:2012-12-27
申请号:US13591755
申请日:2012-08-22
IPC分类号: A61K39/395 , C12N15/85 , A61P27/02 , C12P21/04 , C07K16/18 , A61P29/00 , C12N15/13 , C12N5/10
CPC分类号: C07K16/40 , A61K2039/505 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译: 本发明涉及抗因子D抗体,其核酸和氨基酸序列,携带这些抗体的细胞和载体及其生产及其在制备用于治疗与过量或不受控制的疾病和病症的组合物和药物的用途 补体激活。 这些抗体可用于疾病的诊断,预防和治疗。
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公开(公告)号:US08614306B2
公开(公告)日:2013-12-24
申请号:US13591755
申请日:2012-08-22
CPC分类号: C07K16/40 , A61K2039/505 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译: 本发明涉及抗因子D抗体,其核酸和氨基酸序列,携带这些抗体的细胞和载体及其生产及其在制备用于治疗与过量或不受控制的疾病和病症的组合物和药物的用途 补体激活。 这些抗体可用于疾病的诊断,预防和治疗。
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公开(公告)号:US08273352B2
公开(公告)日:2012-09-25
申请号:US12430479
申请日:2009-04-27
CPC分类号: C07K16/40 , A61K2039/505 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译: 本发明涉及抗因子D抗体,其核酸和氨基酸序列,携带这些抗体的细胞和载体及其生产及其在制备用于治疗与过量或不受控制的疾病和病症的组合物和药物的用途 补体激活。 这些抗体可用于疾病的诊断,预防和治疗。
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公开(公告)号:US20090269338A1
公开(公告)日:2009-10-29
申请号:US12430479
申请日:2009-04-27
IPC分类号: A61K39/395 , C07K16/18 , C07K14/00 , C07H21/00 , C12N15/74 , C12N5/06 , C12P21/02 , A61P37/02
CPC分类号: C07K16/40 , A61K2039/505 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译: 本发明涉及抗因子D抗体,其核酸和氨基酸序列,携带这些抗体的细胞和载体及其生产及其在制备用于治疗与过量或不受控制的疾病和病症的组合物和药物的用途 补体激活。 这些抗体可用于疾病的诊断,预防和治疗。
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公开(公告)号:US20060084278A1
公开(公告)日:2006-04-20
申请号:US10549950
申请日:2004-03-19
申请人: Charles Winter , Charles Dezelah
发明人: Charles Winter , Charles Dezelah
IPC分类号: H01L21/31
CPC分类号: C01G3/02 , B82Y30/00 , C01G1/00 , C01G1/02 , C01P2002/72 , C01P2002/88 , C01P2004/04 , C01P2004/64 , C09C1/00 , C09C3/08 , H01L21/288 , H01L21/76838 , H01L21/76877 , Y10S977/762 , Y10S977/773 , Y10S977/775 , Y10S977/776
摘要: The present invention provides a copper oxide-containing composition that includes copper oxide nanoparticles and one or more heteroatom donor ligands bonded to the surface of the nanoparticles, where x and y are numbers having a ratio that is equal to the ratio of the average number of M atoms to the average number of 0 atoms in the nanoparticles. The nanoparticles are stabilized by the one or more heteroatom donor ligands which act as a protective layer that cap the surface of the nanoparticles. The present invention also provides a solution of the copper oxide nanoparticles that may be applied to a substrate and then subsequently reduced to copper metal. Finally, the invention provides a method of preparing the copper oxide nanoparticles.
摘要翻译: 本发明提供一种含氧化铜的组合物,其包含氧化铜纳米颗粒和结合到纳米颗粒表面的一个或多个杂原子供体配体,其中x和y是具有等于平均数 M原子与纳米颗粒中平均数为0个原子。 纳米颗粒被一个或多个杂原子供体配体稳定,其作为覆盖纳米颗粒表面的保护层。 本发明还提供可以施加到基底上然后还原成铜金属的氧化铜纳米颗粒的溶液。 最后,本发明提供一种制备氧化铜纳米颗粒的方法。
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公开(公告)号:US20050277297A1
公开(公告)日:2005-12-15
申请号:US11117443
申请日:2005-04-29
申请人: Charles Winter , Zhengkun Yu , Charles Dezelah
发明人: Charles Winter , Zhengkun Yu , Charles Dezelah
CPC分类号: B22F1/0062 , B22F1/0018 , B22F1/0059 , B22F1/0088 , B22F9/24 , B22F2998/00 , B22F2999/00 , B82Y30/00
摘要: The invention relates to methods of making monodisperse nanocrystals comprising the steps of reducing a copper salt with a reducing agent, providing a passivating agent comprising a nitrogen and/or an oxygen donating moitey and isolating the copper nanocrystals. Moreover, the invention relates to methods for making a copper film comprising the steps of applying a solvent comprising copper nanocrystals onto a substrate and heating the substrate to form a film of continuous bulk copper from said nanocrystals. Finally, the invention also relates to methods for filling a feature on a substrate with copper comprising the steps of applying a solvent comprising copper nanocrystals onto the featured substrate and heating the substrate to fill the feature by forming continuous bulk copper in the feature.
摘要翻译: 本发明涉及制备单分散纳米晶体的方法,包括以下步骤:用还原剂还原铜盐,提供包含氮和/或供氧气味的钝化剂并分离铜纳米晶体。 此外,本发明涉及制备铜膜的方法,包括以下步骤:将包含铜纳米晶体的溶剂施加到基底上,并加热基底以从所述纳米晶体形成连续体铜的膜。 最后,本发明还涉及用铜填充衬底上的特征的方法,包括以下步骤:将铜纳米晶体的溶剂涂覆到特征的衬底上,并通过在特征中形成连续的大块铜来加热衬底以填充该特征。
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7.
公开(公告)号:US20070237762A1
公开(公告)日:2007-10-11
申请号:US11537577
申请日:2006-09-29
申请人: Charles Winter
发明人: Charles Winter
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/4291 , A61K39/39591 , B01D61/142 , B01D61/16 , B01D2311/04 , B01D2311/16 , C07K1/34 , C07K16/065 , C07K2317/21 , B01D2311/10 , B01D2311/246
摘要: The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.
摘要翻译: 本公开提供了一种在高于约30℃的高温下浓缩包括超滤,渗滤和第二超滤序列的蛋白质的方法。本公开还包括制备高度浓缩的抗体组合物的方法,并且高度浓缩 抗体产品。
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8.
公开(公告)号:US20060051347A1
公开(公告)日:2006-03-09
申请号:US11220362
申请日:2005-09-06
申请人: Charles Winter
发明人: Charles Winter
IPC分类号: A61K39/395 , C07K16/44
CPC分类号: C07K16/4291 , A61K39/39591 , B01D61/142 , B01D61/16 , B01D2311/04 , B01D2311/16 , C07K1/34 , C07K16/065 , C07K2317/21 , B01D2311/10 , B01D2311/246
摘要: The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.
摘要翻译: 本公开提供了一种在高于约30℃的高温下浓缩包括超滤,渗滤和第二超滤序列的蛋白质的方法。本公开还包括制备高度浓缩的抗体组合物的方法,并且高度浓缩 抗体产品。
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