公开(公告)号：US09562908B2

公开(公告)日：2017-02-07

申请号：US14460331

申请日：2014-08-14

Applicant: ASAHI KASEI FIBERS CORPORATION

Inventor： Satoru Yoshida ,  Yoshiyuki Shiomi ,  Toshihiko Matsui ,  Masanori Doi ,  Nobuyuki Mimura ,  Takeshi Matsuse

IPC: G01N33/548 ,  G01N33/58 ,  G01N33/558

CPC classification number: G01N33/587 ,  G01N33/548 ,  G01N33/558 ,  G01N33/585 ,  G01N2333/59 ,  G01N2458/00 ,  Y10T428/2982

Abstract: Provided are an immunochromatography kit that is highly sensitive and capable of multicoloration, and organic colored microparticles that are ideal as an element of the immunochromatography kit. Organic colored microparticles having an average grain size between 10 and 1,000 nm and a color intensity between 1.0 and 5.0 are prepared using cellulose as the starting material. When the organic colored microparticles are used as a label in an immunochromatography kit, the immunochromatography kit is of a high sensitivity than conventional technology. The immunochromatography kit is also capable of multicoloration and is useful for rapid diagnosis.

Abstract translation: 提供了高度敏感且能够多色化的免疫色谱试剂盒，以及作为免疫色谱试剂盒的元素的理想的有机彩色微粒。 使用纤维素作为起始原料，制备平均粒径为10〜1000nm，色强度为1.0〜5.0的有机彩色微粒。 当有机彩色微粒用作免疫色谱试剂盒中的标记时，免疫色谱试剂盒比常规技术具有高灵敏度。 免疫色谱试剂盒还能够进行多色化，并且可用于快速诊断。

公开(公告)号：US09341622B2

公开(公告)日：2016-05-17

申请号：US14750970

申请日：2015-06-25

Applicant: Asahi Kasei Fibers Corporation

Inventor： Yoshiyuki Shiomi ,  Toshihiko Matsui ,  Masanori Doi

IPC: G01N33/544 ,  G01N33/548 ,  C08B1/00 ,  C08B1/08 ,  C08B5/14 ,  C08B11/02 ,  C08B11/04 ,  C08B11/08 ,  C08B11/10 ,  C08B11/12 ,  C08B11/145 ,  C08B11/155 ,  C08B11/20 ,  C08B15/00 ,  C08B15/04 ,  C08B15/10 ,  C08B16/00 ,  C08J3/16 ,  C08L1/08 ,  C08L1/26 ,  C08L1/28

CPC classification number: G01N33/548 ,  C08B1/006 ,  C08B1/08 ,  C08B5/14 ,  C08B11/02 ,  C08B11/04 ,  C08B11/08 ,  C08B11/10 ,  C08B11/12 ,  C08B11/145 ,  C08B11/155 ,  C08B11/20 ,  C08B15/005 ,  C08B15/04 ,  C08B15/10 ,  C08B16/00 ,  C08J3/16 ,  C08J2301/28 ,  C08L1/08 ,  C08L1/26 ,  C08L1/28 ,  C08L1/282 ,  C08L1/284 ,  C08L1/286 ,  C08L1/288 ,  G01N2400/26 ,  Y10T428/2982

Abstract: An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle.

公开(公告)号：US20150293082A1

公开(公告)日：2015-10-15

申请号：US14750970

申请日：2015-06-25

Applicant: Asahi Kasei Fibers Corporation

Inventor： Yoshiyuki SHIOMI ,  Toshihiko Matsui ,  Masanori Doi

IPC: G01N33/548

CPC classification number: G01N33/548 ,  C08B1/006 ,  C08B1/08 ,  C08B5/14 ,  C08B11/02 ,  C08B11/04 ,  C08B11/08 ,  C08B11/10 ,  C08B11/12 ,  C08B11/145 ,  C08B11/155 ,  C08B11/20 ,  C08B15/005 ,  C08B15/04 ,  C08B15/10 ,  C08B16/00 ,  C08J3/16 ,  C08J2301/28 ,  C08L1/08 ,  C08L1/26 ,  C08L1/28 ,  C08L1/282 ,  C08L1/284 ,  C08L1/286 ,  C08L1/288 ,  G01N2400/26 ,  Y10T428/2982

Abstract: An object of the present invention is to provide a hydrophilic cellulose derivative fine particle having a small particle size, a dispersion liquid thereof and a dispersion body thereof; and provide a diagnostic reagent composed of the hydrophilic particle, which is excellent in storage stability and does not require excess components, such as an emulsifier or surfactant. The cellulose derivative fine particle of the present invention is a cellulose derivative fine particle comprising a cellulose derivative with a part of hydroxyl groups of cellulose being substituted with a substituent, wherein the average particle diameter is from 9 to 1,000 nm; and the diagnostic reagent of the present invention is a diagnostic reagent obtained by loading a substance differentially interacting with a test object substance on the above-described cellulose derivative fine particle.

Abstract translation: 本发明的目的是提供一种具有小粒径的亲水性纤维素衍生物微粒，其分散液及其分散体; 并且提供由亲水性颗粒组成的诊断试剂，其具有优异的储存稳定性，并且不需要过量的组分如乳化剂或表面活性剂。 本发明的纤维素衍生物微粒是由纤维素衍生物构成的纤维素衍生物微粒，其纤维素的一部分羟基被取代基取代，平均粒径为9〜1000nm， 本发明的诊断试剂是通过将与试验对象物质差异相互作用的物质负载在上述纤维素衍生物微粒上而得到的诊断试剂。