Method for producing polymer particles, and polymer particles
    7.
    发明授权
    Method for producing polymer particles, and polymer particles 有权
    生产聚合物颗粒的方法和聚合物颗粒

    公开(公告)号:US09352298B2

    公开(公告)日:2016-05-31

    申请号:US13994495

    申请日:2011-12-14

    摘要: Provided are polymer particles which can be used at a high flow rate when used as a filler for chromatography, that is, has excellent resistance flow rate appropriate for processing in large quantities, and also has a high binding capacity for target molecules such as proteins when an appropriate ligand is contained in the particles, and a method for producing the polymer particles; specifically, crosslinked polymer particles and a method for producing the crosslinked polymer particles, polysaccharide composite particles and a method for producing the polysaccharide composite particles, a filler for chromatography using the polymer particles, and an adsorbent for antibody purification. Disclosed are: A. a method for producing polysaccharide composite particles, the method including the following steps (1) to (3): (1) a step of preparing a polysaccharide solution, in which two or more kinds of polysaccharides are dissolved in an ionic liquid; (2) a step of preparing a droplet dispersion liquid of the polysaccharide solution, in which liquid droplets of the polysaccharide solution are dispersed in an organic solvent having low compatibility with the ionic liquid; and (3) a coagulation step in which a composite of the polysaccharides are coagulated to obtain the polysaccharide composite particles; and B. a method for producing a crosslinked polymer particle, the method including a step of allowing a polymer dissolved in an ionic liquid, to react with a crosslinking agent while the polymer is subjected to droplet dispersion in an organic solvent having low compatibility with the ionic liquid.

    摘要翻译: 提供当用作色谱填料时可以以高流速使用的聚合物颗粒,即具有适合于大量加工的优异的电阻流速,并且还具有对蛋白质等靶分子的高结合力 粒子中含有适当的配体,以及聚合物粒子的制造方法。 特别是交联聚合物颗粒和交联聚合物颗粒的制备方法,多糖复合颗粒和多糖复合颗粒的制备方法,使用该聚合物颗粒的色谱用填料和用于抗体纯化的吸附剂。 本发明涉及A.一种多糖复合粒子的制造方法,其特征在于,包括以下工序(1)〜(3):(1)制备多糖溶液的工序,其中将2种以上的多糖溶解于 离子液体 (2)将多糖溶液的液滴分散在与离子液体的相容性低的有机溶剂中的多糖溶液的液滴分散液的制备工序; 和(3)将多糖的复合体凝结而得到多糖复合粒子的凝固工序; 和B.一种制备交联聚合物颗粒的方法,该方法包括使溶解在离子液体中的聚合物与交联剂反应的步骤,同时聚合物在与 离子液体。