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    Methods and compositions for diagnosis and prognosis of renal injury and renal failure
    3.
    发明授权
    Methods and compositions for diagnosis and prognosis of renal injury and renal failure 有权

    公开(公告)号：US11262363B2

    公开(公告)日：2022-03-01

    申请号：US15676828

    申请日：2017-08-14

    申请人： ASTUTE MEDICAL, INC.

    发明人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf

    IPC分类号： G01N33/68

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of Hyaluronic acid, Immunoglobulin A, Immunoglobulin G1, Immunoglobulin G2, Insulin-like growth factor-binding protein 7, Alpha-1 antitrypsin, Serum amyloid P component, Metalloproteinase inhibitor 2, Hepatocyte growth factor, Intercellular adhesion molecule 1, Beta-2-glycoprotein 1, Interleukin-1 beta, Neutrophil Elastase, Tumor necrosis factor receptor superfamily member 11B, Interleukin-11, Cathepsin D, C—C motif chemokine 24, C—X—C motif chemokine 6, C—C motif chemokine 13, C—X—C motif chemokines-1, -2, and -3, Matrilysin, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, and Macrophage colony-stimulating factor 1 as diagnostic and prognostic biomarkers in renal injuries.

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    9.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    用于诊断和预防肾损伤和肾功能衰竭的方法和组合

    公开(公告)号：US20150355196A1

    公开(公告)日：2015-12-10

    申请号：US14761591

    申请日：2014-01-16

    申请人： ASTUTE MEDICAL, INC.

    发明人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf

    IPC分类号： G01N33/68 ,  G06F19/24 ,  G06F19/00 ,  G01N33/70

    CPC分类号： G01N33/6893 ,  G01N33/70 ,  G01N2333/4703 ,  G01N2333/4745 ,  G01N2333/65 ,  G01N2333/8146 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  G06F19/00 ,  G06F19/24 ,  G16H50/20 ,  Y02A90/26

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.

    摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用TIMP2和IGFBP7中的一种或多种的测量尿液浓度与测量的血清肌酐和测量的尿液输出中的一种或多种组合，其结果与受试者的肾脏状态相关，以及 可用于患有或患有肾功能损伤，肾功能减退和/或急性肾功能衰竭的受试者的诊断，预后，风险分层，分期，监测，分类和确定进一步的诊断和治疗方案。