公开(公告)号：US20230174465A1

公开(公告)日：2023-06-08

申请号：US17921688

申请日：2021-04-27

申请人： AUTOTAC INC.

发明人： Yong Tae KWON ,  Hyun Tae KIM ,  Jeong Eun NA ,  Yu Jin SEO ,  Chang Hoon JI ,  Ha Rim CHOI ,  Ji Eun LEE ,  Ah Jung HEO

IPC分类号： C07C237/42 ,  C07C235/16

CPC分类号： C07C237/42 ,  C07C235/16

摘要： The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.

公开(公告)号：US20220402873A1

公开(公告)日：2022-12-22

申请号：US17761830

申请日：2020-09-21

申请人： AUTOTAC INC. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Yong Tae KWON ,  Chang Hoon JI ,  Hyun Tae KIM ,  Jeong Eun NA ,  Hee Yeon KIM ,  Min Ju LEE

IPC分类号： C07D213/64 ,  C07D213/69 ,  C07D239/34 ,  C07D213/74 ,  C07D207/335 ,  C07D333/32 ,  C07D307/58 ,  C07D307/52 ,  C07D213/65

摘要： Novel p62 ligand compounds, or a stereoisomer, a solvate, a hydrate, or a prodrug thereof are disclosed. The novel compounds, stereoisomer, solvate, hydrate, or prodrug activates selective autophagy in cells to selectively remove proteins, organelles, and coagulations in the body, and thus can be advantageously used as a pharmaceutical composition for preventing, ameliorating, or treating various proteinopathies. Compositions such as pharmaceutical composition or food compositions containing the novel p62 ligand compounds, stereoisomer, solvate, hydrate, or prodrug thereof as well as uses thereof are disclosed.

公开(公告)号：US20220298113A1

公开(公告)日：2022-09-22

申请号：US17698384

申请日：2022-03-18

申请人： AUTOTAC INC. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Yong Tae KWON ,  Hyun Tae KIM ,  Jeong Eun NA ,  Chang Hoon JI ,  Chang An JUNG

IPC分类号： C07D213/69

摘要： The present specification discloses a novel benzyloxy pyridine derivative compound represented by Chemical Formula 1, a salt thereof, a stereoisomer thereof, a hydrate thereof, or a solvate thereof, and novel uses thereof. The uses comprise the uses in the preparation of a composition for activating autophagy, a composition for activating p62 protein, a composition for inducing oligomerization of p62 protein, or a composition for ameliorating, preventing or treating a disease caused by misfolded protein.

公开(公告)号：US20230174470A1

公开(公告)日：2023-06-08

申请号：US17921687

申请日：2021-04-27

申请人： AUTOTAC INC.

发明人： Yong Tae KWON ,  Hyun Tae KIM ,  Jeong Eun NA ,  Yu Jin SEO ,  Chang Hoon JI ,  Ha Rim CHOI ,  Ji Eun LEE ,  Ah Jung HEO

IPC分类号： C07C311/49 ,  C07D295/135 ,  C07D209/34 ,  C07D209/08 ,  C07D209/42 ,  C07D231/18 ,  C07D209/44 ,  C07D209/30 ,  C07D231/56 ,  C07D211/54 ,  C07D277/36 ,  C07D307/68 ,  C07D207/12 ,  C07D471/04 ,  C07C243/38 ,  C07C243/36 ,  C07C311/39 ,  C07C317/28 ,  C07C317/36

CPC分类号： C07C311/49 ,  C07D295/135 ,  C07D209/34 ,  C07D209/08 ,  C07D209/42 ,  C07D231/18 ,  C07D209/44 ,  C07D209/30 ,  C07D231/56 ,  C07D211/54 ,  C07D277/36 ,  C07D307/68 ,  C07D207/12 ,  C07D471/04 ,  C07C243/38 ,  C07C243/36 ,  C07C311/39 ,  C07C317/28 ,  C07C317/36 ,  C07C2602/08

摘要： The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.