公开(公告)号：US20230174465A1

公开(公告)日：2023-06-08

申请号：US17921688

申请日：2021-04-27

申请人： AUTOTAC INC.

发明人： Yong Tae KWON ,  Hyun Tae KIM ,  Jeong Eun NA ,  Yu Jin SEO ,  Chang Hoon JI ,  Ha Rim CHOI ,  Ji Eun LEE ,  Ah Jung HEO

IPC分类号： C07C237/42 ,  C07C235/16

CPC分类号： C07C237/42 ,  C07C235/16

摘要： The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.

公开(公告)号：US20230174470A1

公开(公告)日：2023-06-08

申请号：US17921687

申请日：2021-04-27

申请人： AUTOTAC INC.

发明人： Yong Tae KWON ,  Hyun Tae KIM ,  Jeong Eun NA ,  Yu Jin SEO ,  Chang Hoon JI ,  Ha Rim CHOI ,  Ji Eun LEE ,  Ah Jung HEO

IPC分类号： C07C311/49 ,  C07D295/135 ,  C07D209/34 ,  C07D209/08 ,  C07D209/42 ,  C07D231/18 ,  C07D209/44 ,  C07D209/30 ,  C07D231/56 ,  C07D211/54 ,  C07D277/36 ,  C07D307/68 ,  C07D207/12 ,  C07D471/04 ,  C07C243/38 ,  C07C243/36 ,  C07C311/39 ,  C07C317/28 ,  C07C317/36

CPC分类号： C07C311/49 ,  C07D295/135 ,  C07D209/34 ,  C07D209/08 ,  C07D209/42 ,  C07D231/18 ,  C07D209/44 ,  C07D209/30 ,  C07D231/56 ,  C07D211/54 ,  C07D277/36 ,  C07D307/68 ,  C07D207/12 ,  C07D471/04 ,  C07C243/38 ,  C07C243/36 ,  C07C311/39 ,  C07C317/28 ,  C07C317/36 ,  C07C2602/08

摘要： The present specification relates to a compound as a UBR box domain ligand. The present specification provides a small molecule compound that binds to the UBR box domain. Further, the present specification provides a composition for inhibiting UBR box domain substrate binding, including a ligand compound that binds to a UBR box domain, a pharmaceutical composition for treating UBR-related disease, and a use thereof.