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公开(公告)号：US20120038913A1
公开(公告)日：2012-02-16
申请号：US13203872
申请日：2010-02-18
CPC分类号： G01N35/028 , B65D85/38 , G01N21/253 , G01N2201/022
摘要： An optical measurement instrument, which is equipped with transportation protection, includes a body structure (201), a mechanical support element(202) for supporting an optical interface, a moveably supported receptable element (211) for receiving a sample plate and located between the mechanical support element and the body structure, and a detachable transportation protection element (212-215) arranged to mechanically restrict movements of the receptable element and the mechanical support element. The transportation protection element is arranged to be pressed between the mechanical support element (202) and the body structure (201). Hence, for the transportation protection, there is no need to use e.g. a bolt that may be more laborious to install and remove than the transportation protection element to be pressed between the mechanical support element (202) and the body structure (201).
摘要翻译： 配有运输保护的光学测量仪器包括主体结构（201），用于支撑光学界面的机械支撑元件（202），可移动支撑的可接收元件（211），用于接收样品板并位于 机械支撑元件和主体结构，以及可拆卸的运输保护元件（212-215），其布置成机械地限制可接收元件和机械支撑元件的移动。 输送保护元件被布置成在机械支撑元件（202）和主体结构（201）之间被按压。 因此，对于运输保护，不需要使用例如 与在机械支撑元件（202）和主体结构（201）之间被按压的运输保护元件相比，可能更麻烦地安装和拆卸的螺栓。
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公开(公告)号：US08896820B2
公开(公告)日：2014-11-25
申请号：US13500333
申请日：2010-10-06
申请人： Markku Ojala , Jyrki Laitinen , Christer Isaksson , Tommi Elo
发明人： Markku Ojala , Jyrki Laitinen , Christer Isaksson , Tommi Elo
CPC分类号： G01N21/6452 , G01N21/0332 , G01N2201/0231 , G05D23/1919
摘要： An optical measurement instrument includes: an excitation light source (120) arranged to produce an excitation beam for at least one of samples to be measured and a detector (132) arranged to detect an emission beam emitted by one of the samples to be measured and to produce a detection signal responsive to the detected emission beam. The optical measurement instrument further includes an arrangement for controlling temperature of the samples to be measured. The arrangement includes: one or more temperature sensors (176) for producing one or more temperature signals responsive to temperature of a measurement chamber (170) of the optical measurement instrument, one or more heating resistors (171-175) arranged to warm the measurement chamber, and a controller (177) arranged to control electrical power supplied to the heating resistors on the basis of the one or more temperature signals.
摘要翻译： 一种光学测量仪器包括：激发光源（120），其布置成产生用于要测量的样品中的至少一个的激发光束;以及检测器（132），其被布置成检测被测样品之一发射的发射光束;以及 以产生响应于检测到的发射光束的检测信号。 光学测量仪器还包括用于控制要测量的样品的温度的装置。 该装置包括：用于产生响应于光学测量仪器的测量室（170）的温度的一个或多个温度信号的一个或多个温度传感器（176），布置成加热测量的一个或多个加热电阻器（171-175） 以及控制器（177），其被配置为基于所述一个或多个温度信号来控制提供给所述加热电阻器的电力。
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公开(公告)号：US20120240692A1
公开(公告)日：2012-09-27
申请号：US13500333
申请日：2010-10-06
申请人： Markku Ojala , Jyrki Laitinen , Christer Isaksson , Tommi Elo
发明人： Markku Ojala , Jyrki Laitinen , Christer Isaksson , Tommi Elo
IPC分类号： G01N21/01
CPC分类号： G01N21/6452 , G01N21/0332 , G01N2201/0231 , G05D23/1919
摘要： An optical measurement instrument includes: an excitation light source (120) arranged to produce an excitation beam for at least one of samples to be measured and a detector (132) arranged to detect an emission beam emitted by one of the samples to be measured and to produce a detection signal responsive to the detected emission beam. The optical measurement instrument further includes an arrangement for controlling temperature of the samples to be measured. The arrangement includes: one or more temperature sensors (176) for producing one or more temperature signals responsive to temperature of a measurement chamber (170) of the optical measurement instrument, one or more heating resistors (171-175) arranged to warm the measurement chamber, and a controller (177) arranged to control electrical power supplied to the heating resistors on the basis of the one or more temperature signals.
摘要翻译： 一种光学测量仪器包括：激发光源（120），其布置成产生用于要测量的样品中的至少一个的激发光束;以及检测器（132），其被布置成检测被测样品之一发射的发射光束;以及 以产生响应于检测到的发射光束的检测信号。 光学测量仪器还包括用于控制要测量的样品的温度的装置。 该装置包括：用于产生响应于光学测量仪器的测量室（170）的温度的一个或多个温度信号的一个或多个温度传感器（176），布置成加热测量的一个或多个加热电阻器（171-175） 以及控制器（177），其被配置为基于所述一个或多个温度信号来控制提供给所述加热电阻器的电力。
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4.发明授权Arrangement and a method for controlling a measurement head of an optical measurement instrument 有权用于控制光学测量仪器的测量头的布置和方法公开(公告)号：US08542349B2
公开(公告)日：2013-09-24
申请号：US13145652
申请日：2010-01-18
IPC分类号： G01B11/16
CPC分类号： G01N35/028 , G01N21/13 , G01N21/6452 , G01N2021/6484 , G01N2035/0424
摘要： An optical measurement instrument includes a measurement head and mechanical support elements arranged to support a sample well plate. The measurement head is moved towards the sample well plate and, after the measurement head has touched the sample well plate, the measurement head is moved backwards away from the sample well plate so as to provide a desired distance between the measurement head and the sample well plate. A sensor device is attached to the mechanical support elements and arranged detect a mechanical effect occurring in the mechanical support elements due to force directed by the measurement head to the sample well plate. Hence, the situation in which the measurement head touches the sample well plate can be detected without a need to provide the measurement head with a force sensor. This is advantageous because the measurement head can be a changeable module of the optical measurement instrument.
摘要翻译： 光学测量仪器包括测量头和布置成支撑样品孔板的机械支撑元件。 测量头朝向样品孔板移动，测量头已经接触样品孔板后，测量头向后移动离开样品孔板，从而在测量头和样品孔之间提供所需的距离 盘子。 传感器装置附接到机械支撑元件并且被布置成检测由于测量头指向样品孔板的力而在机械支撑元件中发生的机械效应。 因此，可以检测测量头接触样品阱板的情况，而不需要向测量头提供力传感器。 这是有利的，因为测量头可以是光学测量仪器的可变模块。
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5.发明申请公开(公告)号：US20120002190A1
公开(公告)日：2012-01-05
申请号：US13145652
申请日：2010-01-18
CPC分类号： G01N35/028 , G01N21/13 , G01N21/6452 , G01N2021/6484 , G01N2035/0424
摘要： An optical measurement instrument includes a measurement head and mechanical support elements arranged to support a sample well plate. The measurement head is moved towards the sample well plate and, after the measurement head has touched the sample well plate, the measurement head is moved backwards away from the sample well plate so as to provide a desired distance between the measurement head and the sample well plate. A sensor device is attached to the mechanical support elements and arranged detect a mechanical effect occurring in the mechanical support elements due to force directed by the measurement head to the sample well plate. Hence, the situation in which the measurement head touches the sample well plate can be detected without a need to provide the measurement head with a force sensor. This is advantageous because the measurement head can be a changeable module of the optical measurement instrument.
摘要翻译： 光学测量仪器包括测量头和布置成支撑样品孔板的机械支撑元件。 测量头朝向样品孔板移动，测量头已经接触样品孔板后，测量头向后移动离开样品孔板，从而在测量头和样品孔之间提供所需的距离 盘子。 传感器装置附接到机械支撑元件并且被布置成检测由于测量头指向样品孔板的力而在机械支撑元件中发生的机械效应。 因此，可以检测测量头接触样品阱板的情况，而不需要向测量头提供力传感器。 这是有利的，因为测量头可以是光学测量仪器的可变模块。
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公开(公告)号：US09006684B2
公开(公告)日：2015-04-14
申请号：US12738843
申请日：2008-10-08
申请人： Jyrki Laitinen , Petri Kivelä
发明人： Jyrki Laitinen , Petri Kivelä
CPC分类号： G01N21/6452 , G01J3/02 , G01J3/0218 , G01J3/0297 , G01J3/10 , G01J3/18 , G01J3/4406 , G01N21/253 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471 , G01N2021/6484 , G01N2201/0627 , G01N2201/0806
摘要： The invention relates to an apparatus and method for optically analyzing samples contained in sample sites of a sample holder by means of fluorescence. The apparatus comprises a first light source comprising a plurality of individual light sources having narrow wavelength bands, means for further limiting wavelength bands of the light emitted by the individual light sources, means for guiding the reduced-wavelength light to the sample sites of the sample holder, and a detector for detecting light from the sample sites. According to the invention said means for further reducing the wavelength bands emitted by the individual light sources comprise a wavelength-tunable single monochromator. The invention allows manufacturing of a microplate reader having the capability for fluorescence measurements at a continuous wavelength range, while maintaining the cost of the device at a reasonable level.
摘要翻译： 本发明涉及一种用于通过荧光光学分析样品保持器的样品位点中包含的样品的装置和方法。 该装置包括：第一光源，其包括具有窄波长带的多个单独的光源;用于进一步限制由各个光源发射的光的波长带的装置;用于将所述还原波长的光引导到所述样品的样品位置的装置 支架和用于检测来自样品位点的光的检测器。 根据本发明，用于进一步减少由各个光源发射的波长带的装置包括波长可调单色器。 本发明允许制造具有在连续波长范围内的荧光测量能力的酶标仪，同时将装置的成本保持在合理的水平。
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公开(公告)号：US20120001089A1
公开(公告)日：2012-01-05
申请号：US13146305
申请日：2010-01-18
申请人： Jyrki Laitinen
发明人： Jyrki Laitinen
CPC分类号： G01N21/13 , G01N21/76 , G01N2021/6421 , G01N2035/00306 , G01N2035/0432
摘要： A body module of an optical measurement instrument includes: a reception device (201) for receiving samples, a first plate (202), a second plate (203) substantially parallel with the first plate and movably supported relative to the first plate in a direction perpendicular to the first and second plates, and walls extending from outer edges of the first plate to outer edges of the second plate. The reception device is located in a measurement chamber constituted by the walls and the first and second plates. At least the second plate includes a fastening interface provided with an aperture. The fastening interface is suitable for an optical module to be mounted to the second plate. The measuring chamber provides protection against undesired stray light from surroundings. The movability of the second plate allows adjustment of a distance between a sample and an optical module mounted to the second plate.
摘要翻译： 光学测量仪器的主体模块包括：用于接收样品的接收装置（201），与第一板基本平行的第一板（202），第二板（203），并相对于第一板沿方向 垂直于第一和第二板，以及从第一板的外边缘延伸到第二板的外边缘的壁。 接收装置位于由壁和第一和第二板构成的测量室中。 至少第二板包括设置有孔的紧固界面。 紧固接口适合于安装到第二板的光学模块。 测量室提供防止周围不期望的杂散光的保护。 第二板的可移动性允许调整样品和安装到第二板的光学模块之间的距离。
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公开(公告)号：US08814427B2
公开(公告)日：2014-08-26
申请号：US13146290
申请日：2009-10-13
申请人： Jyrki Laitinen , Markku Ojala
发明人： Jyrki Laitinen , Markku Ojala
CPC分类号： G01N21/253 , G01N21/6452 , G01N2201/1211
摘要： An optical measurement instrument includes one or more temperature sensors (122) arranged to measure sample well specific temperatures from sample wells (111-117) arranged to store samples (103-109) to be optically measured. A processing device (121) of the optical measurement instrument is arranged to correct, using a pre-determined mathematical rule, measurement results obtained by the optical measurements on the basis of the measured sample well specific temperatures. Hence, the adverse effect caused by temperature differences between different samples on the accuracy of the temperature correction of the measurement results is mitigated.
摘要翻译： 一种光学测量仪器包括一个或多个温度传感器（122），其设置成测量样品阱特定的温度，该样品井被布置成存储待光学测量的样品（103-109）的样品孔（111-117）。 光学测量仪器的处理设备（121）被布置成使用预定的数学规则来校正通过基于测量的样品阱特定温度的光学测量获得的测量结果。 因此，不同样品之间的温度差异对测量结果的温度校正精度的不利影响得到了缓解。
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公开(公告)号：US08742367B2
公开(公告)日：2014-06-03
申请号：US12739144
申请日：2008-10-08
申请人： Jyrki Laitinen , Petri Kivelä
发明人： Jyrki Laitinen , Petri Kivelä
CPC分类号： G01N21/253 , G01J3/0218 , G01J3/10 , G01J3/12 , G01J3/42 , G01J3/44 , G01N21/6408 , G01N21/6452 , G01N2021/6439 , G01N2021/6484 , G01N2021/6491 , G02B6/4298
摘要： An apparatus for optically analyzing samples contained in sample sites of a sample holder, the apparatus has a first light source and at least one second light source, a monochromator having an input to which first light source is optically connected or connectable and an output for monochromatized light, light guiding portion for guiding light originating from the first and from the at least one second light sources to the sample sites, and a detector for detecting light from the sample sites. A light relay having a first input optically connected to the output of the monochromator, at least one second input optically connected or connectable to a second light source such that the light from the second light source by-passes the monochromator, and a first output for guiding light from selected input of the light relay to the sample sites. Based on the apparatus and light relay a versatile sample analyzer can be achieved in a cost-effective manner.
摘要翻译： 一种用于光学分析样品保持器的样品位置中包含的样品的装置，该装置具有第一光源和至少一个第二光源，具有第一光源被光学连接或可连接的输入的单色仪和用于单色化的输出 用于引导来自第一和至少一个第二光源的光源到样品位置的光，光引导部分，以及用于检测来自样品位点的光的检测器。 一种光继电器，具有光学连接到单色仪的输出的第一输入，至少一个第二输入，光学连接或可连接到第二光源，使得来自第二光源的光旁路单色器，以及第一输出， 将光继电器的选定输入的光引导到样品位置。 基于设备和光继电器，可以以成本有效的方式实现通用的样品分析仪。
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公开(公告)号：US08744269B2
公开(公告)日：2014-06-03
申请号：US13146271
申请日：2010-01-18
申请人： Jyrki Laitinen , Antero Yli-Koski , Markku Ojala
发明人： Jyrki Laitinen , Antero Yli-Koski , Markku Ojala
IPC分类号： H04B10/00
CPC分类号： H04J3/0644 , G01N21/6452 , H04L12/40006 , H04L2012/40215
摘要： An optical measurement instrument comprises operational modules (101-107) that are interconnected via a digital communication network (110). Each operational module comprises a transceiver (111-117) connected to the digital communication network and arranged to support a pre-determined digital communication protocol employed in the digital communication network. Those operational modules that include a detector further comprise an analog-to-digital converter (118) for converting a detected signal into a digital form and a digital circuitry (119) for providing digital information based on the detected signal with address data related to a particular operational module to which the digital information is to be delivered via the digital communication network. As information is transferred between operational modules via the digital communication network using the pre-determined digital communication protocol, the operational modules can be tested independently of each other using a test bench system arranged to support the pre-determined digital communication protocol.
摘要翻译： 光学测量仪器包括经由数字通信网络（110）互连的操作模块（101-107）。 每个操作模块包括连接到数字通信网络并被布置成支持在数字通信网络中采用的预定数字通信协议的收发机（111-117）。 包括检测器的那些操作模块还包括用于将检测到的信号转换为数字形式的模拟 - 数字转换器（118）和用于基于检测到的信号提供数字信息的数字电路（119），该数字信号具有与 数字信息将经由数字通信网络传送到的特定操作模块。 由于信息通过使用预定数字通信协议的数字通信网络在操作模块之间传输，所以可以使用布置成支持预定数字通信协议的测试台系统来彼此独立地测试操作模块。
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